Patents by Inventor Kiyoshi Oguma

Kiyoshi Oguma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4507232
    Abstract: This invention is directed to novel peptide derivatives. Said peptide derivatives are useful as a substrate for the activity assay of enzymes of the group EC 3. 4. 22, for example, cathepsin L, cathepsin B and cathepsin H. Said peptide derivatives which contain L-methionine radical are prepared according to the methods conventional in peptide chemistry. As typical examples are mentioned D-leucyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate, .beta.-alanyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate and succinyl-L-tyrosyl-L-methionine-p-nitroanilide.
    Type: Grant
    Filed: December 16, 1983
    Date of Patent: March 26, 1985
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Masaharu Tamai, Takashi Adachi, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura, Nobuhiko Katunuma
  • Patent number: 4474800
    Abstract: An epoxysuccinyl amino acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, benzyl or cycloalkyl having 5 to 6 carbon atoms, R.sup.2 is alkyl having 3 to 4 carbon atoms, R.sup.3 is hydrogen, benzyloxycarbonyl, acetyl or benzoyl, and n is an integer of 2 to 7. The subject compounds exhibit inhibitory activity towards thiol protease, especially, calcium-activated neutral thiol protease which exists in excess in muscle tissues of mammals afflicted with muscular dystrophy.
    Type: Grant
    Filed: May 13, 1980
    Date of Patent: October 2, 1984
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Masaharu Tamai, Shigeo Morimoto, Takashi Adachi, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura
  • Patent number: 4418075
    Abstract: An epoxysuccinyl amino acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen or alkali metal, R.sup.2 is isobutyl, R.sup.3 is hydrogen or benzyloxycarbonyl, and n is an integer of 5 to 7. The subject compounds exhibit inhibitory activity towards thiol protease, especially, calcium-activated neutral thiol protease which exists in excess in muscle tissues of mammals afflicted with muscular dystrophy.
    Type: Grant
    Filed: November 10, 1981
    Date of Patent: November 29, 1983
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Masaharu Tamai, Shigeo Morimoto, Takashi Adachi, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura
  • Patent number: 4387238
    Abstract: The epoxysuccinamic acid compounds of the present invention are prepared by reaction of monoesters of epoxysuccinic acid or monoesters of epoxysuccinic acid chloride with amino compounds. These epoxysuccinamic acid compounds have excellent anti-inflammatory activity, thiol protease inhibitory activity, muscular dystrophy inhibitory activity and anti-hypertensive activity without acceleration of vascular permeability.
    Type: Grant
    Filed: May 14, 1981
    Date of Patent: June 7, 1983
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Masami Goi, Kazuya Kameo, Jiro Sawada, Kazunori Hanada, Masaharu Tamai, Kiyoshi Oguma
  • Patent number: 4382889
    Abstract: An epoxysuccinic acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkyl having 1-2 carbon atoms, cycloalkyl having 5-6 carbon atoms or benzyl, R.sup.2 is alkyl having 3-4 carbon atoms or benzyl, R.sup.3 is hydrogen or methyl, and R.sup.4 is alkyl having 1-10 carbon atoms, phenyl, benzyl, phenethyl, cycloalkyl having 3-6 carbon atoms or a group of the formula ##STR2## wherein R.sup.5 is hydrogen, alkyl having 1-4 carbon atoms or said alkyl substituted with hydroxy, methylmercapto, phenyl, hydroxyphenyl, indolyl, an optionally protected carboxy, an optionally protected amino or an optionally protected guanidino, and R.sup.6 is hydroxy, alkalimetaloxy, alkoxy having 1-2 carbon atoms, benzyloxy, amino or dimethylamino, or R.sup.3 and R.sup.4 taken together with the nitrogen atom to which they are attached form a 5-6 membered heterocyclic ring, or said heterocyclic ring substituted with a protected carboxy.
    Type: Grant
    Filed: December 30, 1981
    Date of Patent: May 10, 1983
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Masahuru Tamai, Takashi Adachi, Shigeo Morimoto, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura
  • Patent number: 4333879
    Abstract: An epoxysuccinic acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkyl having 1-2 carbon atoms, cycloalkyl having 5-6 carbon atoms or benzyl, R.sup.2 is alkyl having 3-4 carbon atoms or benzyl, R.sup.3 is hydrogen or methyl, and R.sup.4 is alkyl having 1-10 carbon atoms, phenyl, benzyl, phenethyl or cycloalkyl having 3-6 carbon atoms or R.sup.3 and R.sup.4 taken together with the nitrogen atom to which they are attached form a 5-6 membered heterocyclic ring, or said heterocyclic ring substituted with a protected carboxy.
    Type: Grant
    Filed: January 3, 1980
    Date of Patent: June 8, 1982
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Masaharu Tamai, Takashi Adachi, Shigeo Morimoto, Kiyoshi Oguma, Kazunori Hanada, Sadafumi Omura