Patents by Inventor Kiyoshi Mizukoshi

Kiyoshi Mizukoshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ergoline derivatives and acid addition salts thereof
    Patent number: 4713457
    Abstract: Novel ergoline derivatives and acid addition salts thereof are disclosed. These ergoline derivatives possess excellent anti-hypertensive activity, vasodilating activity, anti-ulcer activity, gastric secretion inhibitory activity, brain metabolism improving activity, anti-depressive activity and dopamine-like activity, and, therefore, are useful for prevention and treatment of various diseases such as hypertension, a wide variety of vein disorders, peptic ulcer, brain absormality, depression, Parkinson's disease, high prolactin blood disease, etc.
    Type: Grant
    Filed: February 21, 1986
    Date of Patent: December 15, 1987
    Assignee: Maruko Seiyaku Co., Ltd.
    Inventors: Sachio Ohno, Yuko Ebihara, Kiyoshi Mizukoshi, Kenji Ichihara, Takao Ban, Mitsuaki Nagasaka
  • Certain pyridyloxy-or-thio-phenyl propenoic acid derivatives
    Patent number: 4496735
    Abstract: Novel pyridine compounds and the pharmaceutically acceptable salts thereof having a specific inhibitory activity on thromboxane A.sub.2 biosynthesis in mammals useful for prevention and treatment of various disorders caused by thromboxane A.sub.2, for example, thrombosis, cardiac infarction, diabetic vascular complications, asthma, etc. are disclosed.
    Type: Grant
    Filed: February 24, 1983
    Date of Patent: January 29, 1985
    Assignee: Maruko Seiyaku Co., Ltd.
    Inventors: Sachio Ohno, Kiyoshi Mizukoshi, Osamu Komatsu, Mitsuaki Nagasaka, Yoshiki Nakamura
  • 1,4-Dihydropyridine compounds
    Patent number: 4446325
    Abstract: 1,4-Dihydropyridine compounds having excellent coronary and vertebral vasodilation, blood pressure depression and anti-hypertensive activities are disclosed. These compounds are low toxic and stable to light, and are very useful for pharmaceutical agents.
    Type: Grant
    Filed: October 19, 1982
    Date of Patent: May 1, 1984
    Assignee: Maruko Seiyaku Co., Ltd.
    Inventors: Sachio Ohno, Kiyoshi Mizukoshi, Osamu Komatsu, Kenzi Ichihara, Takashi Morishima
  • Thiopyranopyrimidine compounds and acid addition salts thereof
    Patent number: 4435566
    Abstract: Novel thiopyranopyrimidine compounds and the pharmaceutically acceptable acid addition salts thereof having excellent hypoglycemic activity, platelet aggregation inhibitory activity, antihistamine activity and anti-allergy activity useful for prevention and treatment of various disorders caused by diabetes, allergy and the like are disclosed.
    Type: Grant
    Filed: February 25, 1983
    Date of Patent: March 6, 1984
    Assignee: Maruko Seiyaku Co., Ltd.
    Inventors: Sachio Ohno, Kiyoshi Mizukoshi, Osamu Komatsu, Hajimu Yamamoto, Yasuo Kunou
  • 1,5-Benzothiazepine compounds
    Patent number: 4264497
    Abstract: Cis or trans-1,5-benzothiazepine compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and R.sub.2 represents a hydrogen atom, an alkyl group or a hydroxyalkyl group and the pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof which exhibit anticholinergic activity and are useful as anti-ulcer, gastric secretion inhibiting and antispasmodic agents in mammals, and a process for preparing the same.
    Type: Grant
    Filed: February 14, 1979
    Date of Patent: April 28, 1981
    Assignee: Maruko Seiyaku Co., Ltd.
    Inventors: Sachio Ohno, Kihachiro Izumi, Kiyoshi Mizukoshi, Kazuo Kato, Hajimu Yamamoto, Mitsuaki Nagasaka, Yoshiki Nakamura, Mikio Hori