Patents by Inventor Klaus B. Himmeldirk

Klaus B. Himmeldirk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PGG separation and purification
    Patent number: 8357796
    Abstract: A simple, inexpensive, and efficient method for separation and purification of the ?-and ?-forms of penta-O-galloyl-D-glucose (PGG) without the need for HPLC. The methods provided herein are useful for separation ?-PGG or ?-PGG from a mixture containing ?-PGG and ?-PGG and other chemicals. The method for separation of ?-PGG from a mixture of ?-PGG and ?-PGG comprises the steps of: adding water to a sample containing 50% or more ?-PGG and 50% or less ?-PGG; mixing the PGG and water to dissolve the PGG; filtering out any undissolved particles; and allowing the filtered solution to stand undisturbed until crystals form.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: January 22, 2013
    Assignee: Ohio University
    Inventors: Yulin Ren, Klaus B. Himmeldirk, Xiaozhou Chen
  • Efficient method to synthesize benzyl group-protected alpha-pentagalloylglucose (?-PGG) and its analogues
    Patent number: 7772381
    Abstract: A method to synthesize benzyl group protected alpha-pentagalloylglucose (?-PGG) and related compounds. The method comprises the steps of: suspending a highly reactive acylation agent and an acylating catalyst in a donor solvent; adding ?-D-glucose or an analogue thereof to the mixture; reacting the mixture at room temperature for a time sufficient for reaction to occur; evaporating the solvent; taking up the residue in an appropriate solvent; filtering the residue and solvent mixture; and evaporating off the solvent.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: August 10, 2010
    Assignee: Ohio University
    Inventors: Klaus B. Himmeldirk, Xiaozhou Chen
  • Efficient Method To Synthesize Benzyl Group-Protected Alpha-Pentagalloylglucose (Alpha-Pgg) And Its Analogues
    Publication number: 20080319185
    Abstract: A method to synthesize benzyl group protected alpha-pentagalloylglucose (?-PGG) and related compounds. The method comprises the steps of: suspending a highly reactive acylation agent and an acylating catalyst in a donor solvent; adding ?-D-glucose or an analogue thereof to the mixture; reacting the mixture at room temperature for a time sufficient for reaction to occur; evaporating the solvent; taking up the residue in an appropriate solvent; filtering the residue and solvent mixture; and evaporating off the solvent.
    Type: Application
    Filed: January 24, 2005
    Publication date: December 25, 2008
    Applicant: Ohio University
    Inventors: Klaus B. Himmeldirk, Xiaozhuo Chen
  • Pgg Separation and Purification
    Publication number: 20080249299
    Abstract: A simple, inexpensive, and efficient method for,separation and purification of the ?- and ?-FORMS OF penta-O-galloyl-D-glucose (PGG) without the need for HPLC. The methods provided herein are useful for separating ?-PGG or ?-PGG from a mixture that contains ?-PGG and ?-PGG and other chemicals. The method for separation of ?-PGG from a mixture of ?-PGG and ?-PGG comprises the steps of adding water to a sample containing 50% or morec ?-PGG and 50% or less ?-PGG; mixing the PGG and watcr to dissolve thc, PGG; filtering out any undissolvcd particles; and allowing the filtercd solution to stand undisturbcd until crystals form.
    Type: Application
    Filed: January 24, 2005
    Publication date: October 9, 2008
    Applicant: Ohio University
    Inventors: Yulin Ren, Klaus B. Himmeldirk, Xiaozhuo Chen