Abstract: A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.

Abstract: A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.

Abstract: Providing a patch case that is easily attached to a microneedle applicator, easily separable from the microneedle patch upon insertion and disposable for use. The main feature of the patch case according to the present invention is characterized in that it is made of a thermoplastic polymer and is capable of holding a microneedle patch comprising a support film which can be heat-sealed with the thermoplastic polymer. Preferably, the thermoplastic polymer of the body and the fusible material of the support film are both polyolefins or both are the same thermoplastic polymer. In addition, if the patch case is attached to the front of the applicator, sanitary situation can be maintained even with continuous use of the applicator, since the applicator does not contact the skin of the recipient.

Abstract: A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation which is composed of a liquid container and the nozzle.

Abstract: To provide a means which makes it possible to reliably administer a sheet-like water-soluble preparation to skins at various sites and supply water from a back side of the sheet-like water-soluble preparation. A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation, and having concave-convex portions on a portion of the plane excluding the hole; and an applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.

Abstract: Providing a patch case that is easily attached to a microneedle applicator, easily separable from the microneedle patch upon insertion and disposable for use. The main feature of the patch case according to the present invention is characterized in that it is made of a thermoplastic polymer and is capable of holding a microneedle patch comprising a support film which can be heat-sealed with the thermoplastic polymer. Preferably, the thermoplastic polymer of the body and the fusible material of the support film are both polyolefins or both are the same thermoplastic polymer. In addition, if the patch case is attached to the front of the applicator. sanitary situation can be maintained even with continuous use of the applicator, since the applicator does not contact the skin of the recipient.

Abstract: The present invention provides a spun yarn winding machine which enables the double support of bobbin holders including the time when yarn is switched and capable of lengthening the bobbin holders.A spun yarn winding machine in which two bobbin holders rotated and driven are projected on a turnable turret plate and, the bobbin holders are positioned alternately at a winding position and at a standby position, respectively, includes an extreme end support device for supporting extreme ends of the bobbin holders and at the winding position and at the standby position and capable of opening the extreme end of the bobbin holder at the standby position.