Patents by Inventor Klaus B. Simonsen

Klaus B. Simonsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7964724
    Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: June 21, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Patent number: 7705007
    Abstract: There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: April 27, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Patent number: 7579368
    Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: August 25, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Publication number: 20090143364
    Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
    Type: Application
    Filed: February 5, 2009
    Publication date: June 4, 2009
    Inventors: Nader Fotouhi, Gregory Jay Haley, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Patent number: 7425638
    Abstract: The present invention provides compounds according to formula I having the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: September 16, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gregory Jay Haley, Norman Kong, Emily Aijun Liu, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber
  • Patent number: 7223759
    Abstract: The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of using such compounds in the treatment of bacterial infections in mammals, especially humans.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: May 29, 2007
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Yuefen Zhou, Dionisios Vourloumis, Vlad E. Gregor, Geoffrey C. Winters, Thomas Hermann, Benjamin Ayida, Zhongxiang Sun, Douglas Murphy, Klaus B. Simonsen
  • Publication number: 20040259884
    Abstract: The present invention provides compounds according to formula I 1
    Type: Application
    Filed: June 14, 2004
    Publication date: December 23, 2004
    Inventors: Gregory Jay Haley, Norman Kong, Emily Aijun Liu, Klaus B. Simonsen, Binh Thanh Vu, Stephen Evan Webber