Abstract: This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein the dashed lines represent optional double bonds; C1, C2, C3 and C4 are carbon atom; R1 is C1-4 alkyl; R2 is H, amino, etc.; R3 is H, halo-CH2—, C2-8 alkyl or Q1-, wherein said C2-8 alkyl is optionally substituted with up to 3 substituents selected from halo, C1-3 alkyl, R4(R5)N, etc.; R4 is H, C1-7 alkyl, etc.; R5 is H, C1-7alkyl, etc.; R6 and R7 are independently selected from H and C1-4 alkyl; R8 is aryl or heteroaryl; Q1 is a 4-12 membered monocyclic or bicyclic aromatic, partially saturated or fully saturated ring optionally containing up to 4 heteroatoms selected from O, N and S, and is optionally substituted with halo, C1-4 alkyl, etc.; Y5, Y6, Y7 and Y8 are hydrogen; Y1, Y2, Y3 and Y4 are independently selected from hydrogen, halo, etc.

Abstract: A silent piano is a composite keyboard musical instrument fabricated on the basis of an acoustic piano, and a pianist plays a tune by piano tones or electronic tones; when the pianist selects the electronic tones, a hammer stopper enters the trajectories of hammers, and a tandem regulating button mechanism changes damping columns onto the trajectories of jacks in such a manner that the jack is brought into contact with the damping column concurrently with a regulating button; since the damping columns are closer to the jack than the regulating buttons, the jack turns at a larger angular velocity so that the hammer is not pinched between the jack and the hammer stopper; the damping columns are moved onto a virtual plane where the regulating buttons are so that the jacks are commonly used between the silent piano and the standard acoustic piano.

Abstract: A grand piano has a keyboard placed on a key bed, and the keyboard is covered with a fall board after completion of practice on the keyboard, wherein a recess is formed in the fall board in such a manner as to offer a clearance to fingers on the black keys so that, even if the pianist straightens his or her fingers on the land portion before moving them to other keys, the nails are never hit against the inner surface of the fall board.

Abstract: This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is (C1-C4)alkyl optionally substituted with halo, amino or an alkyl amino; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.

Abstract: This invention provides compounds of the formula (I) and (II): 1

Abstract: This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, —NR2R3 or heterocycle; Q is selected from the following: (a) an optionally substituted phenyl, (b) an optionally substituted 6-membered monocyclic aromatic group containing one, two, three or four nitrogen atom(s), (c) an optionally substituted 5-membered monocyclic aromatic group containing one heteroatom selected from O, S and N and optionally containing one, two or three nitrogen atom(s) in addition to said heteroatom, (d) an optionally substituted C3-7 cycloalkyl and (e) an optionally substituted benzo-fuzed heterocycle; R1 is hydrogen, C1-4 alkyl or halo; R2 and R3 are independently hydrogen, OH, C1-4 alkoxy, C1-4 alkyl or C1-4 alkyl substituted with halo, OH, C1-4 alkoxy or CN; X is independently selected from H, halo, C1-4 alkyl, halo-substituted C1-4 alkyl, OH, C1-4 alkoxy, halo-substituted C1-4 alkoxy, C1-4 alkylthio, NO2, NH2, di-(C1-4 al

Abstract: This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is NH2; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.

Abstract: This invention relates to a compound of the formula: 1

Abstract: This invention provides a compound of the formula (I): 1

Abstract: An exhaust emission purifier includes a catalyst unit disposed in an exhaust pipe of an engine. Electrodes (reaction adjustment unit) are provided on a honeycomb carrier of the catalyst unit in a layered form in order to apply an electric field to the vicinity of the catalyst surface to thereby adjust the catalytic reaction. An ECU serves as a status detection unit to detect factors which affect the exhaust gas purifying performance of the catalyst unit (i.e., operating conditions), and serves as a control unit which controls the electric field applied by the electrodes, on the basis of the detected operating conditions.

Abstract: The present plasma type exhaust gas cleaning apparatus comprises a dielectric (5) arranged between a discharge electrode (7) and a ground electrode (8). The dielectric has a plurality of independent cavities (6) formed therein. The exhaust gas from combustion equipment (1) flows through the interiors of the plurality of independent cavities (6). Thus, in the plasma type exhaust gas cleaning apparatus, the discharge electrode (7) and the ground electrode (8) are securely partitioned by the cavities (6). When a voltage from a high voltage generator (9) is applied to between the discharge electrode (7) and the ground electrode (8), plasma resulting from corona discharges occurs in each individual cavity (6) without arising directly across the discharge electrode (7) and the ground electrode (8). The exhaust gas is thereby cleaned up.

Abstract: A grand piano has a keyboard placed on a key bed, and the keyboard is covered with a fall board after completion of practice on the keyboard, wherein a recess is formed in the fall board in such a manner as to offer a clearance to fingers on the black keys so that, even if the pianist straightens his or her fingers on the land portion before moving them to other keys, the nails are never hit against the inner surface of the fall board.

Abstract: A silent piano is a composite keyboard musical instrument fabricated on the basis of an acoustic piano, and a pianist plays a tune by piano tones or electronic tones; when the pianist selects the electronic tones, a hammer stopper enters the trajectories of hammers, and a tandem regulating button mechanism changes damping columns onto the trajectories of jacks in such a manner that the jack is brought into contact with the damping column concurrently with a regulating button; since the damping columns are closer to the jack than the regulating buttons, the jack turns at a larger angular velocity so that the hammer is not pinched between the jack and the hammer stopper; the damping columns are moved onto a virtual plane where the regulating buttons are so that the jacks are commonly used between the silent piano and the standard acoustic piano.

Abstract: An automatic player piano is an acoustic piano equipped with a data acquisition system and a playback system, and the data acquisition system monitors the hammers with hammer sensors for producing a set of music data codes representative of a performance on the keyboard, wherein the hammer sensor has a detectable range over the trajectory of the associated hammer so that the data acquisition system obtains pieces of music data accurately representative of the trajectory of hammer to be required for a faithful reproduction of the original performance.

Abstract: A keyboard musical instrument has keys equal to a multiple of five assigned to the fingers of a trainee, an electric tutor and an electronic sound generating system, and the electric tutor gives the trainee guide in practicing the fingering along a passage, wherein the electronic sound generating system generates the tones when the trainee satisfies predetermined conditions for the training so as to correctly guide him in the practice.

Abstract: A keyboard musical instrument that is equipped with an electric tutor for guiding a trainee in practicing manipulation of black and white piano keys, whereby the electric tutor reads pieces of musical data information representative of the black and white keys to be depressed and a timing to depress each of the black or white keys for guiding the trainee in the fingering. More specifically, while the trainee is practicing a piece of music, the electric tutor automatically sinks the designated black or white keys as an advanced notice to the trainee so that the trainee can prepare to depress the keys at the appropriate timing, and whereby the electric tutor sinks the same keys again for an inductive action at the time when such keys are to be appropriately depressed.

Abstract: An exhaust emission purifier includes a catalyst unit disposed in an exhaust pipe of an engine. Electrodes (reaction adjustment unit) are provided on a honeycomb carrier of the catalyst unit in a layered form in order to apply an electric field to the vicinity of the catalyst surface to thereby adjust the catalytic reaction. An ECU serves as a status detection unit to detect factors which affect the exhaust gas purifying performance of the catalyst unit (i.e., operating conditions), and serves as a control unit which controls the electric field applied by the electrodes, on the basis of the detected operating conditions.

Abstract: This invention provides a compound of the following formula: and the pharmaceutically acceptable salts thereof, wherein L is oxygen or sulfur; Y is a direct bond or C1-4 alkylidene; Q is C1-6 alkyl, C3-7 cycloalkyl, phenyl, naphthyl, heteroaryl or the like; R1 is hydrogen, C1-6 alkyl or the like; R2 is hydrogen, C1-4 alkyl, C(O)R5 wherein R5 is C1-22 alkyl or C2-22 alkenyl, halosubstituted C1-8 alkyl, halosubstituted C2-8alkenyl, —Y—C3-7 cycloalkyl, —Y—C3-7 cycloalkenyl, phenyl, naphthyl, heteroaryl or the like; X is halo, C1-4 alkyl, hydroxy, C1-4 alkoxy or the like; and n is 0, 1, 2 or 3, with the proviso that a group of formula —Y—Q is not methyl or ethyl when X is hydrogen; L is oxygen; R1 is hydrogen; and R2 is acetyl. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.

Abstract: The present plasma type exhaust gas cleaning apparatus comprises a dielectric (5) arranged between a discharge electrode (7) and a ground electrode (8). The dielectric has a plurality of independent cavities (6) formed therein. The exhaust gas from combustion equipment (1) flows through the interiors of the plurality of independent cavities (6). Thus, in the plasma type exhaust gas cleaning apparatus, the discharge electrode (7) and the ground electrode (8) are securely partitioned by the cavities (6). When a voltage from a high voltage generator (9) is applied to between the discharge electrode (7) and the ground electrode (8), plasma resulting from corona discharges occurs in each individual cavity (6) without arising directly across the discharge electrode (7) and the ground electrode (8). The exhaust gas is thereby cleaned up.

Abstract: A music performance assisting system analyzes a set of music data codes representative of a series of notes and rests forming a tune, and selectively assigns the notes to the five fingers of each hand of a player, wherein the music performance assisting system temporarily assigns notes of each of plural note groups to the fingers in accordance with rules of a fingering for obtaining candidates of a finger pattern, and, thereafter, evaluates the candidates on the basis of rules of a desirable fingering so as to determine the optimum use of fingers so as to decrease the data base and speed up the data processing.