Patents by Inventor Kiyotoshi Mori
Kiyotoshi Mori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230123801Abstract: A liquid chromatograph includes a liquid feeding portion, a sample injection portion, a separation column, a first temperature adjustment device which raises temperature of the separation column to a first temperature, a detector, a second temperature adjustment device which is provided upstream of the separation column and adjusts temperature of a mobile phase to a second temperature lower than the first temperature, and a control device which controls at least one of the liquid feeding portion and the second temperature adjustment device. The control device controls at least one of the liquid feeding portion and the second temperature adjustment device such that the mobile phase adjusted to the second temperature is fed to the separation column before a next sample is injected after separation of sample components by the separation column ends.Type: ApplicationFiled: September 30, 2022Publication date: April 20, 2023Inventors: Norimasa MINAMOTO, Yusuke HOSEN, Kiyotoshi MORI, Masahito ITO
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Publication number: 20220135691Abstract: A therapeutic or prophylactic agent for radiation damage associated with radiation exposure, comprising an eosinophil-removing agent as an active ingredient and the like are provided as a technique for efficiently treating or preventing radiation damage associated with radiation exposure. According to the therapeutic or prophylactic agent comprising an eosinophil-removing agent according to the present invention, by suppressing migration and/or infiltration into target tissue and/or proliferation in the tissue of eosinophils and/or inhibiting the activity or function of the eosinophils, pathological conditions such as inflammatory responses and fibrosis of tissue can be suppressed to effectively treat or prevent radiation damage. Moreover, effective radiation therapy can be performed by suppressing radiation damage.Type: ApplicationFiled: November 18, 2021Publication date: May 5, 2022Applicants: Kyowa Kirin Co., Ltd., The University of TokyoInventors: Kazuki OKADA, Kiyotoshi Mori, Satoshi Uematsu, Naoki Takemura
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Patent number: 11208491Abstract: A therapeutic or prophylactic agent for radiation damage associated with radiation exposure, comprising an eosinophil-removing agent as an active ingredient and the like are provided as a technique for efficiently treating or preventing radiation damage associated with radiation exposure. According to the therapeutic or prophylactic agent comprising an eosinophil-removing agent according to the present invention, by suppressing migration and/or infiltration into target tissue and/or proliferation in the tissue of eosinophils and/or inhibiting the activity or function of the eosinophils, pathological conditions such as inflammatory responses and fibrosis of tissue can be suppressed to effectively treat or prevent radiation damage. Moreover, effective radiation therapy can be performed by suppressing radiation damage.Type: GrantFiled: January 22, 2018Date of Patent: December 28, 2021Assignees: Kyowa Kirin Co., Ltd., The University of TokyoInventors: Kazuki Okada, Kiyotoshi Mori, Satoshi Uematsu, Naoki Takemura
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Patent number: 11007747Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.Type: GrantFiled: May 1, 2018Date of Patent: May 18, 2021Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Yusuke Goto, Masao Kamahori, Hiroshi Sasaki, Kiyotoshi Mori, Hideyuki Akiyama
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Patent number: 10828861Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.Type: GrantFiled: May 1, 2018Date of Patent: November 10, 2020Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Yusuke Goto, Masao Kamahori, Hiroshi Sasaki, Kiyotoshi Mori, Hideyuki Akiyama
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Publication number: 20200040088Abstract: A therapeutic or prophylactic agent for radiation damage associated with radiation exposure, comprising an eosinophil-removing agent as an active ingredient and the like are provided as a technique for efficiently treating or preventing radiation damage associated with radiation exposure. According to the therapeutic or prophylactic agent comprising an eosinophil-removing agent according to the present invention, by suppressing migration and/or infiltration into target tissue and/or proliferation in the tissue of eosinophils and/or inhibiting the activity or function of the eosinophils, pathological conditions such as inflammatory responses and fibrosis of tissue can be suppressed to effectively treat or prevent radiation damage. Moreover, effective radiation therapy can be performed by suppressing radiation damage.Type: ApplicationFiled: January 22, 2018Publication date: February 6, 2020Applicants: Kyowa Kirin Co., Ltd., The University of TokyoInventors: KAZUKI OKADA, KIYOTOSHI MORI, Satoshi UEMATSU, Naoki TAKEMURA
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Patent number: 10364900Abstract: Provided are: a flow path switching valve that reduces the pressure load in a contact surface outer peripheral section of the flow path switching valve and inhibits friction between constituent components; and a liquid chromatographic device using the flow path switching valve. The flow path switching valve is provided with a stator having a plurality of through holes and a seal having conduction grooves for causing the through holes to conduct. The seal has a first portion present vertically beneath a region comprising at least a surface of contact with the stator, and a second portion having lower rigidity than the first portion, on the outside of the first portion. Due to this configuration, it is possible to reduce the pressure load when a flow path of a liquid is switched under high-pressure conditions, and inhibit the phenomenon of friction itself.Type: GrantFiled: January 22, 2015Date of Patent: July 30, 2019Assignee: Hitachi High-Technologies CorporationInventors: Takaaki Hara, Hiroshi Moriya, Ayano Otsubo, Yoshihiro Nagaoka, Kiyotoshi Mori, Shoji Tomita
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Publication number: 20180244015Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.Type: ApplicationFiled: May 1, 2018Publication date: August 30, 2018Inventors: Yusuke GOTO, Masao KAMAHORI, Hiroshi SASAKI, Kiyotoshi MORI, Hideyuki AKIYAMA
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Publication number: 20180244014Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.Type: ApplicationFiled: May 1, 2018Publication date: August 30, 2018Inventors: Yusuke GOTO, Masao KAMAHORI, Hiroshi SASAKI, Kiyotoshi MORI, Hideyuki AKIYAMA
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Patent number: 9975308Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.Type: GrantFiled: November 1, 2013Date of Patent: May 22, 2018Assignee: Hitachi High-Technologies CorporationInventors: Yusuke Goto, Masao Kamahori, Hiroshi Sasaki, Kiyotoshi Mori, Hideyuki Akiyama
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Patent number: 9541531Abstract: A detector for liquid chromatography has light sources that generate light in an ultraviolet region and in a near-infrared region; a flow cell, through which sample liquid flows; an optical system to let light generated from the light sources become incident on the flow cell concurrently; a detection element that detects light in the ultraviolet region that passes through the flow cell; a detection element that detects light in the near-infrared region that passes through the flow cell; and an arithmetic operation part that performs arithmetic operation of a first signal value obtained from the detection element and of a second signal value obtained from the detection element. The arithmetic operation part combines the first signal value and the second signal value to calculate a signal value with a reduced baseline fluctuation resulting from a mobile phase during a gradient analysis.Type: GrantFiled: September 5, 2014Date of Patent: January 10, 2017Assignee: Hitachi High-Technologies CorporationInventors: Yusuke Goto, Masao Kamahori, Kiyotoshi Mori
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Publication number: 20160377184Abstract: Provided are: a flow path switching valve that reduces the pressure load in a contact surface outer peripheral section of the flow path switching valve and inhibits friction between constituent components; and a liquid chromatographic device using the flow path switching valve. The flow path switching valve is provided with a stator having a plurality of through holes and a seal having conduction grooves for causing the through holes to conduct. The seal has a first portion present vertically beneath a region comprising at least a surface of contact with the stator, and a second portion having lower rigidity than the first portion, on the outside of the first portion. Due to this configuration, it is possible to reduce the pressure load when a flow path of a liquid is switched under high-pressure conditions, and inhibit the phenomenon of friction itself.Type: ApplicationFiled: January 22, 2015Publication date: December 29, 2016Applicant: Hitachi High-Technologies CorporationInventors: Takaaki HARA, Hiroshi MORIYA, Ayano OTSUBO, Yoshihiro NAGAOKA, Kiyotoshi MORI, Shoji TOMITA
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Publication number: 20150314550Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.Type: ApplicationFiled: November 1, 2013Publication date: November 5, 2015Inventors: Yusuke GOTO, Masao KAMAHORI, Hiroshi SASAKI, Kiyotoshi MORI, Hideyuki AKIYAMA
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Patent number: 9110073Abstract: In a liquid chromatograph, the disulfide adsorption of iron atoms in a filter for a column is avoided and thus peak tailing in a chromatogram is prevented to thereby prevent a lowering in the sample recovery rate. A liquid chromatograph column comprising a hollow tubular column body, a bead-shaped packing material which is packed in the hollow part of the column body, a filter provided with a mesh which has a mesh size smaller than the particle diameter of the packing material, and a cap which presses the filter against the packing material to thereby enclose the packing material within the column body, characterized in that the main component of the filter is nickel or hastelloy.Type: GrantFiled: March 10, 2010Date of Patent: August 18, 2015Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Norimasa Minamoto, Masahito Ito, Kisaburo Deguchi, Hiroyuki Tanai, Kiyotoshi Mori
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Publication number: 20150090014Abstract: A detector for liquid chromatography has light sources that generate light in an ultraviolet region and in a near-infrared region; a flow cell, through which sample liquid flows; an optical system to let light generated from the light sources become incident on the flow cell concurrently; a detection element that detects light in the ultraviolet region that passes through the flow cell; a detection element that detects light in the near-infrared region that passes through the flow cell; and an arithmetic operation part that performs arithmetic operation of a first signal value obtained from the detection element and of a second signal value obtained from the detection element. The arithmetic operation part combines the first signal value and the second signal value to calculate a signal value with a reduced baseline fluctuation resulting from a mobile phase during a gradient analysis.Type: ApplicationFiled: September 5, 2014Publication date: April 2, 2015Inventors: Yusuke GOTO, Masao KAMAHORI, Kiyotoshi MORI
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Patent number: D692155Type: GrantFiled: August 7, 2012Date of Patent: October 22, 2013Assignee: Hitachi High-Technologies CorporationInventors: Kosuke Matoba, Mitsuru Oonuma, Masaru Tomioka, Kiyotoshi Mori, Akira Owada, Yoko Sato, Hiroyuki Noda
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Patent number: D692156Type: GrantFiled: August 7, 2012Date of Patent: October 22, 2013Assignee: Hitachi High-Technologies CorporationInventors: Kosuke Matoba, Mitsuru Oonuma, Masaru Tomioka, Kiyotoshi Mori, Akira Owada
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Patent number: D692157Type: GrantFiled: August 7, 2012Date of Patent: October 22, 2013Assignee: Hitachi High-Technologies CorporationInventors: Kosuke Matoba, Mitsuru Oonuma, Masaru Tomioka, Kiyotoshi Mori, Akira Owada
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Patent number: D692158Type: GrantFiled: August 7, 2012Date of Patent: October 22, 2013Assignee: Hitachi High-Technologies CorporationInventors: Kosuke Matoba, Mitsuru Oonuma, Masaru Tomioka, Kiyotoshi Mori, Akira Owada
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Patent number: D693938Type: GrantFiled: August 7, 2012Date of Patent: November 19, 2013Assignee: Hitachi High-Technologies CorporationInventors: Kosuke Matoba, Mitsuru Oonuma, Masaru Tomioka, Kiyotoshi Mori, Akira Owada, Yoko Sato, Yoshimasa Yokoyama