Abstract: Novel tetrapeptide acylhydrazides, inclusive of acid addition salts thereof, which have the formula: ##STR1## wherein R.sub.1 is hydrogen or methyl, R.sub.2 is lower alkyl; are useful as analgesics.

Abstract: Novel tetrapeptidesemicarbazide derivatives, inclusive of a pharmacologically acceptable salt thereof, which has the general formula (I): ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen or a D-.alpha.-amino acid side chain; R.sub.3 is hydrogen or lower alkyl; X is oxygen or sulfur, are useful as analgesics.

Abstract: Novel tetrapeptidehydrazide derivatives, inclusive of a pharmacologically acceptable acid addition salt thereof, which has the general formula (I): ##STR1## [wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen or the side chain of a D-.alpha.-amino acid; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, or a saturated or unsaturated and straight or branched lower aliphatic acyl group which may optionally be substituted by hydroxy, amino, lower alkoxy, halogen, oxo, lower alkylthio or lower alkylthiooxide], are useful as analgesics.

Abstract: Isoxazolo[3,4-d]pyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, respectively, are hydrogen, lower alkyl, cycloalkyl, or aryl which may be substituted by halogen, are useful as antiinflammatory-analgesic drugs, and the industrially feasible production thereof is provided.

Abstract: Isoxazolo[3,4-d]pyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 respectively, are hydrogen, lower alkyl, cycloalkyl, or aryl which may be substituted by halogen, are useful as antiinflammatory-analgesic drugs, and the industrially feasible production thereof is provided.

Abstract: Compounds of the formula: ##STR1## WHEREIN R.sup.1 is an aryl group which may be substituted, R.sup.2 is hydrogen or a lower alkyl group having 1 to 4 carbon atoms and n is 1 or 2, or derivatives at the carboxyl function thereof, are useful as medicines such as antipyretics, analgesics and anti-inflammatory agents.

Abstract: A novel indan-1-carboxamide derivative of the formula ##STR1## wherein X represents hydrogen or a halogen; R.sub.1 represents hydrogen, a lower alkyl group which may be substituted with hydroxyl group or represents phenyl group; and R.sub.2 represents a lower alkyl group which may be substituted with hydroxyl, phenyl or an N,N-dilower-alkylamino group, or represents hydroxyl group, an amino group which may be substituted with a mono- or di-lower alkyl group, phenyl group or with a halophenyl group, or represents a phenyl group which may be substituted with a halogen or a mono- or di-lower alkyl group, a lower alkoxyl group or with sulfamoyl group; or R.sub.1 and R.sub.2, together with the adjacent nitrogen atom, form a piperidino group, a morpholino group or a piperazino group which may be substituted with a lower alkyl group on the 4-positioned nitrogen atom, which compounds are useful as medicines, for example, analgesic, anti-inflammatory, anti-pyretic or anti-rheumatic agents.

Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 is an aryl group which may be substituted, R.sup.2 is hydrogen or a lower alkyl group having 1 to 4 carbon atoms and n is 1 or 2, or derivatives at the carboxyl function thereof, are useful as medicines such as antipyretics, analgesics and anti-inflammatory agents.

Abstract: Compounds of the formula: ##SPC1##Wherein R.sup.1 is an aryl group which may be substituted, R.sup.2 is hydrogen or a lower alkyl group having 1 to 4 carbon atoms and n is 1 or 2, or derivatives at the carboxyl function thereof, are useful as medicines such as antipyretics, analgesics and anti-inflammatory agents.