Patents by Inventor Klaus Dembowsky

Klaus Dembowsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Publication number: 20040067945
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Application
    Filed: February 12, 2003
    Publication date: April 8, 2004
    Inventors: Ulrich Niewohner, Maria Niewohner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jorg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • Novel sulfonamide-substituted pyrazolopyridine derivatives
    Publication number: 20040067937
    Abstract: The invention relates to novel pyrazolopyridine derivatives of formula (I) wherein R1 represents H, Cl or NH2, and R2 and R3 form; together with the heteroatoms to which they are bonded, a five to six-membered heterocycle which can be saturated or partially unsaturated, can optionally contain at least one other heteroatom from the group N, O, S and can be optionally substituted. The invention also relates to salts, isomers and hydrates of said derivatives, in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system.
    Type: Application
    Filed: October 23, 2003
    Publication date: April 8, 2004
    Inventors: Johannes-Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
  • Pyridine-substituted pyrazolopyridine derivatives
    Patent number: 6693102
    Abstract: The present invention relates to new pyrazolopyridine derivatives of the formula (I) in which R1 represents 4-pyridinyl or 3-pyridinyl; R2 represents H, NH2 or halogen; and salts, isomers and hydrates thereof as stimulators of soluble guanylate cyclase and for use as agents for the treatment of cardiovascular disorders, hypertension, of thromboembolic disorders and ischaemia, sexual dysfunction or inflammation, and for the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: February 17, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Johannes-Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
  • Triazolotriazinones and the use thereof
    Patent number: 6683081
    Abstract: The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: January 27, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Triazolotriazinones and the use thereof
    Publication number: 20030212064
    Abstract: The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof.
    Type: Application
    Filed: October 21, 2002
    Publication date: November 13, 2003
    Inventors: Ulrich Niewohner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Novel imidazo[1,3,5]triazinones and the use thereof
    Publication number: 20030195210
    Abstract: The invention relates to novel imidazo[1,3,5]triazinones of the general formula (I), to a method for their production and to their use as medicaments, in particular as inhibitors of cyclic GMP metabolising phosphodiesterases.
    Type: Application
    Filed: November 4, 2002
    Publication date: October 16, 2003
    Inventors: Ulrich Niewhner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Isoxazolo pyrimidinones and the use thereof
    Publication number: 20030149033
    Abstract: The invention relates to novel isoxazolo pyrimidinones of general formula (I), a method for producing the same and the pharmaceutical use thereof.
    Type: Application
    Filed: October 22, 2002
    Publication date: August 7, 2003
    Inventors: Ulrich Niewohner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • 2-phenyl substituted imidatriazinones as phosphodiesterase inhibitors
    Patent number: 6566360
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: May 20, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jörg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • Pyridine-substituted pyrazolopyridine derivatives
    Publication number: 20020173514
    Abstract: The present invention relates to new pyrazolopyridine derivatives of the formula (I) 1
    Type: Application
    Filed: November 1, 2001
    Publication date: November 21, 2002
    Inventors: Johannes-Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
  • 7-alkyl- and cycloalkyl-substituted imidazotriazinones
    Patent number: 6476029
    Abstract: The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: November 5, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
  • Heterocyclylmethyl-substituted pyrazole derivatives
    Patent number: 6462068
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: October 8, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Fürstner, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Dieter Arlt
  • Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases
    Patent number: 6451805
    Abstract: The present invention relates to new substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: September 17, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Fürstner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky
  • Heterocyclylmethyl-substituted pyrazol derivatives
    Patent number: 6414009
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: July 2, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Fürstner, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Dieter Arlt
  • Heterocyclylmethyl-substituted pyrazol derivatives
    Patent number: 6410740
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: June 25, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Fürstner, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Dieter Arlt
  • Heterocyclylmethyl-substituted pyrazole derivatives
    Patent number: 6387940
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: May 14, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Fürstner, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Dieter Arlt
  • 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Patent number: 6362178
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: March 26, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jörg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems
    Patent number: 6180656
    Abstract: The present invention relates to the new use of 1-benzyl-3-(substituted hetaryl)-fused pyrazole derivatives, some of which are known, of the general formula (I) in which R1 to R4 have the meaning indicated in the description, as medicaments, and to new active compounds, in particular to their use as vasodilators, if appropriate in combination with organic nitrates and NO donors and if appropriate in combination with compounds which inhibit the degradation of cGMP.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: January 30, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Chantal F{umlaut over (u)}rstner, Alexander Straub, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim H{umlaut over (u)}tter, Klaus Dembowsky
  • Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases
    Patent number: 6166027
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: December 26, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Furstner, Ulrich Niewohner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hutter, Klaus Dembowsky, Dieter Arlt
  • 4-bicyclically substituted dihydropyridines, and their use in medicaments
    Patent number: 5721248
    Abstract: The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
    Type: Grant
    Filed: May 10, 1996
    Date of Patent: February 24, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Siegfried Goldmann, Jurgen Stoltefuss, Martin Bechem, Klaus Dembowsky, Rainer Gross, Siegbert Hebisch, Joachim Hutter, Howard-Paul Rounding
  • 4-bicyclically substituted dihydropyridines and their use in medicaments
    Patent number: 5545646
    Abstract: The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: August 13, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Siegfried Goldmann, J urgen Stoltefuss, Martin Bechem, Klaus Dembowsky, Rainer Gross, Siegbert Hebisch, Joachim H utter, Howard-Paul Rounding