Patents by Inventor Kiwamu YAMAGISHI

Kiwamu YAMAGISHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heparosan-glucuronic acid-5-epimerase, and method for producing polysaccharide using same
    Patent number: 9896708
    Abstract: To provide a polypeptide having heparosan-glucuronate 5-epimerase activity, whereby means for producing a polysaccharide in which hexuronic acid residues has been epimerized is provided. Through screening of Achatina fulica cDNA library, a DNA encoding a polypeptide of heparosan-glucuronate 5-epimerase is obtained. The epimerase acts on glucuronic acid residues of N-acetyl heparosan and/or iduronic acid residues of completely desulfated N-acetylated heparin. The polypeptide encoded by the DNA is expressed by insect cells, to thereby yield the polypeptide having heparosan-glucuronate 5-epimerase activity. By bringing the polypeptide into contact with N-acetyl heparosan or completely desulfated N-acetylated heparin, a polysaccharide in which hexuronic acid residues has been epimerized is yielded.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: February 20, 2018
    Assignee: SEIKAGAKU CORPORATION
    Inventors: Hideo Mochizuki, Kiwamu Yamagishi, Kiyoshi Suzuki, Yeong Shik Kim
  • HEPAROSAN-GLUCURONIC ACID-5-EPIMERASE, AND METHOD FOR PRODUCING POLYSACCHARIDE USING SAME
    Publication number: 20160115511
    Abstract: To provide a polypeptide having heparosan-glucuronate 5-epimerase activity, whereby means for producing a polysaccharide in which hexuronic acid residues has been epimerized is provided. Through screening of Achatina fulica cDNA library, a DNA encoding a polypeptide of heparosan-glucuronate 5-epimerase is obtained. The epimerase acts on glucuronic acid residues of N-acetyl heparosan and/or iduronic acid residues of completely desulfated N-acetylated heparin. The polypeptide encoded by the DNA is expressed by insect cells, to thereby yield the polypeptide having heparosan-glucuronate 5-epimerase activity. By bringing the polypeptide into contact with N-acetyl heparosan or completely desulfated N-acetylated heparin, a polysaccharide in which hexuronic acid residues has been epimerized is yielded.
    Type: Application
    Filed: June 12, 2014
    Publication date: April 28, 2016
    Applicant: SEIKAGAKU CORPORATION
    Inventors: Hideo MOCHIZUKI, Kiwamu YAMAGISHI, Kiyoshi SUZUKI, Yeong Shik KIM