Abstract: A purine-derived substance is produced by culturing a bacterium belonging to the genus Bacillus which is able to produce purine-derived substance and has been modified so that enzymatic activity of fructose bisphosphatase is decreased, and collecting the purine-derived substance from the medium or cells.

Abstract: By reacting inosinic acid (IMP) with a bacterium which has been modified so that IMP dehydrogenase activity and 5?-guanylic acid (GMP) synthetase activity are enhanced, GMP is produced.

Abstract: A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in the medium or the bacterial cells, and can be collected from the medium or the bacterial cells.

Abstract: A purine-derived substance is produced by culturing a bacterium belonging to the genus Bacillus which has an ability to produce a purine-derived substance and has been modified so that enzymatic activity of transaldolase is decreased in a medium to cause accumulation of a purine-derived substance in the medium or cells, and collecting the purine-derived substance from the medium or cells.

Abstract: The present invention relates to a method for detecting an ageing or a disease accompanied with a vascular disorder such as age-related macular degeneration, comprising measuring one or more of polypeptides comprising any of amino acid sequences shown in SEQ ID NOS: 1 to 21, mutants thereof, or fragments thereof in a biological sample from a subject, and also to a composition or kit for diagnosing an ageing or a disease accompanied with a vascular disorder such as age-related macular degeneration.

Abstract: The present invention relates to a method for detecting a disease accompanied with neuropathy such as glaucoma, comprising measuring and/or detecting one or more of polypeptides shown in SEQ ID NOS: 1 to 15, mutants thereof, or fragments thereof in a biological sample from a subject, and also to a composition or kit for diagnosis of a disease accompanied with neuropathy such as glaucoma.

Abstract: By reacting inosinic acid (IMP) with a bacterium which has been modified so that IMP dehydrogenase activity and 5?-guanylic acid (GMP) synthetase activity are enhanced, GMP is produced.

Abstract: A purine-derived substance is produced by culturing a bacterium belonging to the genus Bacillus which has an ability to produce a purine-derived substance and has been modified so that enzymatic activity of transaldolase is decreased in a medium to cause accumulation of a purine-derived substance in the medium or cells, and collecting the purine-derived substance from the medium or cells.

Abstract: A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in the medium or the bacterial cells, and can be collected from the medium or the bacterial cells.

Abstract: Dosimeters 140 are housed in dosimeter housing pockets 130 of a dosimeter fitting wear including: wear main bodies 120, 150 which cover measuring positions on at least subject bodies 100, 102, and 110, and can be detachably fitted on the subject bodies, and the dosimeter housing pockets 130 provided at positions that come to the measuring positions when the wear main bodies are fitted on the subject bodies, and then the wear main bodies are fitted on the subject bodies. Thereby, a number of dosimeters can be easily fitted on or detached from the surfaces of subject bodies without hindering medical activities, and set positions of the dosimeters can be easily reproduced.

Abstract: A purine-derived substance is produced by culturing a bacterium belonging to the genus Bacillus which is able to produce purine-derived substance and has been modified so that enzymatic activity of fructose bisphosphatase is decreased, and collecting the purine-derived substance from the medium or cells.

Abstract: The invention provides a method of relieving or avoiding a steroid-induced increase in intraocular pressure caused by the administration of asteroid. The steroid-induced increase in intraocular pressure can be relieved or avoided by incorporating a steroid in fine particles.

Abstract: Dosimeters 140 are housed in dosimeter housing pockets 130 of a dosimeter fitting wear including: wear main bodies 120, 150 which cover measuring positions on at least subject bodies 100, 102, and 110, and can be detachably fitted on the subject bodies, and the dosimeter housing pockets 130 provided at positions that come to the measuring positions when the wear main bodies are fitted on the subject bodies, and then the wear main bodies are fitted on the subject bodies. Thereby, a number of dosimeters can be easily fitted on or detached from the surfaces of subject bodies without hindering medical activities, and set positions of the dosimeters can be easily reproduced.

Abstract: A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in the medium or the bacterial cells, and can be collected from the medium or the bacterial cells.

Abstract: The present invention provides a drug delivery system that is a sustained drug delivery system targeting a tissue in the posterior segment of the eye accompanied by low degree of tissue invasiveness without need of frequent administration, and enables selective delivery of a drug to the posterior segment of the eye, thereby reducing influences due to transfer of the drug to the anterior segment. By administrating fine particles containing a drug to sub-Tenon, a drug delivery system enabling a drug to be selectively delivered to tissues in the posterior segment and an effective concentration to be kept can be constructed.

Abstract: A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in the medium or the bacterial cells, and can be collected from the medium or the bacterial cells.

Abstract: Strains showing favorable growth in a medium containing 6-ethoxypurine are selected from a population of Bacillus bacteria, and a strain showing high inosine-producing ability is selected from the obtained strains to obtain a Bacillus bacterium having improved inosine-producing ability.

Abstract: A method for preventing or treating drug dependence comprising administering to a human in need thereof a pharmaceutically effective amount of a 1,4-(diphenylalkyl)piperazine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, wherein R1 is lower alkoxy; R2 is lower alkoxy; A is lower alkylene and B is lower alkylene;

Abstract: A method for preventing or treating drug dependence comprising administering to a human in need thereof a pharmaceutically effective amount of a 1,4-(diphenylalkyl)piperazine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, wherein R1 is lower alkoxy; R2 is lower alkoxy; A is lower alkylene and B is lower alkylene; 1

Abstract: This invention relates to novel compounds of the formula ?I!, ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents a lower alkoxy group; A and B are the same or different and each represents a lower alkylene group.The compounds of this invention have affinities for sigma receptors and are useful for therapeutic agents for cerebral neural function disorders such as dementia, depression, schizophrenia and anxiety neurosis, diseases accompanying abnormal immune response and cryptorrhea, digestive ulcer, etc.