Patents by Inventor Kiyomi Furihata
Kiyomi Furihata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240075407Abstract: In the specification, a method for purifying a compound by column chromatography, and a method for optimizing the symmetry factor and theoretical plate number by allowing the slurry to settle and reducing the sedimentation volume of the slurry. A compound purified by such method is also provided.Type: ApplicationFiled: February 24, 2022Publication date: March 7, 2024Applicant: Nissui CorporationInventors: Kiyomi FURIHATA, Masashi KATAYAMA
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Patent number: 11898120Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.Type: GrantFiled: October 10, 2022Date of Patent: February 13, 2024Assignee: Nissui CorporationInventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi
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Patent number: 11840714Abstract: The present invention provides a method of producing a composition containing docosahexaenoic acid as a constituent fatty acid of glycerides. The method includes hydrolyzing a feedstock oil containing glycerides, the glycerides including docosahexaenoic acid as a constituent fatty acid, by action of a first lipase and a second lipase, to increase the proportion of docosahexaenoic acid in glyceride fractions. The first lipase is at least one lipase selected from the group consisting of a lipase obtained from a microorganism of the genus Thermomyces, a lipase obtained from a microorganism of the genus Pseudomonas, a lipase obtained from a microorganism of the genus Burkholderia, and a lipase obtained from a microorganism of the genus Alcaligenes. The second lipase is a partial glyceride lipase.Type: GrantFiled: September 4, 2019Date of Patent: December 12, 2023Assignee: Nissui CorporationInventors: Yuuji Hirouchi, Isao Yamazaki, Natsuko Watanabe, Kiyomi Furihata
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Publication number: 20230055343Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.Type: ApplicationFiled: October 10, 2022Publication date: February 23, 2023Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Nobushige DOISAKI, Kiyomi FURIHATA, Hideaki YAMAGUCHI
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Patent number: 11499119Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.Type: GrantFiled: January 21, 2021Date of Patent: November 15, 2022Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi
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Publication number: 20220106617Abstract: The present invention provides a method of producing a composition containing docosahexaenoic acid as a constituent fatty acid of glycerides, comprising hydrolyzing a feedstock oil containing glycerides comprising docosahexaenoic acid as a constituent fatty acid by action of a first lipase and a second lipase, thereby increasing the proportion of docosahexaenoic acid in glyceride fractions, wherein the first lipase is at least one lipase selected from the group consisting of a lipase derived from a microorganism of the genus Thermomyces, a lipase derived from a microorganism of the genus Pseudomonas, a lipase derived from a microorganism of the genus Burkholderia, and a lipase derived from a microorganism of the genus Alcaligenes, and wherein the second lipase is a partial glyceride lipase.Type: ApplicationFiled: September 4, 2019Publication date: April 7, 2022Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Yuuji HIROUCHI, Isao YAMAZAKI, Natsuko WATANABE, Kiyomi FURIHATA
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Patent number: 11248190Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.Type: GrantFiled: May 22, 2020Date of Patent: February 15, 2022Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi
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Publication number: 20210324432Abstract: The present invention provides a method of producing a composition containing docosahexaenoic acid as a constituent fatty acid of glycerides, comprising hydrolyzing a feedstock oil containing glycerides comprising docosahexaenoic acid as a constituent fatty acid by action of a Candida cylindracea derived lipase and a partial glyceride lipase, thereby increasing the proportion of docosahexaenoic acid in glyceride fractions, wherein the lipase hydrolysis reaction is performed at a temperature no higher than 30° C. for a period no longer than 15 hours.Type: ApplicationFiled: September 4, 2019Publication date: October 21, 2021Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Yuuji HIROUCHI, Isao YAMAZAKI, Kiyomi FURIHATA, Nobushige DOISAKI
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Publication number: 20210139813Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.Type: ApplicationFiled: January 21, 2021Publication date: May 13, 2021Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Nobushige DOISAKI, Kiyomi FURIHATA, Hideaki YAMAGUCHI
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Patent number: 10927323Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.Type: GrantFiled: May 22, 2020Date of Patent: February 23, 2021Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi
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Publication number: 20200283698Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.Type: ApplicationFiled: May 22, 2020Publication date: September 10, 2020Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi
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Patent number: 10696924Abstract: PROBLEM To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.Type: GrantFiled: May 6, 2019Date of Patent: June 30, 2020Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Nobushige Doisaki, Kiyomi Furihata, Hideaki Yamaguchi
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Publication number: 20200190431Abstract: To provide a composition comprising highly enriched PUFA or its alkyl esters while containing fatty acid esters of 3-MCPD at adequately low concentrations and to provide an efficient method for producing the composition. MEANS FOR SOLVING A composition that contains fatty acids or fatty acid alkyl esters as its major component, the composition containing highly unsaturated fatty acid or alkyl ester thereof, wherein the proportion of the highly unsaturated fatty acid in the constituent fatty acids of the composition is 50 area % or more and wherein the concentration of 3-MCPD as found upon analyzing the composition by American Oil Chemists' Society official method Cd 29b-13 assay A is less than 1.80 ppm.Type: ApplicationFiled: May 6, 2019Publication date: June 18, 2020Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Nobushige DOISAKI, Kiyomi FURIHATA, Hideaki YAMAGUCHI
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Patent number: 9556401Abstract: Alcoholysis of oils and fats containing EPA and DHA is performed by a lipase having substrate specificity for fatty acids having 18 carbons or less and in the presence of a reaction additive such as magnesium oxide; then the glyceride fraction is separated; alcoholysis of the glyceride fraction is performed by a lipase having substrate specificity for fatty acids having 20 carbons or less and in the presence of a reaction additive such as magnesium oxide; and EPA-enriched oil and DHA-enriched oil are simultaneously obtained.Type: GrantFiled: July 29, 2008Date of Patent: January 31, 2017Assignee: NIPPON SUISAN KAISHA, LTD.Inventors: Kiyomi Furihata, Hiroyuki Kawahara, Hideaki Yamaguchi, Hideo Ikemoto, Nobushige Doisaki
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Patent number: 9150817Abstract: The present invention provides a process for concentrated PUFA oil, characterized in that alcoholysis reaction using lipase is carried out in the presence of a small amount of water and at least one compound as an additive selected from magnesium oxide, magnesium hydroxide, calcium oxide and calcium hydroxide, and then separation is conducted to obtain a glyceride fraction.Type: GrantFiled: April 13, 2007Date of Patent: October 6, 2015Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Kiyomi Furihata, Hiroyuki Kawahara, Nobushige Doisaki
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Publication number: 20100190220Abstract: Alcoholysis of oils and fats containing EPA and DHA is performed by a lipase having substrate specificity for fatty acids having 18 carbons or less and in the presence of a reaction additive such as magnesium oxide; then the glyceride fraction is separated; alcoholysis of the glyceride fraction is performed by a lipase having substrate specificity for fatty acids having 20 carbons or less and in the presence of a reaction additive such as magnesium oxide; and EPA-enriched oil and DHA-enriched oil are simultaneously obtained.Type: ApplicationFiled: July 29, 2008Publication date: July 29, 2010Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Kiyomi Furihata, Hiroyuki Kawahara, Hideaki Yamaguchi, Hideo Ikemoto, Nobushige Doisaki
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Publication number: 20090176284Abstract: The present invention provides a process for concentrated PUFA oil, characterized in that alcoholysis reaction using lipase is carried out in the presence of a small amount of water and at least one compound as an additive selected from magnesium oxide, magnesium hydroxide, calcium oxide and calcium hydroxide, and then separation is conducted to obtain a glyceride fraction.Type: ApplicationFiled: April 13, 2007Publication date: July 9, 2009Applicant: Nippon Suisan Kaisha, LTD.Inventors: Kiyomi Furihata, Hiroyuki Kawahara, Nobushige Doisaki
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Patent number: 6905850Abstract: The invention provides a process for producing 2-monoglycerides (2-MG) or triglycerides (TG), particularly triglycerides having polyunsaturated fatty acid (PUFA) residues in the sn-2 positions, at an extremely high purity and a high efficiency. The 2-MG is produced by conducting alcoholysis of a starting TG with a first 1,3-lipase. Then, the TG is produced by introducing fatty acid residues to the 1- and 3-positions of the produced 2-MG by using a second 1,3-lipase. The fatty acid residue in the 2-posiiton is preferably a residue of DHA, EPA or ARA. The “first lipase” refers to one which is selective for the 1- and 3-positions and can act even on a long-chain fatty acid in alcoholysis, while the “second lipase” refers to one which is selective for the 1- and 3-positions and can produce a TG through the reaction of a 2-MG with a fatty acid ester or a free fatty acid.Type: GrantFiled: July 2, 2001Date of Patent: June 14, 2005Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Roxana Irimescu, Kiyomi Furihata, Kazuhiko Hata, Tsuneo Yamane
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Publication number: 20040033571Abstract: The invention provides a process for producing 2-monoglycerides (2-MG) or triglycerides (TG), particularly triglycerides having polyunsaturated fatty acid (PUFA) residues in the sn-2 positions, at an extremely high purity and a high efficiency.Type: ApplicationFiled: August 21, 2003Publication date: February 19, 2004Inventors: Roxan Irimescu, Kiyomi Furihata, Kazuhiko Hata, Tsuneo Yamane
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Patent number: 6117905Abstract: Edible oil containing arachidonic acid obtained from microorganisms belonging to the subgenus Mortierella of the genus Mortierella and being capable of producing arachidonic acid are provided. The oil contain little unsaponifiable matters and, above all, the smallest possible amount of sterol with cyclopropane structure which have not been recognized as food components, and are suitable for the production of foods, in particular, infant formula.Arachidonic acid-containing edible oil originating in microorganisms containing not more than 0.8% by weight, preferably not more than 0.6% by weight of unsaponifiable matters and 20% by weight or more of arachidonic acid. Further, these edible oil contain not more than 0.3% by weight, preferably not more than 0.15% by weight of 24,25-methylenecholest-5-en-3 .beta.-ol. The microorganisms are those belonging to the subgenus Mortierella of the genus Mortierella and being capable of producing arachidonic acid.Type: GrantFiled: June 29, 1999Date of Patent: September 12, 2000Assignees: Suntory Limited, Nippon Suisan Kaisha, Ltd.Inventors: Kenichi Higashiyama, Kengo Akimoto, Sakayu Shimizu, Nobushige Doisaki, Kiyomi Furihata