Abstract: A structurally-modified recombinant protein, obtained by a method comprising generating at least one genetic construct comprising a nucleotide sequence coding for the protein comprising a recognition sequence; expressing in a host the at least one genetic construct using a vector comprising the at least one genetic construct; and using a plant-based expression system with the vector to express the protein, the plant-based expression system being a plant or a plant cells suspension; the recognition sequence comprises a sequence Phe-x1-x2-Tyr, wherein Phe is phenylalanine, x1 and x2 are amino acid residues, and Tyr is tyrosine and the plant-based expression system has an inherent enzymatic activity which converts the phenylalanine residue of the recognition sequence into a didehydrophenylalanine residue, producing a structurally-modified recombinant protein; and isolating the protein with the recognition sequence which is a part of the protein, the phenylalanine being converted to a didehydrophenylalanine from

Abstract: The invention is directed to a method for producing conformational-stabilized proteins by incorporating a recognition sequence in a protein, the method comprising the steps of (a) generating at least one genetic construct comprising the recognition sequence; (b) expressing in a natural host the at least one genetic construct using oligonucleotide primers, thereby forming a vector; and (c) using a plant-based over-expression system with a constitutive promoter to over-express the vector. The method is remarkable in that the recognition sequence comprises at least one stretch of amino acids with as sequence Phe-x1-x2-Tyr, wherein Phe is phenylalanine, X1 and X2 are amino acid residues and Tyr is tyrosine.