Abstract: Methods and systems for motion-corrected and motion-compensated laser speckle contrast imaging are disclosed which comprise exposing a target area to coherent first light of a first wavelength, the target area including living tissue, and capturing at least one sequence of images comprising first speckle images and determining one or more transformation parameters of an image registration algorithm for registering the first speckle images with each other. The transformation parameters may be based on a similarity measure of pixel values of groups of pixels in a plurality of images of the at least one sequence of images the images in the plurality of images being selected from the first speckle images or being associated with the first speckle images.

Abstract: An implantable injection chamber device comprising a housing which encloses an injection chamber and has at least one wall that can be pierced with a hollow needle, and a bore provided in a wall of the chamber, there being further provided connecting means for connecting a catheter to the bore, and in which the connecting means comprise a tube of pliable material which is connected to the bore and in operation extends through a bore in a first member of the connecting means, at least a part of said first member surrounding the tube relatively tightly and said part being provided with a plurality of radially disposed longitudinal grooves; and a second member of the connecting means is provided, which in operation surrounds the part of the first member that is provided with longitudinal grooves and is capable of pressing inwardly the parts of the first member between the longitudinal grooves.