Patents by Inventor Kjeld Olesen

Kjeld Olesen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enterokinase cleavable polypeptides
    Patent number: 9982287
    Abstract: The present invention relates to Enterokinase-cleavable polypeptides comprising an Enterokinase cleavage site connected to a polypeptide and their use for making the target polypeptide by expression. The invention also relates to DNA sequences, vectors and host cells for use in expressing the Enterokinase-cleavable polypeptides.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 29, 2018
    Assignee: Novo Nordisk A/S
    Inventors: Kjeld Olesen, Jakob Brandt
  • ENTEROKINASE CLEAVABLE POLYPEPTIDES
    Publication number: 20160319321
    Abstract: The present invention relates to Enterokinase-cleavable polypeptides comprising an Enterokinase cleavage site connected to a polypeptide and their use for making the target polypeptide by expression. The invention also relates to DNA sequences, vectors and host cells for use in expressing the Enterokinase-cleavable polypeptides.
    Type: Application
    Filed: December 17, 2014
    Publication date: November 3, 2016
    Inventors: Kjeld Olesen, Jakob Brandt
  • MODIFIED CARBOXYPEPTIDASE
    Publication number: 20010010923
    Abstract: A method for transamidating a peptide substrate having a P1 amino acid residue with a positively charged side chain. According to the invention, carboxypeptidase Y is modified to substitute at least one amino acid having a negatively charged side chain in an S1 subsite. Additionally, the modified carboxypeptidase Y can include substituted amino acid residues in an S1′, S2 and/or S3 subsite to accommodate a specific peptide substrate.
    Type: Application
    Filed: October 19, 1999
    Publication date: August 2, 2001
    Inventors: UFFE MORTENSEN, KJELD OLESEN, HENNING STENNICKE, STEEN B. SORENSEN, KLAUS BREDDAM
  • Modified carboxypeptidase
    Patent number: 5985627
    Abstract: A method for transamidating a peptide substrate having a P.sub.1 amino acid residue with a positively charged side chain. According to the invention, carboxypeptidase Y is modified to substitute at least one amino acid having a negatively charged side chain in an S.sub.1 subsite. Additionally, the modified carboxypeptidase Y can include substituted amino acid residues in an S.sub.1 ', S.sub.2 and/or S.sub.3 subsite to accommodate a specific peptide substrate.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: November 16, 1999
    Assignee: Carlsberg Laboratory
    Inventors: Uffe Mortensen, Kjeld Olesen, Henning Stennicke, Steen B. S.o slashed.rensen, Klaus Breddam