Abstract: The invention relates to a lock comprising a housing (14, 55), a key operated lock cylinder (13, 51), which is arranged rotatable in the lock housing and a lock catch (11, 60), which is connected to the lock cylinder and rotatable between a locking position and a releasing position. The lock is arranged to be selectively set in a key operated mode, wherein the lock catch is rotatable with the lock cylinder, or in a push button operated mode, wherein the lock catch is movable by axial displacement of the lock cylinder.

Abstract: A chromatography column including: a tubular housing; a first end unit removably connected to a first end of the tubular housing; a second end unit removably connected to a second end of the tubular housing; an adaptor assembly movable within said tubular housing; an adaptor rod connected to said adaptor assembly, which adaptor rod is arranged to extend through an opening in the first end unit; a filter removably connected to the adaptor assembly; and a frame connected to said tubular housing for supporting the column on a floor. At least an actuating means is arranged on the frame, so that the column can be lifted and lowered in a substantially vertical direction.

Abstract: An adaptor for a chromatography column, the adaptor comprising a substantially circular bottom plate provided with an end surface; a ring shaped wall element arranged at the periphery of the bottom plate. The bottom plate and the wall element having a common axis and the adaptor is provided with a filter connection arrangement for removably connecting a filter on the end surface of the bottom plate of the adaptor.

Abstract: A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device.

Abstract: A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device.

Abstract: The present invention relates to methods for conducting maintenance on chromatography columns used in industrial-scale chromatography. In particular, the invention is concerned with safer methods for performing maintenance on such columns, such as cleaning and replacing bed supports, distributors, nozzles, O-rings and other column components, by the use of a handling device to support, lift, carry and manipulate such column components.

Abstract: The present invention is within the field of biomolecule purification. More closely the invention relates to chromatographic purification of insulin using a specific kind of shell beads having an inner core and an outer functionalized layer. The method enables purification at high flow rates and high purity, over 90%.

Abstract: A lockable container arrangement includes an interior and an exterior, the container includes a base part, a cover pivotally attached to the base part for displacement between a closed position in which the cover and the base delimit a substantially enclosed space and an open position, a lock mounted on the container, the lock including a lock catch operable from the exterior of the container, which lock catch engages a receiving portion to lock the container. The container arrangement can be selectively set in a key operated mode where the lock catch is operable by a key, or in a push button operated mode where the lock catch is operable by the application of a force onto the lock by a user.

Abstract: A method of maintenance of a chromatography column is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. The provision of guide elements which can be reversibly attached to the column facilitates removal or insertion of column components.

Abstract: A method of maintenance of a chromatography column is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. The provision of guide elements which can be reversibly attached to the column facilitates removal or insertion of column components.

Abstract: A method of maintenance of a chromatography column is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. The provision of guide elements which can be reversibly attached to the column facilitates removal or insertion of column components.

Abstract: A method of maintenance of a chromatography column is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. The provision of guide elements which can be reversibly attached to the column facilitates removal or insertion of column components.

Abstract: The invention relates to a lock comprising a housing (14, 55), a key operated lock cylinder (13, 51), which is arranged rotatable in the lock housing and a lock catch (11, 60), which is connected to the lock cylinder and rotatable between a locking position and a releasing position. The lock is arranged to be selectively set in a key operated mode, wherein the lock catch is rotatable with the lock cylinder, or in a push button operated mode, wherein the lock catch is movable by axial displacement of the lock cylinder.

Abstract: A lockable container arrangement includes an interior and an exterior, the container includes a base part, a cover pivotally attached to the base part for displacement between a closed position in which the cover and the base delimit a substantially enclosed space and an open position, a lock mounted on the container, the lock including a lock catch operable from the exterior of the container, which lock catch engages a receiving portion to lock the container. The container arrangement can be selectively set in a key operated mode where the lock catch is operable by a key, or in a push button operated mode where the lock catch is operable by the application of a force onto the lock by a user.

Abstract: The present invention relates to a method of separating one or more monomeric proteins, such as monomeric antibodies, from a liquid. The method comprises providing a thiophilic aromatic chromatography matrix; contacting the liquid that comprises proteins with the matrix; and recovering at least one monomeric protein, such as a monomeric antibody, from the flow-through fraction. The proteins are advantageously monomeric antibodies.

Abstract: Financial instruments incentivize the development of low income real property by retaining profitability similar to property sold at fair market value. A REEIP is proposed wherein investors profit by receiving units of real property at a substantial discount that may be subsequently sold or rented after title passes to the investor. A construction fees, costs, or tax instrument are built into each real property unit and issued as a second or subsequent mortgage for all fees and compliance costs, which allows the purchaser of the real property to purchase the real property at a discount by removing the fees and compliance costs from the purchase price of the real property. Finally, real property may be sold to qualifying low income purchasers by allowing a developer to gradually turn over equity in a low income home to the purchaser over a predetermined time period, which is secured by a forgivable mortgage.

Abstract: The present invention relates to a method of isolating fully thioated single stranded antisense oligonucleotides from a biological solution, which method comprises the steps of contacting the biological solution with an immobilised metal ion adsorption chromatography (IMAC) resin to adsorb the antisense oligonucleotides to the resin and subsequently contacting the resin with an eluent under conditions that provide desorption of the antisense oligonucleotides from the resin, wherein the fully thioated antisense oligonucleotides are separated from incorrectly thioated antisense oligonucleotides in the solution. The invention also relates to the use of an immobilised metal ion adsorption chromatography (IMAC) resin for isolation of fully thioated single stranded antisense oligonucleotides from a biological solution.

Abstract: The present invention relates to a method of isolating fully thioated single stranded antisense oligonucleotides from a biological solution, which method comprises the steps of contacting the biological solution with an immobilised metal ion adsorption chromatography (IMAC) resin to adsorb the antisense oligonucleotides to said resin and subsequently contacting the resin with an eluent under conditions that provide desorption of the antisense oligonucleotides from said resin, wherein the fully thioated antisense oligonucleotides are separated from incorrectly thioated antisense oligonucleotides in said solution. The invention also relates to the use of an immobilised metal ion adsorption chromatography (IMAC) resin for isolation of fully thioated single stranded antisense oligonucleotides from a biological solution.

Abstract: In a plant for generating electric power through at least two generators separately driven by wind power and feeding an alternating voltage to an alternating voltage line in common, a converter is adapted to convert the alternating voltage into direct voltage and conversely. The plant has means (29, 30) adapted to measure the total power fed towards the converter from the wind power generators and members (32) adapted to send orders to a unit (14) adapted to control the converter (9) for adjusting the control thereof depending upon power values delivered by said means to such a frequency that a power maximum is obtained.