Patents by Inventor Kiyomi Tsuruda
Kiyomi Tsuruda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9233184Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.Type: GrantFiled: July 8, 2014Date of Patent: January 12, 2016Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kiyomi Tsuruda, Shinji Yamasoto, Kouki Shoho, Masaru Nakanishi
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Patent number: 8932625Abstract: An adhesive patch comprising a substrate and a pressure-sensitive adhesive base, wherein the pressure-sensitive adhesive base comprises a rubbery polymer having double bonds in the main chain and a nonsteroidal anti-inflammatory analgesic and contains a UVA screening agent and/or UVB screening agent as a stabilizer for the rubbery polymer. The adhesive patch is excellent in the stability of the pressure-sensitive adhesive base and in drug infiltration into the skin.Type: GrantFiled: December 24, 2004Date of Patent: January 13, 2015Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Yoshiaki Hashimoto, Yasunori Takada, Miyuki Shinmura, Shigeo Suzuki, Kiyomi Tsuruda, Koichi Ikesue
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Publication number: 20140371693Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.Type: ApplicationFiled: July 8, 2014Publication date: December 18, 2014Inventors: Kiyomi TSURUDA, Shinji YAMASOTO, Kouki SHOHO, Masaru NAKANISHI
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Patent number: 8809615Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.Type: GrantFiled: October 26, 2009Date of Patent: August 19, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Kiyomi Tsuruda, Shinji Yamasoto, Kouki Shoho, Masaru Nakanishi
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Patent number: 8455376Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.Type: GrantFiled: August 1, 2007Date of Patent: June 4, 2013Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Kiyomi Tsuruda, Shinji Yamasoto, Kouki Shoho, Masaru Nakanishi
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Patent number: 8034374Abstract: An adhesive patch containing a non-steroidal anti-inflammatory agent, comprising a support and an adhesive layer laminated on this support, wherein the adhesive layer contains a non-steroidal anti-inflammatory agent having a carboxyl group or its salt, and polyethylene glycol having an average molecular weight of 1000 or more.Type: GrantFiled: March 18, 2004Date of Patent: October 11, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Yasunori Takada, Koji Tanaka, Kiyomi Tsuruda
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Publication number: 20100311700Abstract: A transdermal preparation for external use which contains a photosensitive NSAID and a UV blocker having a high ability to migrate into the skin. Thus, it becomes possible to ensure, in a transdermal preparation for external use containing a NSAID, the inhibition of the onset of light-induced non-immunological or immunological skin symptoms by the above-described component.Type: ApplicationFiled: April 29, 2010Publication date: December 9, 2010Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Kazuhisa Yoshitake, Kenji Atarashi, Tetsuji Kuwahara, Koichi Ikesue, Michinori Sakai, Yoshiaki Hashimoto, Kiyomi Tsuruda
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Publication number: 20100249236Abstract: An adhesive comprising a base with tackiness, an oil and ketoprofen, wherein the adhesive contains no L-menthol, the base is composed at least of a tacky composition comprising an elastomer and a tackifier and/or a tacky polymer containing an unsaturated monomer with a total of 5 or more carbon atoms as the monomer unit, the oil is an oil that is compatible with the tacky composition and the tacky polymer, and the oil content is 150-175 parts by weight with respect to 100 parts by weight as the total of the tacky composition and the tacky polymer.Type: ApplicationFiled: June 7, 2010Publication date: September 30, 2010Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Munehiko HIRANO, Miyuki SHINMURA, Kiyomi TSURUDA
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Publication number: 20100240758Abstract: An external preparation for percutaneous administration which contains a light-sensitive nonsteroidal anti-inflammatory analgesic and a UVA-shielding agent which inhibits the analgesic to cause light toxicity and a light allergy. This external preparation for percutaneous administration, which contains a nonsteroidal anti-inflammatory analgesic, can be prevented, with higher certainty, from causing the hypersensitivity to light attributable to light toxicity and a light allergy.Type: ApplicationFiled: June 3, 2010Publication date: September 23, 2010Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Kazuhisa YOSHITAKE, Kenji ATARASHI, Tetsuji KUWAHARA, Koichi IKESUE, Michinori SAKAI, Yoshiaki HASHIMOTO, Kiyomi TSURUDA
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Publication number: 20100047328Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.Type: ApplicationFiled: October 26, 2009Publication date: February 25, 2010Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kiyomi Tsuruda, Shinji Yamasoto, Kouki Shoho, Masaru Nakanishi
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Publication number: 20090149794Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.Type: ApplicationFiled: August 1, 2007Publication date: June 11, 2009Applicant: HISAMITSU PHARMACEUTICAL CO., INCInventors: Kiyomi Tsuruda, Shinji Yamasoto, Kouki Shoho, Masaru Nakanishi
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Publication number: 20080317689Abstract: A transdermal preparation for external use which contains a photosensitive NSAID and a UV blocker having a high ability to migrate into the skin. Thus, it becomes possible to ensure, in a transdermal preparation for external use containing a NSAID, the inhibition of the onset of light-induced non-immunological or immunological skin symptoms by the above-described component.Type: ApplicationFiled: February 24, 2006Publication date: December 25, 2008Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kazuhisa Yoshitake, Kenji Atarashi, Tetsuji Kuwahara, Koichi Ikesue, Michinori Sakai, Yoshiaki Hashimoto, Kiyomi Tsuruda
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Publication number: 20080292670Abstract: An adhesive comprising a base with tackiness, an oil and ketoprofen, wherein the adhesive contains no L-menthol, the base is composed at least of a tacky composition comprising an elastomer and a tackifier and/or a tacky polymer containing an unsaturated monomer with a total of 5 or more carbon atoms as the monomer unit, the oil is an oil that is compatible with the tacky composition and the tacky polymer, and the oil content is 150-175 parts by weight with respect to 100 parts by weight as the total of the tacky composition and the tacky polymer.Type: ApplicationFiled: July 31, 2008Publication date: November 27, 2008Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Munehiko Hirano, Miyuki Shinmura, Kiyomi Tsuruda
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Publication number: 20070280980Abstract: A percutaneous pharmaceutical preparation for external use containing a nonsteroidal antiinflammatory analgesic. It is effective in inhibiting, with higher certainty, the hypersensitivity to light attributable to the phototoxicity and photoallergy of nonsteroidal antiinflammatory analgesics. It can sufficiently produce the effects of the nonsteroidal antiinflammatory analgesic while preventing the pharmaceutical preparation from being altered with time by the incorporation of a dibenzoylmethane derivative as a UVA absorber. The percutaneous pharmaceutical preparation for external use comprises, as essential ingredients, a nonsteroidal antiinflammatory analgesic, a dibenzoylmethane derivative, and one or more members selected among polyhydric alcohol/fatty acid esters, higher fatty acid esters, and crotamiton.Type: ApplicationFiled: May 13, 2005Publication date: December 6, 2007Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Yoshiaki Hashimoto, Yasunori Takada, Miyuki Shinmura, Kiyomi Tsuruda
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Patent number: 7250546Abstract: This invention provides a patch with less skin stimulation, excellent in long time store stability and heat stability and having favorable tack during use. The patch comprising a styrene-isoprene-styrene block copolymer, polyisobutylene, tackifier, plasticizer and pharmaceutically effective ingredient, in which two or more kinds of polyisobutylene of different average molecular weight are used in combination and the viscosity of the adhesive of the patch is between 1500 and 30,000 poise (at 60° C.) and the tack of the patch is from 5 to 200 g/10 mm.Type: GrantFiled: December 5, 2006Date of Patent: July 31, 2007Assignee: Hisamitsu Pharmaceuticals Co., Inc.Inventors: Kiyomi Tsuruda, Yasuhiro Ikeura
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Publication number: 20070154531Abstract: An adhesive patch comprising a substrate and a pressure-sensitive adhesive base, wherein the pressure-sensitive adhesive base comprises a rubbery polymer having double bonds in the main chain and a nonsteroidal anti-inflammatory analgesic and contains a UVA screening agent and/or UVB screening agent as a stabilizer for the rubbery polymer. The adhesive patch is excellent in the stability of the pressure-sensitive adhesive base and in drug infiltration into the skin.Type: ApplicationFiled: December 24, 2004Publication date: July 5, 2007Inventors: Yoshiaki Hashimoto, Yasunori Takada, Miyuki Shinmura, Shigeo Suzuki, Kiyomi Tsuruda, Koichi Ikesue
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Publication number: 20070148216Abstract: An external preparation for percutaneous administration which contains a light-sensitive nonsteroidal anti-inflammatory analgesic and a UVA-shielding agent which inhibits the analgesic to cause light toxicity and a light allergy. This external preparation for percutaneous administration, which contains a nonsteroidal anti-inflammatory analgesic, can be prevented, with higher certainty, from causing the hypersensitivity to light attributable to light toxicity and a light allergy.Type: ApplicationFiled: September 3, 2004Publication date: June 28, 2007Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Kazuhisa Yoshitake, Kenji Atarashi, Tetsuji Kuwahara, Koichi Ikesue, Michinori Sakai, Yoshiaki Hashimoto, Kiyomi Tsuruda
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Publication number: 20070083139Abstract: This invention provides a patch with less skin stimulation, excellent in long time store stability and heat stability and having favorable tack during use. The patch comprising a styrene-isoprene-styrene block copolymer, polyisobutylene, tackifier, plasticizer and pharmaceutically effective ingredient, in which two or more kinds of polyisobutylene of different average molecular weight are used in combination and the viscosity of the adhesive of the patch is between 1500 and 30,000 poise (at 60° C.) and the tack of the patch is from 5 to 200 g/10 mm.Type: ApplicationFiled: December 5, 2006Publication date: April 12, 2007Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Kiyomi Tsuruda, Yasuhiro Ikeura
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Publication number: 20060263420Abstract: An adhesive comprising a base with tackiness, an oil and ketoprofen, wherein the adhesive contains no L-menthol, the base is composed at least of a tacky composition comprising an elastomer and a tackifier and/or a tacky polymer containing an unsaturated monomer with a total of 5 or more carbon atoms as the monomer unit, the oil is an oil that is compatible with the tacky composition and the tacky polymer, and the oil content is 150-175 parts by weight with respect to 100 parts by weight as the total of the tacky composition and the tacky polymer.Type: ApplicationFiled: March 9, 2006Publication date: November 23, 2006Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Munehiko Hirano, Miyuki Shinmura, Kiyomi Tsuruda
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Publication number: 20060198880Abstract: With the purpose of providing patches which do not cause photodecomposition of drugs even when exposed to the direct rays of the sun and which exhibit satisfactory drug effects and are excellent in physical properties and stability of pharmaceutical preparations, the invention provides a patch comprising a polyester substrate and a pressure-sensitive adhesive layer formed on one surface of the substrate and containing a nonsteroidal anti-inflammatory drug (NSAID) wherein the substrate contains a hydroxyphenylbenzotriazole derivative represented by the general formula (1): wherein R1 and R2 are each independently hydrogen or C1-8 alkyl; and X is halogen atom.Type: ApplicationFiled: May 7, 2004Publication date: September 7, 2006Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Yoshiaki Hashimoto, Yasunori Takada, Kiyomi Tsuruda