Patents by Inventor Klaus GRAUMANN

Klaus GRAUMANN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Long-term storage of non-glycosylated recombinant human G-CSF
    Patent number: 9387233
    Abstract: The present invention provides a method for stable long-term storage of non-glycosylated recombinant human Granulocyte-Colony Stimulating Factor (G-CSF), wherein an aqueous acetate or glutamate buffered G-CSF composition containing the non-glycosylated recombinant human G-CSF and sorbital is cooled to a temperature of ?15° C. or below to obtain a frozen G-CSF composition, which frozen composition is then stored in the frozen state and then increased in temperature to a temperature within the range of from 2° C. to 8° C. for a period of time adjusted to allow the composition to thaw and to obtain a liquid composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: July 12, 2016
    Assignee: Sandoz AG
    Inventors: Klaus Graumann, Helmut Lerch, Thomas Lauber
  • Long-Term Storage of Non-Glycosylated Recombinant Human G-CSF
    Publication number: 20140294756
    Abstract: The present invention provides a method for stable long-term storage of non-glycosylated recombinant human G-CSF, wherein an aqueous acetate or glutamate buffered G-CSF composition containing the non-glycosylated recombinant human G-CSF and sorbital is cooled to a temperature of ?15° C. or below to obtain a frozen G-CSF composition, which frozen composition is then stored in the frozen state and then increased in temperature to a temperature within the range of from 2° C. to 8° C. for a period of time adjusted to allow the composition to thaw and to obtain a liquid composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Applicant: SANDOZ AG
    Inventors: Klaus GRAUMANN, Helmut LERCH, Thomas LAUBER
  • Long-term storage of non-glycosylated recombinant human G-CSF
    Patent number: 8784794
    Abstract: The present invention provides a method for stable long-term storage of non-glycosylated recombinant human Granulocyte-Colony Stimulating Factor (“G-CSF”), wherein an aqueous acetate or glutamate buffered G-CSF composition containing the non-glycosylated recombinant human G-CSF and sorbital is cooled to a temperature of ?15° C. or below to obtain a frozen G-CSF composition, which frozen composition is then stored in the frozen state and then increased in temperature to a temperature within the range of from 2° C. to 8° C. for a period of time adjusted to allow the composition to thaw and to obtain a liquid composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: July 22, 2014
    Assignee: Sandoz AG
    Inventors: Klaus Graumann, Helmut Lerch, Thomas Lauber
  • Long-Term Storage of Non-Glycosylated Recombinant Human G-CSF
    Publication number: 20130164253
    Abstract: The present invention provides a method for stable long-term storage of non-glycosylated recombinant human G-CSF, wherein an aqueous acetate or glutamate buffered G-CSF composition containing the non-glycosylated recombinant human G-CSF and sorbital is cooled to a temperature of ?15° C. or below to obtain a frozen G-CSF composition, which frozen composition is then stored in the frozen state and then increased in temperature to a temperature within the range of from 2° C. to 8° C. for a period of time adjusted to allow the composition to thaw and to obtain a liquid composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
    Type: Application
    Filed: June 22, 2011
    Publication date: June 27, 2013
    Applicant: SANDOZ AG
    Inventors: Klaus Graumann, Helmut Lerch, Thomas Lauber
  • Long-term storage of non-glycosylated recombinant Human G-CSF
    Patent number: 8449873
    Abstract: The present invention provides a method for stable long-term storage of non-glycosylated recombinant human G-CSF, wherein an aqueous acetate or glutamate buffered G-CSF composition containing non-glycosylated recombinant human G-CSF and sorbitol is cooled to a temperature of ?15° C. or below to obtain a frozen G-CSF coFmposition, which frozen composition is then stored in the frozen state. The temperature of the frozen G-CSF composition is later increased to a temperature within the range of from 2° C. to 8° C. for a time selected to allow the G-CSF composition to thaw and to obtain a liquid G-CSF composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: May 28, 2013
    Assignee: Sandoz AG
    Inventors: Klaus Graumann, Helmut Lerch, Thomas Lauber
  • Long-Term Storage of Non-Glycosylated Recombinant Human G-CSF
    Publication number: 20120042613
    Abstract: The present invention provides a method for stable long-term storage of non-glycosylated recombinant human G-CSF, wherein an aqueous acetate or glutamate buffered G-CSF composition containing non-glycosylated recombinant human G-CSF and sorbitol is cooled to a temperature of ?15° C. or below to obtain a frozen G-CSF composition, which frozen composition is then stored in the frozen state. The temperature of the frozen G-CSF composition is later increased to a temperature within the range of from 2° C. to 8° C. for a time selected to allow the G-CSF composition to thaw and to obtain a liquid G-CSF composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
    Type: Application
    Filed: June 22, 2011
    Publication date: February 23, 2012
    Applicant: SANDOZ AG
    Inventors: Klaus GRAUMANN, Helmut LERCH, Thomas LAUBER