Patents by Inventor Klaus-Dieter Kühn
Klaus-Dieter Kühn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190192740Abstract: An implant is provided having an antibiotic coating that is inexpensive and easy to manufacture. The antibiotic coating adheres well and in stable manner to the surface of the implant, can be degraded by the body without forming toxic products, prevents the crystallization of the antibiotics in the coating, and ensures a high immediate locally-effective antibiotic concentration at the implant site. A coating solution useful for making the implant and a method for the manufacture of the implant are also described.Type: ApplicationFiled: February 22, 2019Publication date: June 27, 2019Inventors: Sebastian VOGT, Hubert BÜCHNER, Klaus-Dieter KÜHN
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Patent number: 9833472Abstract: The invention proposes an antiseptic composition for use as bone cement, in particular an antiseptic polymethylmethacrylate bone cement, that can be cured and comprises a content of at least one component that is a compound with an oxidizing effect or from which a compound with an oxidizing effect can be released. Preferably, hydrogen peroxide is or can be released. In this context, it is particularly preferred to use an adduct or a salt of hydrogen peroxide that releases hydrogen peroxide in the presence of water or aqueous conditions. The antiseptic polymethylmethacrylate bone cement can be used for mechanical fixation of primary total articular endoprostheses, for mechanical fixation of revision total articular endoprostheses, and for producing spacers.Type: GrantFiled: November 15, 2013Date of Patent: December 5, 2017Assignee: HERAEUS MEDICAL GMBHInventors: Sebastian Vogt, Klaus-Dieter Kühn
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Patent number: 9700657Abstract: The invention relates to a composite material that comprises at least one magnesium component, whereby the magnesium component consists of pure magnesium or a magnesium-calcium alloy or a magnesium-calcium-X alloy, whereby X is another biodegradable element. The composite material also contains at least one organic anti-infective agent having a solubility in water at room temperature of less than 10 grams per liter.Type: GrantFiled: July 22, 2014Date of Patent: July 11, 2017Assignees: HERAEUS MEDICAL GMBH, MEDIZINISCHE UNIVERSITÄT GRAZInventors: Klaus-Dieter Kühn, Annelie Weinberg, Peter Uggowitzer, Sebastian Vogt, Jörg Löffler
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Patent number: 9480778Abstract: A method for coating at least regions of a medical implant includes providing a medical implant having a surface to be coated, and immersing the surface of the medical implant into a liquid including at least one pharmaceutically active substance, whereby the liquid is transferred to the surface of the medical implant due to the immersing. The method also includes pulling the surface of the medical implant out of the liquid, whereby part of the liquid remains adhering to the surface of the medical implant.Type: GrantFiled: December 21, 2011Date of Patent: November 1, 2016Assignee: Heraeus Medical GmbHInventors: Sebastian Vogt, Klaus-Dieter Kühn
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Patent number: 9241746Abstract: The invention relates to an anti-infective spacer for osteosynthesis plates comprising a plate having at least one opening for accommodating a screw, whereby the plate is made up of at least one biocompatible material, in which at least one antimicrobial substance is distributed, dispersed or dissolved. The invention also relates to a set comprising at least one osteosynthesis plate and at least one said spacer, preferably comprising at least one screw for each recess of each spacer.Type: GrantFiled: March 13, 2013Date of Patent: January 26, 2016Assignee: Heraeus Medical GmbHInventors: Sebastian Vogt, Klaus-Dieter Kühn
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Patent number: 9078959Abstract: A device for coating at least regions of a medical implant includes an elastically deformable transfer means having a liquid that contains at least one pharmaceutically active substance. The liquid can be transferred to the medical implant when the transfer means is contacted with a surface of the medical implant.Type: GrantFiled: December 20, 2011Date of Patent: July 14, 2015Assignee: Heraeus Medical GmbHInventors: Sebastian Vogt, Klaus-Dieter Kühn
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Patent number: 8962008Abstract: The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of poly(hydroxyalkanoate)s, poly(lactic acid)s, poly(glycolic acid)s, poly(caprolactone)s and copolymers and blends thereof, wherein the biocompatible polyester material is crosslinked with a functionalized poly(alkylene oxide) having at least two functional groups independently selected from the group consisting of azido-formate and alkanoyl azide. The novel polymeric material with enhanced hydrophilicity is useful as a biocompatible material in a variety of medical applications, including medical implants, bioresorbable implants, tissue engineering, and controlled release.Type: GrantFiled: June 20, 2012Date of Patent: February 24, 2015Assignees: Technische Universitat Graz, Medical University of Graz MUG, AT&S Austria Technologie & Systemtechnik Aktiengesellschaft, Herabus Medical GmbHInventors: Frank Wiesbrock, Clemens Ebner, Franz Stelzer, Annelie-Martina Weinberg, Klaus-Dieter Kühn
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Publication number: 20150032201Abstract: The invention relates to a composite material that comprises at least one magnesium component, whereby the magnesium component consists of pure magnesium or a magnesium-calcium alloy or a magnesium-calcium-X alloy, whereby X is another biodegradable element. The composite material also contains at least one organic anti-infective agent having a solubility in water at room temperature of less than 10 grams per liter.Type: ApplicationFiled: July 22, 2014Publication date: January 29, 2015Applicants: MEDIZINISCHE UNIVERSITÄT GRAZ, HERAEUS MEDICAL GMBHInventors: KLAUS-DIETER KÜHN, ANNELIE WEINBERG, PETER UGGOWITZER, SEBASTIAN VOGT, JÖRG LÖFFLER
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Publication number: 20140228449Abstract: The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of poly(hydroxyalkanoate)s, poly(lactic acid)s, poly(glycolic acid)s, poly(caprolactone)s and copolymers and blends thereof, wherein the biocompatible polyester material is crosslinked with a functionalized poly(alkylene oxide) having at least two functional groups independently selected from the group consisting of azido-formate and alkanoyl azide. The novel polymeric material with enhanced hydrophilicity is useful as a biocompatible material in a variety of medical applications, including medical implants, bioresorbable implants, tissue engineering, and controlled release.Type: ApplicationFiled: June 20, 2012Publication date: August 14, 2014Applicant: Technische Universitat GrazInventors: Frank Wiesbrock, Clemens Ebner, Franz Stelzer, Annelie-Martina Weinberg, Klaus-Dieter Kühn
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Publication number: 20140141097Abstract: The invention proposes an antiseptic composition for use as bone cement, in particular an antiseptic polymethylmethacrylate bone cement, that can be cured and comprises a content of at least one component that is a compound with an oxidising effect or from which a compound with an oxidising effect can be released. Preferably, hydrogen peroxide is or can be released. In this context, it is particularly preferred to use an adduct or a salt of hydrogen peroxide that releases hydrogen peroxide in the presence of water or aqueous conditions. The antiseptic polymethylmethacrylate bone cement can be used for mechanical fixation of primary total articular endoprostheses, for mechanical fixation of revision total articular endoprostheses, and for producing spacers.Type: ApplicationFiled: November 15, 2013Publication date: May 22, 2014Applicant: HERAEUS MEDICAL GMBHInventors: Sebastian VOGT, Klaus-Dieter Kühn
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Publication number: 20130267954Abstract: The invention relates to an anti-infective spacer for osteosynthesis plates comprising a plate having at least one opening for accommodating a screw, whereby the plate is made up of at least one biocompatible material, in which at least one antimicrobial substance is distributed, dispersed or dissolved. The invention also relates to a set comprising at least one osteosynthesis plate and at least one said spacer, preferably comprising at least one screw for each recess of each spacer.Type: ApplicationFiled: March 13, 2013Publication date: October 10, 2013Inventors: Sebastian Vogt, Klaus-Dieter Kühn
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Publication number: 20120164309Abstract: A device for coating at least regions of a medical implant includes an elastically deformable transfer means having a liquid that contains at least one pharmaceutically active substance. The liquid can be transferred to the medical implant when the transfer means is contacted with a surface of the medical implant.Type: ApplicationFiled: December 20, 2011Publication date: June 28, 2012Applicant: HERAEUS MEDICAL GMBHInventors: Sebastian VOGT, Klaus-Dieter KÜHN
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Publication number: 20120164312Abstract: A method for coating at least regions of a medical implant includes providing a medical implant having a surface to be coated, and immersing the surface of the medical implant into a liquid including at least one pharmaceutically active substance, whereby the liquid is transferred to the surface of the medical implant due to the immersing. The method also includes pulling the surface of the medical implant out of the liquid, whereby part of the liquid remains adhering to the surface of the medical implant.Type: ApplicationFiled: December 21, 2011Publication date: June 28, 2012Applicant: HERAEUS MEDICAL GMBHInventors: Sebastian VOGT, Klaus-Dieter KÜHN
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Patent number: 8092824Abstract: An antibiotic coating of implants is described, which is characterized in that the coating comprises at least one saturated, organic, hydrophobic, low molecular matrix former whose melting point is in the temperature range of 45° C. to 100° C., in which a low molecular, hydrophobic additive is dissolved and that an antibiotic/antibiotics is/are suspended in the mixture of matrix former and additive and/or in which an antibiotic/antibiotics miscible with a mixture of matrix former and additive is/are dissolved.Type: GrantFiled: January 19, 2006Date of Patent: January 10, 2012Assignee: Heraeus Kulzer GmbHInventors: Klaus-Dieter Kühn, Sebastian Vogt, Matthias Schnabelrauch
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Patent number: 8075907Abstract: The invention relates to a PMMA revision bone cement having powder and liquid component, in which the powder component contains two or more granular antibiotics whose grain size distribution is equal in that the main screening fraction each of the individual antibiotics is in the same grain size range, in particular in the range of 100-250 ?m or 150-250 ?m.Type: GrantFiled: January 22, 2008Date of Patent: December 13, 2011Assignee: Heraeus Kulzer GmbHInventors: Klaus-Dieter Kühn, Sebastian Vogt, Hubert Büchner
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Publication number: 20110287064Abstract: An implant is provided having an antibiotic coating that is inexpensive and easy to manufacture. The antibiotic coating adheres well and in stable manner to the surface of the implant, can be degraded by the body without forming toxic products, prevents the crystallization of the antibiotics in the coating, and ensures a high immediate locally-effective antibiotic concentration at the implant site. A coating solution useful for making the implant and a method for the manufacture of the implant are also described.Type: ApplicationFiled: May 18, 2011Publication date: November 24, 2011Applicant: HERAEUS MEDICAL GMBHInventors: Sebastian VOGT, Hubert BÜCHNER, Klaus-Dieter KÜHN
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Patent number: 7923019Abstract: Antibiotic/s containing bone substitute material is described which is characterized in that it is composed of a compacted mixture of granules of calcium sulfate dihydrate, calcium carbonate and at least one representative of the aminoglycoside antibiotics, lincosamide antibiotics, glycopeptide antibiotics, macrolide antibiotics, ketolide antibiotics, the nitroimidazoles, the fluorochinolone antibiotics and the oxazolidinone antibiotics, the steroid antibiotics, the antiseptic agents and the fungicidal/fungistatic antibiotics which are partly or entirely sheathed with a layer of glycerol tripalmitate and/or glycerol tristearate and/or glycerol trilaurate and/or 1-hexadecyl alcohol which connects the granules with each other.Type: GrantFiled: December 5, 2005Date of Patent: April 12, 2011Assignee: Heraeus Kulzer GmbHInventors: Klaus-Dieter Kühn, Sebastian Vogt
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Publication number: 20110015673Abstract: A surgical suture material with an antimicrobial surface is described, the surface exhibiting a coating containing a) at least one fatty acid, b) octenidine dichloride and/or dequalinium chloride and c) optionally oligomeric lactic acid esters. In addition, a process for coating surgical suture material is described which is characterized by the fact that the thread material is wetted with a homogeneous methanolic solution of octenidine dichloride and/or dequalinium chloride and subsequently the methanol is evaporated, a coating forming on the thread surface.Type: ApplicationFiled: September 24, 2010Publication date: January 20, 2011Applicant: HERAEUS KULZER GMBHInventors: Sebastian VOGT, Klaus-Dieter Kühn, Hubert Büchner
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Patent number: 7858109Abstract: Form bodies, which can be rotationally-symmetrical or irregularly-shaped, consist of at least one member of the group of the antibiotic salts, gentamicin myristate, gentamicin palmitate, gentamicin stearate, tobramycin myristate, tobramycin palmitate, tobramycin stearate, amikacin myristate, amikacin palmitate, amikacin stearate, vancomycin palmitate, vancomycin stearate, ramoplanin palmitate, ramoplanin stearate, levofloxacin palmitate, levofloxacin stearate, ofloxacin palmitate, ofloxacin stearate, moxifloxacin palmitate, moxifloxacin stearate, clindamycin palmitate, and clindamycin stearate. A medical device for implantation, in which the form bodies are arranged on a biodegradable filament at a distance of 1 mm to 25 mm as well as a method for the manufacture of the medical device and the use of the form bodies or the medical device to treat chronic osteomyelitis are described.Type: GrantFiled: February 15, 2007Date of Patent: December 28, 2010Assignee: Heraeus Kulzer GmbHInventors: Klaus-Dieter Kühn, Sebastian Vogt
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Patent number: 7655706Abstract: A polymethylmethacrylate bone cement with a liquid monomer component and a solid component contains in the monomer liquid, for example, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, for example, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer for the dye or dye mixture. The solubilizer preferably is liquid or pasty at room temperature. The monomer liquid is translucent at room temperature. Preferably, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, preferably, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer that is liquid or pasty at room temperature are homogeneously dissolved in the polymethacrylate or polymethylacrylate of the powder component.Type: GrantFiled: June 6, 2006Date of Patent: February 2, 2010Assignee: Heraeus Kulzer GmhHInventors: Klaus-Dieter Kühn, Sebastian Vogt