Abstract: A high-sensitivity acquisition involves a (dynamic) steady-state that is achieved by repetitive applying flip angles with the same sign. Read-out of the magnetic resonance signals is done in the form of gradient echoes that are generated by applying temporary magnetic gradient fields. Preferably, all gradients are completely compensated for Accordingly, a so-called Rephased Fast-Field Echo (R-FFE) sequence employed as the high-sensitivity acquisition sequence. It appears that a high-sensitivity is achieved when a flip angle in the range from 3° to 15° is employed. High-sensitivity is achieved for very low concentrations of contrast agent in a range suitable for molecular imaging.

Abstract: The present invention provides means and methods for at least a partial prevention of cellular damage in disease resulting from hypoxia/ischemia (H/I)-related inflammation, preferably due to occlusion of blood vessels. Administration of IFN type-I before, around or after the time of lifting of the ischemia results in improved survival of cells downstream of the occluded blood vessel, presumable because the H/I-related inflammation is attenuated. Treatment results in less damage, better recovery and/or improved repair of the affected tissue.

Abstract: The present invention provides means and methods for at least a partial prevention of cellular damage in disease resulting from H/I-related blood flow resistance, preferably due to occlusion of blood vessels. Administration of &bgr;-interferon before, around or after the time of lifting of the ischemia results in improved survival of cells downstream of the occluded blood vessel, presumable because micro-vasculature downstream of the lifted obstruction if prevented from clogging. Prevention of blood flow impairment presumably leads to increased survival of cells in tissue affected by the ischemia.