Patents by Inventor Kiyoshi Ikura

Kiyoshi Ikura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10292934
    Abstract: An object of the present application is to provide an orally-disintegrating tablet having excellent tablet hardness and disintegrability, and including a disintegrative particulate composition. This invention relates to a disintegrative particulate composition comprising the four components consisting of a first disintegrator component of an acid-type carboxymethylcellulose, a second disintegrator component other than the acid-type carboxymethylcellulose, an excipient of a sugar or sugar alcohol, and crystalline cellulose; and to an orally-disintegrating tablet, including the disintegrative particulate composition and a medicinal ingredient.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: May 21, 2019
    Assignees: DAICEL CORPORATION, NICHIRIN CHEMICAL INDUSTRIES, LTD.
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Ishikawa, Tomohito Okabayashi, Naohiro Hashikawa, Tetsuro Morita, Kimiko Ikeda
  • Patent number: 10130584
    Abstract: The purpose of the present invention is to provide a new disintegrative particulate composition having an optimal balance between the tablet hardness and disintegrability that are mutually opposing properties, and disintegrating tablets for pharmaceuticals and various kinds of foods comprising said composition. The present invention relates to a disintegrative particulate composition comprising milled lactose and/or granulated lactose as an excipient, and to a disintegrating tablet for pharmaceuticals or foods, comprising the disintegrative particulate composition, especially the tablet having tablet hardness of from 20 to 200 N, and disintegration time in water of from 1 to 60 sec.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: November 20, 2018
    Assignee: DAICEL CORPORATION
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Tomohito Okabayashi, Yoshihisa Takigawa, Naohiro Hashikawa
  • Publication number: 20180235876
    Abstract: A method is used in the production of a disintegrative particulate composition including three components consisting of a first disintegrator component having sedimentation volume in water of 4.0 cm3/g or more, and a second disintegrator component other than the first disintegrator component and an excipient. The method includes a first wet granulation step using any two of the three components, and a second wet granulation step using the granules obtained in the first wet granulation step and at least the component not used in the first wet granulation step; thus the disintegrative particulate composition is produced. Moreover, an orally disintegrating tablet contains a medicinal ingredient and the disintegrative particulate composition.
    Type: Application
    Filed: April 18, 2018
    Publication date: August 23, 2018
    Inventors: Takahiro HIRAMURA, Kiyoshi IKURA, Sae ITAYA, Tomohito OKABAYASHI, Naohiro HASHIKAWA, Anan SAKAGUCHI
  • Publication number: 20180214377
    Abstract: The purpose of the present invention is to provide a disintegrating tablet having excellent tablet hardness and disintegrability, which is suitable for pharmaceuticals and various kinds of foods such as supplemental foods, nutrition function foods and health foods has been desired as highly convenient forms which can safely be taken by patients who have difficulty in swallowing drugs, elderly people, children, etc., and which can easily be taken without water irrespective of places; and a disintegrative particulate composition comprised in the disintegrating tablet. The present invention relates to a disintegrative particulate composition comprising a disintegrator component and micro-fibrillated cellulose, and a disintegrating tablet for pharmaceuticals or foods, comprising the disintegrative particulate composition, which has excellent tablet hardness and disintegrability.
    Type: Application
    Filed: April 7, 2015
    Publication date: August 2, 2018
    Inventors: Takahiro HIRAMURA, Kiyoshi Ikura, Sae Itaya, Tomohito Okabayashi, Yoshihisa Takigawa, Anan Sakaguchi, Naohiro Hashikawa
  • Patent number: 9974738
    Abstract: A method is used in the production of a disintegrative particulate composition including three components consisting of a first disintegrator component having sedimentation volume in water of 4.0 cm3/g or more, and a second disintegrator component other than the first disintegrator component and an excipient. The method includes a first wet granulation step using any two of the three components, and a second wet granulation step using the granules obtained in the first wet granulation step and at least the component not used in the first wet granulation step; thus the disintegrative particulate composition is produced. Moreover, an orally disintegrating tablet contains a medicinal ingredient and the disintegrative particulate composition.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: May 22, 2018
    Assignee: DAICEL CORPORATION
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Itaya, Tomohito Okabayashi, Naohiro Hashikawa, Anan Sakaguchi
  • Publication number: 20170340568
    Abstract: The purpose of the present invention is to provide a new disintegrative particulate composition having an optimal balance between the tablet hardness and disintegrability that are mutually opposing properties, and disintegrating tablets for pharmaceuticals and various kinds of foods comprising said composition. The present invention relates to a disintegrative particulate composition comprising milled lactose and/or granulated lactose as an excipient, and to a disintegrating tablet for pharmaceuticals or foods, comprising the disintegrative particulate composition, especially the tablet having tablet hardness of from 20 to 200 N, and disintegration time in water of from 1 to 60 sec.
    Type: Application
    Filed: October 8, 2015
    Publication date: November 30, 2017
    Inventors: Takahiro HIRAMURA, Kiyoshi IKURA, Tomohito OKABAYASHI, Yoshihisa TAKIGAWA, Naohiro HASHIKAWA
  • Publication number: 20160250144
    Abstract: An object of the present invention is to provide a disintegrative particulate composition that can be used for an orally disintegrating tablet having both excellent tablet hardness and disintegrability. This invention relates to a method for the production of a disintegrative particulate composition including three components consisting of a first disintegrator component having sedimentation volume in water of 4.0 cm3/g or more, a second disintegrator component other than the first disintegrator component and an excipient, which comprises a first wet granulation step using any two of the three components and a second wet granulation step using the granules obtained in the first wet granulation step and at least the remaining one component not used in the first wet granulation step; the disintegrative particulate composition thus produced; and an orally disintegrating tablet comprising a medicinal ingredient and the disintegrative particulate composition.
    Type: Application
    Filed: September 24, 2014
    Publication date: September 1, 2016
    Inventors: Takahiro HIRAMURA, Kiyoshi IKURA, Sae ITAYA, Tomohito OKABAYASHI, Nohiro HASHIKAWA, Anan SAKAGUCHI
  • Publication number: 20160213619
    Abstract: An object of the present invention is to provide an orally disintegrating tablet having both an excellent tablet hardness and disintegrability even when the content of a medicinal ingredient is high. This invention relates to an orally disintegrating tablet comprising a medicinal ingredient having distribution coefficient (log P) in a range of from ?6.0 to 10.0 and a disintegrative particulate composition produced by granulation consisting of at least two stages, especially to said orally disintegrating tablet having tablet hardness of from 30 to 100 N, and disintegration time in water of from 10 to 30 sec.
    Type: Application
    Filed: September 24, 2014
    Publication date: July 28, 2016
    Inventors: Takahiro HIRAMURA, Kiyoshi IKURA, Sae ITAYA, Tomohito OKABAYASHI, Anan SAKAGUCHI, Tetsuro MORITA, Kimiko IKEDA
  • Publication number: 20150238424
    Abstract: An object of the present application is to provide an orally-disintegrating tablet having excellent tablet hardness and disintegrability, and including a disintegrative particulate composition. This invention relates to a disintegrative particulate composition comprising the four components consisting of a first disintegrator component of an acid-type carboxymethylcellulose, a second disintegrator component other than the acid-type carboxymethylcellulose, an excipient of a sugar or sugar alcohol, and crystalline cellulose; and to an orally-disintegrating tablet, including the disintegrative particulate composition and a medicinal ingredient.
    Type: Application
    Filed: September 13, 2013
    Publication date: August 27, 2015
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Ishikawa, Tomohito Okabayashi, Naohiro Hashikawa, Tetsuro Morita, Kimiko Ikeda
  • Publication number: 20150174075
    Abstract: An object of the present application is to provide an orally-disintegrating tablet having excellent tablet hardness and disintegrability and a disintegrative particulate composition by which the orally-disintegrating tablet can be obtained with a relatively low tablet compression force and which can provide excellent moldability, as well as a method of producing the same, etc.
    Type: Application
    Filed: March 27, 2013
    Publication date: June 25, 2015
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Itaya, Tomohito Okabayashi, Naohiro Hashikawa, Tetsuro Morita, Kimiko Ikeda, Haruka Wakayma
  • Patent number: 8993790
    Abstract: Provide is an oxetane-ring containing (meth) acrylic ester compound which can give, through polymerization, a cured article being highly flexible or thermally stable. The oxetane-ring-containing (meth) acrylic ester compound is represented by formula (1) below, in which R1 represents a hydrogen atom or an alkyl group; R2 represent a hydrogen atom or a methyl group; and “A” represent either a linear alkylene group represented by following formula (a1) or a branched-chain alkylene group represented by following formula (a2).
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: March 31, 2015
    Assignee: Daicel Corporation
    Inventors: Tamaki Son, Kiyoshi Ikura
  • Publication number: 20150045452
    Abstract: The present application provides an orally-disintegrating tablet having excellent tablet hardness and disintegrability. The present application further provides a method of producing a disintegrative particulate composition including three components consisting of a first disintegrator component of an acid-type carboxymethylcellulose, a second disintegrator component and an excipient. The method includes a first wet granulation step using any two of the three components, and a second wet granulation step using granules obtained in the first wet granulation step and the remaining one component of the three components not used in the first wet granulation step. The production method may further includes a crystalline cellulose as a fourth component or a third step of mixing a crystalline cellulose into granules obtained in the second wet granulation step. Disintegrative particulate compositions obtained by these methods are also disclosed.
    Type: Application
    Filed: March 27, 2013
    Publication date: February 12, 2015
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Itaya, Tomohito Okabayashi, Naohiro Hashikawa, Tetsuro Morita, Kimko Ikeda, Haruka Wakayama
  • Publication number: 20120232295
    Abstract: Provided is a novel oxetane-ring-containing (meth)acrylic ester compound which can give, through polymerization, a cured article being highly flexible or thermally stable. The oxetane-ring-containing (meth)acrylic ester compound is represented by formula (1) below, in which R1 represents a hydrogen atom or an alkyl group; R2 represents a hydrogen atom or a methyl group; and “A” represents either a linear alkylene group represented by following formula (a1) or a branched-chain alkylene group represented by following formula (a2).
    Type: Application
    Filed: November 5, 2010
    Publication date: September 13, 2012
    Inventors: Tamaki Son, Kiyoshi Ikura
  • Patent number: 7109350
    Abstract: A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a): wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R2a is typically a hydrocarbon group having at least one oxo group and optionally having other substituent, with an optically active amine of Formula (2): wherein R3 is an unsubstituted or substituted aryl group; R4 is an unsubstituted or substituted lower alkyl group; and C1 is an asymmetric carbon atom, in the presence of an organic acid to thereby yield a corresponding optically active imine, hydrogenating the imine in the presence of a catalyst to yield a corresponding amine, subjecting the amine or its salt to hydrogenolysis in the presence of a catalyst, and reducing the hydrogenolyzed product with a reducing agent.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: September 19, 2006
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Hiroki Tanaka, Li Rui Pan, Kiyoshi Ikura
  • Patent number: 6906197
    Abstract: A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a) wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R2a is typically a hydrocarbon group having at least one oxo group and optionally having other substituent, with an optically active amine of Formula (2): wherein R3 is an unsubstituted or substituted aryl group; R4 is an unsubstituted or substituted lower alkyl group; and C1 is an asymmetric carbon atom, in the presence of an organic acid to thereby yield a corresponding optically active imine, hydrogenating the imine in the presence of a catalyst to yield a corresponding amine, subjecting the amine or its salt to hydrogenolysis in the presence of a catalyst, and reducing the hydrogenolyzed product with a reducing agent.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: June 14, 2005
    Assignee: Daicel Chemical Industries, Ltd
    Inventors: Hiroki Tanaka, Li Rui Pan, Kiyoshi Ikura
  • Publication number: 20040235928
    Abstract: A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a): 1
    Type: Application
    Filed: June 29, 2004
    Publication date: November 25, 2004
    Applicant: Daicel Chemical Industries, Ltd.
    Inventors: Hiroki Tanaka, Li Rui Pan, Kiyoshi Ikura
  • Patent number: 6710210
    Abstract: Novel N-substituted-aminomethyl cyclopropyl ketone derivatives are represented by following Formula (1): wherein R1, R2 and R3 are each a hydrogen atom or an aliphatic hydrocarbon group; and R4 and R5 are each a hydrogen atom or an arylmethyl group which may have a substituent, where at least one hydrogen atom or aryl group as a substituent is combined with a carbon atom in the methyl moiety of the arylmethyl group, and at least one of R4 and R5 is an arylmethyl group which may have a substituent. These compounds are useful for the preparation of aminomethyl cyclopropyl ketone derivatives and 2-amino-1-cyclopropylethanol derivatives or salts thereof.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: March 23, 2004
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Hiroki Tanaka, Li Rui Pan, Kiyoshi Ikura
  • Patent number: 6613935
    Abstract: A process includes allowing a &bgr;-ketoester derivative represented by following Formula (1): wherein R1 is a hydrogen atom or a hydrocarbon group; and R2 is a hydrocarbon group, to react with 1,2-dichloroethane and there by produces a 1-acyl-1-cyclopropanecarboxylate derivative represented by following Formula (2): wherein R1 and R2 have the same meanings as defined above.
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: September 2, 2003
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Hiroki Tanaka, Li Rui Pan, Kiyoshi Ikura
  • Publication number: 20030139628
    Abstract: A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a) 1
    Type: Application
    Filed: December 6, 2002
    Publication date: July 24, 2003
    Inventors: Hiroki Tanaka, Li Rui Pan, Kiyoshi Ikura
  • Publication number: 20030065212
    Abstract: A process includes allowing a &bgr;-ketoester derivative represented by following Formula (1): 1
    Type: Application
    Filed: September 12, 2002
    Publication date: April 3, 2003
    Inventors: Hiroki Tanaka, Li Rui Pan, Kiyoshi Ikura