Patents by Inventor Kiyoshi Kita
Kiyoshi Kita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230190690Abstract: The present invention provides a therapeutic and/or preventive agent for coronavirus disease 2019 (COVID-19) comprising 5-aminolevulinic acid (ALA) or its derivative or a salt thereof and provides a method for treating and/or preventing coronavirus disease 2019 (COVID-19) using the therapeutic and/or preventive agent.Type: ApplicationFiled: April 22, 2021Publication date: June 22, 2023Applicants: NEOPHARMA JAPAN CO., LTD., NAGASAKI UNIVERSITYInventors: Kiyoshi KITA, Kouichi MORITA, Jiro YASUDA, Yasuteru SAKURAI, Satofumi KAWATA, Tohru TANAKA, Motoyasu TOMIOKA, Kiyotaka FUJINE
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Patent number: 11306317Abstract: The problem to be solved by the present invention is to provide a method of producing isoprenoids including ascofuranone, ilicicolin A, and ascochlorin and derivatives thereof in a high yield as compared to the conventional art, which method enables industrial-scale production of isoprenoids. The problem can be solved by a method of producing isoprenoids such as ascofuranone, ilicicolin A, and ascochlorin, including using a transformant obtained by transformation with biosynthetic genes for ascofuranone, ilicicolin A, or ascochlorin or a knockout organism for these genes to obtain isoprenoids such as ascofuranone, ilicicolin A, and ascochlorin.Type: GrantFiled: May 11, 2018Date of Patent: April 19, 2022Assignees: NAGASAKI UNIVERSITY, KIKKOMAN CORPORATIONInventors: Yasuko Araki, Yasutomo Shinohara, Kiyoshi Kita
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Patent number: 10702507Abstract: The present invention is intended to provide a novel parasiticide, antiprotozoal or other endoparasite control agents which are effective for controlling animal endoparasites that have been impossible to control by conventional ones. Provided is an endoparasite control agent comprising, as an active ingredient, a carboxamide derivative represented by the general formula (I): or a salt thereof.Type: GrantFiled: October 15, 2018Date of Patent: July 7, 2020Assignees: THE UNIVERSITY OF TOKYO, NIHON NOHYAKU CO., LTD.Inventors: Kiyoshi Kita, Akiyuki Suwa, Masatsugu Oda
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Publication number: 20200063143Abstract: The problem to be solved by the present invention is to provide a method of producing isoprenoids including ascofuranone, ilicicolin A, and ascochlorin and derivatives thereof in a high yield as compared to the conventional art, which method enables industrial-scale production of isoprenoids. The problem can be solved by a method of producing isoprenoids such as ascofuranone, ilicicolin A, and ascochlorin, including using a transformant obtained by transformation with biosynthetic genes for ascofuranone, ilicicolin A, or ascochlorin or a knockout organism for these genes to obtain isoprenoids such as ascofuranone, ilicicolin A, and ascochlorin.Type: ApplicationFiled: May 11, 2018Publication date: February 27, 2020Applicants: KIKKOMAN CORPORATION, NAGASAKI UNIVERSITYInventors: Yasuko ARAKI, Yasutomo SHINOHARA, Kiyoshi KITA
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Publication number: 20190046511Abstract: The present invention is intended to provide a novel parasiticide, antiprotozoal or other endoparasite control agents which are effective for controlling animal endoparasites that have been impossible to control by conventional ones. Provided is an endoparasite control agent comprising, as an active ingredient, a carboxamide derivative represented by the general formula (I): or a salt thereof.Type: ApplicationFiled: October 15, 2018Publication date: February 14, 2019Applicants: THE UNIVERSITY OF TOKYO, NIHON NOHYAKU CO., LTD.Inventors: Kiyoshi KITA, Akiyuki SUWA, Masatsugu ODA
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Patent number: 10017490Abstract: An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): or a salt thereof as an active ingredient.Type: GrantFiled: September 15, 2016Date of Patent: July 10, 2018Assignees: The University of Tokyo, Nihon Nohyaku Co., Ltd.Inventors: Kiyoshi Kita, Akiyuki Suwa, Masatsugu Oda, Koji Tanaka
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Patent number: 9737504Abstract: The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents —CHO, and R4 represents —CH2—CH?C(CH3)—R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.Type: GrantFiled: June 14, 2016Date of Patent: August 22, 2017Assignee: INSTITUTE OF MITOCHONDRIA SCIENCE, INC.Inventors: Kiyoshi Kita, Ken Daniel Inaoka, Hiroyuki Saimoto, Masaichi Yamamoto
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Publication number: 20170037029Abstract: An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): (wherein Het represents a 5- or 6-membered heterocyclic group), or a salt thereof as an active ingredient.Type: ApplicationFiled: October 20, 2016Publication date: February 9, 2017Inventors: Kiyoshi Kita, Akiyuki Suwa, Masatsugu Oda, Koji Tanaka
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Patent number: 9562034Abstract: An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): (wherein Het represents a 5- or 6-membered heterocyclic group), or a salt thereof as an active ingredient.Type: GrantFiled: August 29, 2013Date of Patent: February 7, 2017Assignees: The University of Tokyo, Nihon Nohyaku Co., Ltd.Inventors: Kiyoshi Kita, Akiyuki Suwa, Masatsugu Oda, Koji Tanaka
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Patent number: 9550749Abstract: An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): or a salt thereof as an active ingredient.Type: GrantFiled: August 29, 2013Date of Patent: January 24, 2017Assignees: The University of Tokyo, Nihon Nohyaku Co., Ltd.Inventors: Kiyoshi Kita, Akiyuki Suwa, Masatsugu Oda, Koji Tanaka
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Publication number: 20170014395Abstract: An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): or a salt thereof as an active ingredient.Type: ApplicationFiled: September 15, 2016Publication date: January 19, 2017Inventors: Kiyoshi Kita, Akiyuki Suwa, Masatsugu Oda, Koji Tanaka
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Publication number: 20160367532Abstract: The present invention is intended to provide a novel parasiticide, antiprotozoal or other endoparasite control agents which are effective for controlling animal endoparasites that have been impossible to control by conventional ones. Provided is an endoparasite control agent comprising, as an active ingredient, a carboxamide derivative represented by the general formula (I): or a salt thereof.Type: ApplicationFiled: March 4, 2015Publication date: December 22, 2016Applicants: THE UNIVERSITY OF TOKYO, NIHON NOHYAKU CO., LTD.Inventors: Kiyoshi KITA, Akiyuki SUWA, Masatsugu ODA
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Publication number: 20160362393Abstract: The present invention is intended to provide a novel parasiticide, antiprotozoal or other endoparasite control agents which are effective for controlling animal endoparasites that have been impossible to control by conventional ones. Provided is an endoparasite control agent comprising, as an active ingredient, a heterocyclic carboxamide derivative represented by the general formula (I): or a salt thereof.Type: ApplicationFiled: March 4, 2015Publication date: December 15, 2016Applicants: THE UNIVERSITY OF TOKYO, NIHON NOHYAKU CO., LTD.Inventors: Kiyoshi KITA, Akiyuki SUWA, Masatsugu ODA
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Publication number: 20160296494Abstract: The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents —CHO, and R4 represents —CH2—CH?C(CH3)—R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.Type: ApplicationFiled: June 14, 2016Publication date: October 13, 2016Inventors: Kiyoshi KITA, Ken Daniel INAOKA, Hiroyuki SAIMOTO, Masaichi YAMAMOTO
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Patent number: 9463175Abstract: Provided is an antimalarial drug which is useful for prevention and treatment of infectious diseases caused by malaria parasites. A preventive and/or therapeutic agent for malaria, which contains, as an active ingredient, 5-aminolevulinic acid (ALA), a derivative thereof, or a pharmacologically acceptable salt thereof, is used.Type: GrantFiled: June 22, 2015Date of Patent: October 11, 2016Assignees: SBI Pharmaceuticals Co., Ltd., The University of TokyoInventors: Tohru Tanaka, Satofumi Kawata, Takeo Kohda, Motowo Nakajima, Kiyoshi Kita
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Patent number: 9447042Abstract: Provided are an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): or a salt thereof as an active ingredient, and a method for controlling endoparasites, comprising orally or parenterally administering the endoparasite control agent.Type: GrantFiled: March 1, 2012Date of Patent: September 20, 2016Assignees: THE UNIVERSITY OF TOKYO, NIHON NOHYAKU CO., LTD.Inventors: Kiyoshi Kita, Akiyuki Suwa
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Publication number: 20160263081Abstract: Provided is a new antiparasitic agent for medical use, veterinary use, agrochemical use, and use in fish, said antiparasitic agent having an effect on both helminths and protozoa. The antiparasitic agent uses at least one siccanin produced by Helminthosproium siccans which is a filamentous fungus, a synthetic siccanin, or a modified derivative thereof.Type: ApplicationFiled: October 17, 2014Publication date: September 15, 2016Applicant: NAI Inc.Inventors: Kiyoshi KITA, Ken Daniel INAOKA, Masaichi YAMAMOTO
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Patent number: 9440913Abstract: Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) (wherein, X represents a hydrogen atom or a halogen atom; R1 represents a hydrogen atom; R2 represents a hydrogen atom or a C1-7 alkyl group; R3 represents —CHO, —C(?O)R5, —COOR5 (wherein R5 represents a C1-7 alkyl group), —CH2OH or —COOH; and R4 represents a C1-16 alkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), a C2-16 alkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a C2-16 alkynyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s)), an optical isomer thereof, and a pharmaceutically acceptable salt is used.Type: GrantFiled: November 1, 2011Date of Patent: September 13, 2016Assignee: NAI INC.Inventors: Hiroyuki Saimoto, Kiyoshi Kita, Yoshisada Yabu, Masaichi Yamamoto
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Publication number: 20150283102Abstract: Provided is an antimalarial drug which is useful for prevention and treatment of infectious diseases caused by malaria parasites. A preventive and/or therapeutic agent for malaria, which contains, as an active ingredient, 5-aminolevulinic acid (ALA), a derivative thereof, or a pharmacologically acceptable salt thereof, is used.Type: ApplicationFiled: June 22, 2015Publication date: October 8, 2015Inventors: Tohru Tanaka, Satofumi Kawata, Takeo Kohda, Motowo Nakajima, Kiyoshi Kita
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Publication number: 20150266853Abstract: An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): (wherein Het represents a 5- or 6-membered heterocyclic group), or a salt thereof as an active ingredient.Type: ApplicationFiled: August 29, 2013Publication date: September 24, 2015Inventors: Kiyoshi Kita, Akiyuki Suwa, Masatsugu Oda, Koji Tanaka