Patents by Inventor Klaus G. Stunkel

Klaus G. Stunkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5510365
    Abstract: The invention relates to the use of 1-thiocarbamoyl-5-hydroxypyrazoles of the general formula ##STR1## in which the substituents denote the radicals mentioned in the description, as pharmaceutical agents for combating septic shock and the consequences thereof.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: April 23, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Wachtler, Lutz Heuer, Michael Sperzel, Klaus G. Stunkel
  • Patent number: 5070190
    Abstract: The invention relates to new N-glycosylamides of the general formula I ##STR1## in which R.sup.1 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,R.sup.2 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,A represents --CO-- or represents a group ##STR2## in which R.sup.3 represents hydrogen, C.sub.1 -C.sub.7 alkyl, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-methylthioethyl, 3-aminopropyl, 2-ureidopropyl, 3-guanidylpropyl, 4-aminobutyl, carboxymethyl, carbamoylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, andn represents 0 to 10,and which are substituted in the sugar residue with an amino acid residue, as well as process for their preparation and their use as medicaments.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: December 3, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Oswald Lockhoff, John Goossens, Helmut Brunner, Michael Sperzel, Klaus G. Stunkel
  • Patent number: 4855283
    Abstract: Compounds of the formula ##STR1## in which R.sup.1 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms,X represents --CH.sub.2 --, --O-- or --NH--,R.sup.2 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms,R.sup.3, R.sup.4 and R.sup.5, independently of one another, denotes hydrogen or acyl--CO--R.sup.6, R.sup.6 being an alkyl radical having up to 10 carbon atoms,R.sup.7 denotes hydrogen, C.sub.1 -C.sub.7 -alkyl-, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-(methylthio)-ethyl, 3-aminopropyl, 3-ureidopropyl, 3-guanidyl-propyl, 4-aminobutyl, carboxymethyl, carbamylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, andR.sup.8 represents hydrogen or methyl, andR.sup.9 represents hydrogen, acetyl, benzoyl, trichloroacetyl, trifluoroacetyl, methoxycarbonyl, t-butyloxycarbonyl or benzyloxycarbonyl andR.sup.7 and R.sup.8 together can denote --CH.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: August 8, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Oswald Lockhoff, Yutaka Hayauchi, Peter Stadler, Klaus G. Stunkel, Gert Streissle, Arnold Paessens, Volker Klimetzek, Hans-Joachim Zeiler, Karl G. Metzger, Hein-Peter Kroll, Helmut Brunner, Klaus Schaller
  • Patent number: 4737488
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, an optionally substituted aromatic hydrocarbon radical, an aralkyl radical or an optionally substituted aliphatic hydrocarbon radical having up to 45 C atoms,R.sup.2 is an optionally substituted aromatic hydrocarbon radical, an aralkyl radical or an optionally substituted aliphatic hydrocarbon radical having 5-50 C atoms,X is O, S, NH or NR, R being an alkyl radical having up to 20 C atoms, andZ is a glycosyl radical bonded via the anomeric carbon atom,or pharmaceutically acceptable salts thereof stimulate the immune system.
    Type: Grant
    Filed: November 29, 1984
    Date of Patent: April 12, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Oswald Lockhoff, Bernd-Wieland Kruger, Peter Stadler, Karl G. Metzger, Hans-Georg Opitz, Klaus Schaller, Klaus G. Stunkel, Hans-Joachim Zeiler
  • Patent number: 4737521
    Abstract: A method of stimulating the immune response of a patient which comprises administering to a patient in need thereof an immunostimulating effective amount of 8,8'-[carbonylbis]imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene) carbonylimino]]bis-1,3,5-naphthalenetrisulphonic acid hexasodium salt.
    Type: Grant
    Filed: May 27, 1986
    Date of Patent: April 12, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus G. Stunkel, Rudi Grutzmann
  • Patent number: 4716152
    Abstract: Compounds of the formula ##STR1## in which X is hydrogen or the radical CH.sub.2 OR.sup.5,R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each independently is hydrogen or the radical ##STR2## Y is oxygen, sulphur, NH or CH.sub.2, and R.sup.1 and R.sup.6 each independently is an optionally substituted hydrocarbon radical having up to 50 carbon atoms, with the proviso that at least one of the radicals R.sup.1 and/or R.sup.6 contains between 9 to 50 carbon atoms,some of which are known, stimulate the immune system's response and antibody production.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: December 29, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernd-Wieland Kruger, Oswald Lockhoff, Karl G. Metzger, Hans-Georg Opitz, Klaus Schaller, Klaus G. Stunkel, Hans-Joachim Zeiler
  • Patent number: 4699899
    Abstract: Novel compounds of the formula ##STR1## in which X is hydrogen or --CH.sub.2 --OR.sup.5,Z represents OR.sup.4, NH.sub.2 or ##STR2## R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each independently is hydrogen or ##STR3## at least one of R.sup.2, R.sup.3, R.sup.4 and R.sup.5 being ##STR4## Y and W each independently is oxygen, sulphur, NH or CH.sub.2, and R.sup.1, R.sup.6, R.sup.7 and R.sup.8 each independently is an optionally substituted hydrocarbon radical with up to 50 C atoms,stimulate the immune system.
    Type: Grant
    Filed: February 21, 1986
    Date of Patent: October 13, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernd-Wieland Kruger, Yutaka Hayauchi, Oswald Lockhoff, Peter Stadler, Karl G. Metzger, Klaus G. Stunkel, Hans-Joachim Zeiler
  • Patent number: 4659603
    Abstract: 1-Cyclopropylquinolone-3-carboxylic acids of the formula ##STR1## in which R.sup.1 is hydrogen, methyl, ethyl or .beta.-hydroxyethyl, andR.sup.2 is hydrogen, chlorine or fluorineor salts thereof stimulate the immune system, especially in conjunction with an antigen.
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: April 21, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Grohe, Volker Klimetzek, Karl G. Metzger, Klaus G. Stunkel, Hans-Joachim Zeiler
  • Patent number: 4574122
    Abstract: Compounds of the formula ##STR1## in which X is hydrogen or the radical --CH.sub.2 OR.sup.5,three of R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each independently is hydrogen or ##STR2## and the fourth is ##STR3## Z each independently is oxygen, sulphur, NH or CH.sub.2, and R.sup.1, R.sup.6 and R.sup.7 each independently is an optionally substituted hydrocarbon radical having up to 50 carbon atoms,stimulate the immune system's response and antibody production.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: March 4, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernd-Wieland Kruger, Oswald Lockhoff, Peter Stadler, Karl G. Metzger, Hans-Georg Opitz, Klaus G. Stunkel, Hans-Joachim Zeiler