Patents by Inventor Kiyoshi Iwaoka

Kiyoshi Iwaoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals
    Patent number: 7309710
    Abstract: Obtaining the crystal of 4,6-dimethyl-4?-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide having excellent activity of inhibiting Ca2+ release-activated Ca2+ channel and suppressing IL-2 production to find that the compound includes the presence of two types of polymorphic crystals and that any of the crystals is preferable as a raw material for producing pharmaceutical compositions.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: December 18, 2007
    Assignee: Astellas Pharma Inc.
    Inventors: Hirokazu Kubota, Kiyoshi Iwaoka, Sou Yamaguchi, Masaki Yokota
  • Novel crystals
    Publication number: 20060069130
    Abstract: Obtaining the crystal of 4,6-dimethyl-4?-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide having excellent activity of inhibiting Ca2+ release-activated Ca2+ channel and suppressing IL-2 production to find that the compound includes the presence of two types of polymorphic crystals and that any of the crystals is preferable as a raw material for producing pharmaceutical compositions.
    Type: Application
    Filed: August 26, 2003
    Publication date: March 30, 2006
    Applicant: YAMANOUCHI PHARMACEUTICAL CO., LTD.
    Inventors: Hirokazu Kubota, Kiyoshi Iwaoka, Sou Yamaguchi, Masaki Yokota
  • 5-HT.sub.3 receptor agonist, novel thiazole derivative and intermediate thereof
    Patent number: 5834499
    Abstract: A 5-HT.sub.3 receptor against containing a thiazole derivative as the effective ingredient is provided and is represented by the Formula (I): ##STR1## wherein the A ring is substituted or unsubstituted and represents a benzene or a heterocyclic ring with one or two heteroatoms;one of L.sub.1 or L.sub.
    Type: Grant
    Filed: August 26, 1996
    Date of Patent: November 10, 1998
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Kiyoshi Iwaoka, Hideki Anan, Naoki Imanishi, Kenichi Kazuta, Hiroyuki Koshio, Takeshi Suzuki, Hirotsune Itahana, Hiroyuki Ito, Keiji Miyata, Mitsuaki Ohta
  • Condensed thiazole derivative, production process thereof and pharmaceutical composition thereof
    Patent number: 5565479
    Abstract: Condensed thiazole derivatives useful as 5-HT.sub.3 receptor agonists are provided and can be represented by the following formula (I) or a pharmaceutically acceptable salt thereof, a process for the production thereof and a pharmaceutical composition thereof: ##STR1## wherein R, A, L.sub.1, L.sub.2, L, and R.sup.1 -R.sup.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: October 15, 1996
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Kiyoshi Iwaoka, Hiroyuki Koshio, Hiroyuki Ito, Keiji Miyata, Mitsuaki Ohta
  • Urea derivatives and salts thereof
    Patent number: 5420348
    Abstract: Urea derivatives of the general formula (I) ##STR1## and salts thereof, pharmaceutical compositions containing the same, and methods for producing the same are-disclosed.The urea derivatives of the general formula (I) and salts thereof are novel compounds having the acyl-CoA cholesterol acyltransferase (ACAT) inhibiting activity.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: May 30, 1995
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Noriki Ito, Koyo Matsuda, Kiyoshi Iwaoka, Yuichi Iizumi
  • Urea derivatives and salts thereof in method for inhibiting the ACAT enzyme
    Patent number: 5258405
    Abstract: Urea derivatives of the general formula (I) ##STR1## and salts thereof, pharmaceutical compositions containing the same, and methods for producing the same are disclosed.The urea derivatives of the general formula (I) and salts thereof are novel compounds having the acyl-CoA cholesterol acyltransferase (ACAT) inhibiting activity.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: November 2, 1993
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Noriki Ito, Koyo Matsuda, Kiyoshi Iwaoka