Abstract: A preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent dissolution properties, preferable hardness and high drug content uniformity and a manufacturing method thereof. Acetaminophen has a preset particle size and is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed, manufacturing efficiency can be elevated and the cost for manufacturing is also reduced. Thus, an acetaminophen preparation having improved administrability, for example, a reduced size and a manufacturing method thereof are highly useful.

Abstract: A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.

Abstract: The present invention relates to a pre-processing method for the purpose of formulating a drug substance having non-uniform particle sizes by a manufacturing method having excellent manufacture performance. According to the pre-processing method of the present invention, additives including at least a dispersant are blended in a drug substance having a specific particle size distribution and then the resultant mixture is deagglomerated/sized to disperse and make adhere the additives onto the surfaces of the particles of the drug substance, thereby yielding a powder having a specified particle size distribution. In this manner, a pharmaceutical preparation can be manufactured with excellent manufacture performance, manufacture efficiency, and manufacture cost by a direct compression method, a wet continuous granulation system or the like. Therefore, the pre-processing method is very useful.

Abstract: A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.

Abstract: A preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent dissolution properties, preferable hardness and high drug content uniformity and a manufacturing method thereof. Acetaminophen has a preset particle size and is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed, manufacturing efficiency can be elevated and the cost for manufacturing is also reduced. Thus, an acetaminophen preparation having improved administrability, for example, a reduced size and a manufacturing method thereof are highly useful.

Abstract: A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.

Abstract: A method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.

Abstract: A pumping device having an identifying function is provided to allow cost reduction. A return channel and a delivery channel of a pump are connected to a suction tube equipped with a flowmeter, a return tube is connected to the return channel, a solenoid valve is disposed between the suction tube and the delivery channel, and a control unit identifying a fluid by a flow velocity difference of the flowmeter is disposed. The solenoid valve closes the delivery channel when a fluid flows in, the flowmeter measures a flow rate of a fluid sucked through the suction tube, and the fluid is returned to the return tube via the return channel. The control unit opens the solenoid valve to supply the fluid also to the delivery channel when it is identified that a fluid is an intended fluid.

Abstract: A pumping device having an identifying function is provided to allow cost reduction. A return channel and a delivery channel of a pump are connected to a suction tube equipped with a flowmeter, a return tube is connected to the return channel, a solenoid valve is disposed between the suction tube and the delivery channel, and a control unit identifying a fluid by a flow velocity difference of the flowmeter is disposed. The solenoid valve closes the delivery channel when a fluid flows in, the flowmeter measures a flow rate of a fluid sucked through the suction tube, and the fluid is returned to the return tube via the return channel. The control unit opens the solenoid valve to supply the fluid also to the delivery channel when it is identified that a fluid is an intended fluid.

Abstract: A breather device A1 for pressure relief includes a breather pipe 121 serving as a fixing part, and an inner pipe 122 serving as a communication part and is provided by the breather pipe 121 with fixation strength enough for securing the breather device A1 to a liquid tank 101. The inner pipe 122 has a vent hole P formed therein for provide fluid-communication between the inside of the liquid tank 101 and the outside thereof in a manner such that an inner surface forming the vent hole P is made of a resin.

Abstract: A reducing agent container having a multi-function and having a container body thereof is provided with at least a heat exchanger which permits a heating medium using an engine as a heat source thereof to circulate therein for performing the heat exchange with a liquid reducing agent and a strainer which filtrates foreign substances from the liquid reducing agent, the heat exchanger and the strainer being attached to a top board of the container body. Further, a suction pipe capable of sucking the liquid reducing agent from the inside of the container body is connected to the strainer, and a supply port for the liquid reducing agent from which the foreign substances are filtrated is formed in the strainer. Thus, the whole of strainer is not exposed to the outside air, especially, the wind during traveling, and accordingly, the freezing of the urea aqueous solution in the strainer can be suppressed.

Abstract: A liquid reducing agent container structure adapted for an exhaust emission purifying system that is capable of reductively purifying NOx in the exhaust gas using a liquid reducing agent, and provided with a configuration such that a lock (42, 60, 70) is detachably disposed on the outer face of an inlet port (34) disposed on a container body (24A) of a reducing agent container (24), and an engagement portion (36a, 50, 54, 56, 58) with which a locking member (42d, 60d, 70b) of the lock (42, 60, 70) can be engaged is disposed on the side of a cap member (36) which is configured to be screwed on the inlet port (34) to seal the inlet port (34), thereby engaging the locking member (42d, 60d, 70b) with the engagement portion (36a, 50, 54, 56, 58) with a locking operation by the lock (42, 60, 70) to block and prevent a rotation of the cap member (36).

Abstract: A breather device A1 for pressure relief includes a breather pipe 121 serving as a fixing part, and an inner pipe 122 serving as a communication part and is provided by the breather pipe 121 with fixation strength enough for securing the breather device A1 to a liquid tank 101. The inner pipe 122 has a vent hole P formed therein for provide fluid-communication between the inside of the liquid tank 101 and the outside thereof in a manner such that an inner surface forming the vent hole P is made of a resin.

Abstract: A breather device A1 for pressure relief includes a breather pipe 121 serving as a fixing part, and an inner pipe 122 serving as a communication part and is provided by the breather pipe 121 with fixation strength enough for securing the breather device A1 to a liquid tank 101. The inner pipe 122 has a vent hole P formed therein for provide fluid-communication between the inside of the liquid tank 101 and the outside thereof in a manner such that an inner surface forming the vent hole P is made of a resin.

Abstract: A canopy is removably secured to the container body, is respectively fitted with: a base of a water level indicator for detecting a remaining amount of liquid reducing agent; a base of a densitometer for detecting a concentration of a liquid reducing agent; and a heat exchanger which surrounds detection portions respectively suspended from the bases of the water level indicator and the densitometer, and through which is circulated engine coolant, to perform heat exchange with the liquid reducing agent, and a supply port and a return port for the liquid reducing agent are respectively formed in the canopy. The water level indicator, the densitometer, the heat exchanger, and the supply port and the return port for the liquid reducing agent are formed integrally with the canopy, so that the water level indicator and the densitometer can be dismounted together with the canopy at the same time.

Abstract: Mounted on an upper surface of a container main body are a base of a water level indicator detecting a remaining amount of liquid reducing agent, a base of a densitometer detecting concentration of liquid reducing agent, a heat exchanger surrounding detectors of the water level indicator and the densitometer, and circulating engine coolant for heat exchange between liquid reducing agent and engine coolant, and a suction tube for sucking liquid reducing agent from a position adjacent to the bottom of container main body and between water level indicator and densitometer. A box-shaped protector surrounds the water level indicator, densitometer and suction tube which are located in a region adjacent to a lower portion of the heat exchanger. Heat from the heat exchanger is trapped in the protector to generate convection in that region, thereby unfreezing frozen liquid reducing agent around the water level indicator, densitometer and suction tube.

Abstract: Subject To enable an appropriate operation of an exhaust gas purifying apparatus which uses urea or the like as a reducing agent, and further, to enable the stable concentration detection and the stable supply of the reducing agent during the cold months and also to prevent the generation of ammonia series gas during the severe hot months. Means for solving the Subject An exhaust gas purifying apparatus in an engine 1 is for supplying the urea water in a storage tank 20 to a reduction catalyst 3 disposed in an exhaust system. In this exhaust gas purifying apparatus, a concentration detecting device 60 is disposed in the storage tank 20, and the detected concentration of the urea water is adopted as basic information for the supply control of the reducing agent.

Abstract: A canopy is removably secured to the container body, is respectively fitted with: a base of a water level indicator for detecting a remaining amount of liquid reducing agent; a base of a densitometer for detecting a concentration of a liquid reducing agent; and a heat exchanger which surrounds detection portions respectively suspended from the bases of the water level indicator and the densitometer, and through which is circulated engine coolant, to perform heat exchange with the liquid reducing agent, and a supply port and a return port for the liquid reducing agent are respectively formed in the canopy. The water level indicator, the densitometer, the heat exchanger, and the supply port and the return port for the liquid reducing agent are formed integrally with the canopy, so that the water level indicator and the densitometer can be dismounted together with the canopy at the same time.

Abstract: A canopy is removably secured to the container body, is respectively fitted with: a base of a water level indicator for detecting a remaining amount of liquid reducing agent; a base of a densitometer for detecting a concentration of a liquid reducing agent; and a heat exchanger which surrounds detection portions respectively suspended from the bases of the water level indicator and the densitometer, and through which is circulated engine coolant, to perform heat exchange with the liquid reducing agent, and a supply port and a return port for the liquid reducing agent are respectively formed in the canopy. The water level indicator, the densitometer, the heat exchanger, and the supply port and the return port for the liquid reducing agent are formed integrally with the canopy, so that the water level indicator and the densitometer can be dismounted together with the canopy at the same time.

Abstract: In a liquid tank provided with a pressure relief vent hole, a shielding member surrounding the vent hole is disposed. The shielding member forms an isolated chamber communicated with the vent hole. In a portion located to the side of the vent hole, the shielding member allows communication between the isolated chamber and an inner space in the liquid tank excluding the isolated chamber. On the other hand, in a portion located below the vent hole, the shielding member blocks movement of the liquid between the isolated chamber and the inner space.