Patents by Inventor Klaus Bornemann

Klaus Bornemann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds
    Patent number: 7534787
    Abstract: A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ? peptides (A?) and/or with a changed ratio of levels of A? isoforms and/or with the formation of plaques containing amyloid ? peptide (A?) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: May 19, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Klaus Bornemann, Guenter Trummlitz, Bernd Beck, Frank Sams-Dodd, Dagmar Kugler, Klaus Klinder, Cornelia Dorner-Ciossek, Marcus Kostka
  • Method of Treating Diseases and Conditions Associated with an Altered Level of Amyloid Beta Peptides and New Enolcarboxamide Compounds
    Publication number: 20090099159
    Abstract: A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ? peptides (A?) and/or with a changed ratio of levels of A? isoforms and/or with the formation of plaques containing amyloid ? peptide (A?) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
    Type: Application
    Filed: December 17, 2008
    Publication date: April 16, 2009
    Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
    Inventors: Klaus BORNEMANN, Guenter TRUMMLITZ, Bernd BECK, Frank SAMS-DODD, Dagmar KUGLER, Klaus KLINDER, Cornelia DORNER-CIOSSEK, Marcus KOSTKA
  • Substituted Ethane-1,2-Diamines for the Treatment of Alzheimer's Disease II
    Publication number: 20080293680
    Abstract: The invention relates to a compound of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: August 1, 2006
    Publication date: November 27, 2008
    Inventors: Stefan Peters, Christian Eickmeier, Klaus Fuchs, Werner Stransky, Cornelia Dorner-Ciossek, Marcus Kostka, Sandra Handschuh, Herbert Nar, Klaus Bornemann, Klaus Klinder, Margit Bauer
  • Method of treating diseases and conditions associated with an altered level of amyloid ? peptides and new enolcarboxamide compounds
    Patent number: 7393843
    Abstract: A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ? peptides (A?) and/or with a changed ratio of levels of A? isoforms and/or with the formation of plaques containing amyloid ? peptide (A?) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: July 1, 2008
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Klaus Bornemann, Guenter Trummlitz, Bernd Beck, Frank Sams-Dodd, Dagmar Kugler, Klaus Klinder, Cornelia Dorner-Clossek, Marcus Kostka
  • Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds
    Publication number: 20080139541
    Abstract: A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ? peptides (A?) and/or with a changed ratio of levels of A? isoforms and/or with the formation of plaques containing amyloid D peptide (A?) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
    Type: Application
    Filed: January 17, 2008
    Publication date: June 12, 2008
    Inventors: Klaus Bornemann, Guenter Trummlitz, Bernd Beck, Frank Sams-Dodd, Dagmar Kugler, Klaus Klinder, Cornelia Dorner-Ciossek, Marcus Kostka
  • Method of treating diseases and conditions associated with an altered level of amyloid ? peptides and new enolcarboxamide compounds
    Patent number: 7375220
    Abstract: A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ? peptides (A?) and/or with a changed ratio of levels of A? isoforms and/or with the formation of plaques containing amyloid ? peptide (A?) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: May 20, 2008
    Assignees: Boehringer Ingelheim Vetmedica GmbH, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Klaus Bornemann, Guenter Trummlitz, Edward S. Lazer, Clara K. Miao, Bernd Beck, Frank Sams-Dodd, Dagmar Kugler, Klaus Klinder, Cornelia Dorner-Ciossek, Marcus Kostka
  • Trisubstituted pyrimidines
    Patent number: 7166599
    Abstract: The present invention relates to trisubstituted pyrimidines of formula wherein Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses in which ?-amyloid modulators have a therapeutic benefit, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: January 23, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Klaus Bornemann, Hans Briem, Cornelia Dorner-Ciossek, Katja Fechteler, Klaus Fuchs, Frank Himmelsbach, Klaus Klinder, Markus Kostka
  • Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds
    Publication number: 20060040928
    Abstract: A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ? peptides (A?) and/or with a changed ratio of levels of A? isoforms and/or with the formation of plaques containing amyloid ? peptide (A?) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
    Type: Application
    Filed: May 19, 2005
    Publication date: February 23, 2006
    Applicants: Boehringer Ingelheim Vetmedica GmbH, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Klaus Bornemann, Guenter Trummlitz, Edward Lazer, Clara Miao, Bernd Beck, Frank Sams-Dodd, Dagmar Kugler, Klaus Klinder, Cornelia Dorner-Ciossek, Marcus Kostka
  • Substituted ethane-1,2-diamines for the treatment of Alzheimer's disease
    Publication number: 20060025345
    Abstract: The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, A, B, and Y are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: May 20, 2005
    Publication date: February 2, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Stefan Peters, Christian Eickmeier, Klaus Fuchs, Werner Stransky, Cornelia Dorner-Ciossek, Marcus Kostka, Sandra Handschuh, Margit Bauer, Herbert Nar, Klaus Bornemann, Klaus Klinder, Joerg Rademann, Steffen Weik
  • Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid generation
    Publication number: 20050277664
    Abstract: The invention relates to the use of a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety for the preparation of a medicament for inhibiting ?-amyloid generation.
    Type: Application
    Filed: June 3, 2005
    Publication date: December 15, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Klaus Bornemann, Joachim Mierau, Dagmar Kugler
  • Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds
    Publication number: 20050277635
    Abstract: A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ? peptides (A?) and/or with a changed ratio of levels of A? isoforms and/or with the formation of plaques containing amyloid ? peptide (A?) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
    Type: Application
    Filed: May 19, 2005
    Publication date: December 15, 2005
    Applicants: Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Klaus Bornemann, Guenter Trummlitz, Bernd Beck, Frank Sams-Dodd, Dagmar Kugler, Klaus Klinder, Cornelia Dorner-Ciossek, Marcus Kostka
  • Trisubstituted pyrimidines
    Publication number: 20050090486
    Abstract: The present invention relates to trisubstituted pyrimidines of formula wherein Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses in which ?-amyloid modulators have a therapeutic benefit, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.
    Type: Application
    Filed: December 9, 2004
    Publication date: April 28, 2005
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Klaus Bornemann, Hans Briem, Cornelia Dorner-Ciossek, Katja Fechteler, Klaus Fuchs, Frank Himmelsbach, Klaus Klinder, Markus Kostka
  • Trisubstituted pyrimidines
    Publication number: 20030134838
    Abstract: The present invention relates to trisubstituted pyrimidines of formula 1
    Type: Application
    Filed: October 16, 2002
    Publication date: July 17, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Klaus Bornemann, Hans Briem, Cornelia Dorner-Clossek, Katja Fechteler, Klaus Fuchs, Frank Himmelsbach, Klaus Klinder, Markus Kostka
  • Muscarinic M1 agonist as an inhibitor of beta-amyloid (A&bgr;40 and A&bgr;42)-synthesis
    Patent number: 6573276
    Abstract: Methods of lowering the levels of A&bgr;40, A&bgr;42 and tau protein in a mammal comprising administering to the mammal an effective amount of talsaclidine, or a physiologically acceptable acid addition salt thereof, and methods of treating diseases associated with the formation of diffuse and senile plaques or A&bgr;40-, A&bgr;42- and tau-containing plaques are disclosed.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: June 3, 2003
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Christoph Hock, Andreas Raschig, Marion Wienrich, Roger Nitsch, Klaus Mendla, Dieter Horst Meier, Klaus Bornemann, Cornelia Dorner-Ciossek
  • Muscarinic M1 agonist as an inhibitor of beta-amyloid (ABeta40 and ABeta42)-synthesis
    Publication number: 20030050221
    Abstract: A method of lowering the levels of A&bgr;40, A&bgr;42, and tau protein in a mammal comprising administering to the mammal an effective amount of talsaclidine or a physiologically acceptable acid addition salt thereof and methods of treating or preventing diseases associated with the formation of diffuse and senile plaques or A&bgr;40-, A&bgr;42- and tau-containing plaques.
    Type: Application
    Filed: April 30, 2002
    Publication date: March 13, 2003
    Inventors: Christoph Hock, Andreas Raschig, Marion Wienrich, Roger Nitsch, Klaus Mendla, Dieter Horst Meier, Klaus Bornemann, Cornelia Dorner-Ciossek