Abstract: The invention provides a medicament-containing particle wherein an unpleasant taste of the medicament is alleviated, which is obtainable by mixing and granulating the following ingredients: (1) the medicament with an unpleasant taste, (2) methylcellulose and (3) mannitol; and a solid preparation including the particle. The invention can make an unpleasant taste of the medicament alleviated and furthermore when the formulation including the particle is administered, the unpleasant taste can be masked and the formulation has a good dissolvability in gastrointestinal tract.

Abstract: The invention provides a medicament-containing particle wherein an unpleasant taste of the medicament is alleviated, which is obtainable by mixing and granulating the following ingredients: (1) the medicament with an unpleasant taste, (2) methylcellulose and (3) mannitol; and a solid preparation including the particle. The invention can make an unpleasant taste of the medicament alleviated and furthermore when the formulation including the particle is administered, the unpleasant taste can be masked and the formulation has a good dissolvability in gastrointestinal tract.

Abstract: This invention provides small-sized, intrabuccally rapidly disintegrating tablets comprising D-mannitol having an average particle diameter of 31 ?m to 80 ?m, an active ingredient, a disintegrant and stearic acid or a metallic stearate of 0.01% by weight to 0.5% by weight, which have sufficient hardness, do not disintegrate during usual handling, and have a good disintegrability in the oral cavity and a pleasant feeling in a mouth when administered, and further provides a method for producing an intrabuccally rapidly disintegrating tablet containing stearic acid or a metallic stearate in an amount of 0.01% by weight to 0.

Abstract: Method for producing intrabuccally disintegrating tablets, which comprises the following Steps (a), (b) and (c), wherein a medicament is mixed before granulation or tabletting: (a) a step of dissolving at least one saccharide having a high solubility in water and at least one water-soluble binder in water alone or in water and an alcohol; (b) a step of mixing the solution obtained in above Step (a) with at least one excipient, granulating, drying, and tabletting the mixture under a low compression pressure; (c) a step of aging the tablets obtained in Step (b), and intrabuccally disintegrating tablets produced by the above method are provided. The method of the present invention is a simple method for producing intrabuccally disintegrating tablets in large scale without using specific facility, and by which intrabuccally disintegrating tablets showing good disintegrating property in oral cavity as well as having sufficient strength can be obtained.

Abstract: A rapid-releasing oral particle pharmaceutical preparation with its unpleasant taste masked comprising a core and a film layer coating the core, the core at least containing a drug having an unpleasant taste and a water-swelling agent, and the film layer at least containing ethylcellulose and a water-soluble substance, the amount of the drug in the core being at most 40% (based on the final particle preparation and so on), the amount of the water-swelling agent being about 35% to about 70%, the amount of ethylcellulose in the film layer being about 3 to about 11%, and the amount of the water-soluble substance being about 0.1 to about 0.8 times the weight of the ethylcellulose.

Abstract: Novel sugar-coated pharmaceutical composition such as tablets, pills, granules or the like, which contains pullulan in the sugar layer for the purpose of preventing brownish color change of the composition with lapse of time, and a method for preparing the composition.