Abstract: The invention is directed to the provision of solid pharmaceutical compositions (and methods for their preparation) containing nifidipine crystals with a specific surface area of 1.0 to 4.0 m.sup.2 /g., in admixture with a solid diluent. The said compositions overcome the deficiencies of prior art compositions containing nifidipine, which is known to have effect as a coronary vasodilator.

Abstract: A sprayable liquid formulation comprising, per 100 ml of the formulation,(a) 0.2 to 5 grams of a dihydropyridine of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl with 1 to 10 carbon atoms optionally substituted by alkoxy with 1 to 3 carbon atoms, trifluoromethyl, halogen or N-methyl-N-benzylamino,R.sup.3 is alkyl with 1 to 4 carbon atoms, cyano or hydroxymethyl, andX is a nitro group, one or two chlorine groups or the ring member .dbd.N--O--N.dbd.,(b) 10 to 40 grams of polyethylene glycol with an average molecular weight of 200 to 600,(c) 25 to 60 grams of ethyl alcohol, and(d) 3 to 15 grams of polyvinylpyrrolidine with an average molecular weight of 12000 to 30000.

Abstract: In the treatment of cardiovascular and coronary disorders by administering to a patent suffering therefrom a solid preparation comprising nifedipine, the improvement which comprises administering such nifedipine in the form of a solid two-phase medicament formulation comprising a nifedipine coprecipitate, in which the nifedipine is present in a non-crystalline form, and crystalline nifedipine, whereby the nifedipine rapidly enters the blood stream in a relatively high concentration which is maintained for a relatively long time.

Abstract: A rapidly absorbable liquid formulation of a dihydropyridine comprising, by weight, about 0.5 to 10 parts of a dihydropyridine of the formula ##STR1## in which R.sub.1 is C.sub.1 -C.sub.4 -alkyl, optionally substituted by C.sub.2 -C.sub.3 -alkoxy,R.sub.2 is C.sub.1 -C.sub.10 -alkyl, optionally substituted by C.sub.1 -C.sub.3 -alkoxy, trifluoromethyl or N-methyl-N-benzylamino,R.sub.3 is C.sub.1 -C.sub.4 -alkyl, cyano or hydroxymethyl, andX is 2- or 3-nitro, 2,3-dichloro or 2,3.dbd.N--O--N.dbd.,20 to 60 parts of a solubilizing agent and 80 to 40 parts of a diluent.