Patents by Inventor Kiyoharu Takahashi

Kiyoharu Takahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assaying peptidase enzyme activity
    Patent number: 4675290
    Abstract: A method for assay of enzyme activity which comprises treating an amide compound of the formula ##STR1## with peptidase; treating thus-liberated amine of the formula ##STR2## with an oxidase which consume oxygen and forms pigment by oxidative condensation of said amine with a coupler of the formula ##STR3## and quantitatively measuring the detectable changes. Also disclosed is an assay method which comprises treating an amide compound of the formula ##STR4## or a salt thereof, with peptidase to liberate an aniline derivative of the formula ##STR5## oxidizing said aniline derivative; and quantitatively measuring detectable change.
    Type: Grant
    Filed: March 18, 1985
    Date of Patent: June 23, 1987
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Kunio Matsumoto, Yoshitaka Kagimoto, Tsutomu Hirata, Susumu Watanabe, Akira Ohtsuka, Kiyoharu Takahashi
  • Novel synthetic substrate and assay method using the same
    Patent number: 4588836
    Abstract: A compound of the formula ##STR1## wherein R is L-leucyl or .gamma.-L-glutamyl and X and Y are halogen and are the same or different, or a salt thereof. These compounds are useful as synthetic substrates for assaying peptidase activity.
    Type: Grant
    Filed: August 24, 1983
    Date of Patent: May 13, 1986
    Assignees: Toyo Jozo Kabushiki Kaisha, Kokusan Chemical Works Limited
    Inventors: Kunio Matsumoto, Yoshitaka Kagimoto, Tsutomu Hirata, Susumu Watanabe, Akira Ohtsuka, Kiyoharu Takahashi