Patents by Inventor Klaus Hochleitner
Klaus Hochleitner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11073519Abstract: In a lateral flow test (LFT) device, the liquid conduit element 20 is formed from a substrate 21, 22 or 24 having at least two layers, including a first layer 21b, 22b or 24b not exceeding 75 ?m in thickness formed from a porous material for wicking liquid, and a second layer 21a,22a or 24a of additional thickness formed from a generally non-porous polymer material acting as backing layer. The layered arrangement is incorporated into an LFT device to reduce sample volume requirements.Type: GrantFiled: March 17, 2015Date of Patent: July 27, 2021Assignee: Global Life Sciences Solutions Germany GmbHInventors: Alexander Schenk, Klaus Hochleitner, Suzana Kiel, Marcel Thieme, Wei Sun
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Patent number: 10870086Abstract: Disclosed is a method and apparatus for manufacturing a continuous web of polymeric membrane and for continuous downstream processing of said web. The apparatus (10) comprises: a casting station (20) for casting the continuous web (M); a carrier (24) for carrying the web downstream; a membrane drier (30) downstream of the carrier, for drying the web; and a brushing station (40) downstream of the drier for brushing the web. Said drier is located immediately downstream of the carrier, and upstream of said brushing station. The apparatus (10) further includes an additional drying station (50) downstream of the brushing station (40). Brushing after drying retains more surfactant in the membrane which is useful for certain applications. In addition, initial drying eliminates virtually all solvents from the membrane, but leaves some non-solvent (e.g. water) within it, which in turn fixes the surfactant on the nitrocellulose fibers, which improves significantly the consistency and reproducibility of the membrane.Type: GrantFiled: March 24, 2016Date of Patent: December 22, 2020Assignee: Global Life Sciences Solutions Germany GmbHInventors: Marcel Thieme, Klaus Hochleitner, Suzana Kiel, Alexander Schenk, Wolfgang Thamm, Daniela Katarzynski, Georg Peter Danisch
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Patent number: 10683496Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.Type: GrantFiled: May 22, 2018Date of Patent: June 16, 2020Assignee: General Electric CompanyInventors: Lin Chen, Bing Zhang, Klaus Hochleitner, Rong Hou, Yanju Wang
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Publication number: 20180265860Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.Type: ApplicationFiled: May 22, 2018Publication date: September 20, 2018Inventors: Lin Chen, Bing Zhang, Klaus Hochleitner, Rong Hou, Yanju Wang
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Patent number: 10000751Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.Type: GrantFiled: August 8, 2016Date of Patent: June 19, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Lin Chen, Bing Zhang, Klaus Hochleitner, Rong Hou, Yanju Wang
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Publication number: 20180104655Abstract: Disclosed is a method and apparatus for manufacturing a continuous web of polymeric membrane and for continuous downstream processing of said web. The apparatus (10) comprises: a casting station (20) for casting the continuous web (M); a carrier (24) for carrying the web downstream; a membrane drier (30) downstream of the carrier, for drying the web; and a brushing station (40) downstream of the drier for brushing the web. Said drier is located immediately downstream of the carrier, and upstream of said brushing station. The apparatus (10) further includes an additional drying station (50) downstream of the brushing station (40). Brushing after drying retains more surfactant in the membrane which is useful for certain applications. In addition, initial drying eliminates virtually all solvents from the membrane, but leaves some non-solvent (e.g. water) within it, which in turn fixes the surfactant on the nitrocellulose fibers, which improves significantly the consistency and reproducibility of the membrane.Type: ApplicationFiled: March 24, 2016Publication date: April 19, 2018Inventors: Marcel Thieme, Klaus Hochleitner, Suzana Kiel, Alexander Schenk, Wolfgang Thamm, Daniela Katarzynski, Georg Peter Danisch
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Patent number: 9707523Abstract: A membrane filter 26 is disclosed comprising cellulous material 23 allowing the transition of fluid therethrough, and, in a substantially dry state, said membrane comprising also a salt of deoxycholic acid. Optionally, the air side of the membrane (the side facing away from the screen or belt used to manufacture the membrane) faces the sample fluid during use of the membrane. A method of manufacture of the membrane material is disclosed also, employing deoxycholic acid as a surfactant, to improve the recovery rate of the membrane filter in use.Type: GrantFiled: February 22, 2013Date of Patent: July 18, 2017Assignee: Whatman GmbHInventors: Klaus Hochleitner, Suzana Kiel
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Publication number: 20170115287Abstract: In a lateral flow test (LFT) device, the liquid conduit element 20 is formed from a substrate 21, 22 or 24 having at least two layers, including a first layer 21b, 22b or 24b not exceeding 75 ?m in thickness formed from a porous material for wicking liquid, and a second layer 21a,22a or 24a of additional thickness formed from a generally non-porous polymer material acting as backing layer. The layered arrangement is incorporated into an LFT device to reduce sample volume requirements.Type: ApplicationFiled: March 17, 2015Publication date: April 27, 2017Inventors: Alexander Schenk, Klaus Hochleitner, Suzana Kiel, Marcel Thieme, Wei Sun
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Publication number: 20160340669Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.Type: ApplicationFiled: August 8, 2016Publication date: November 24, 2016Inventors: Lin Chen, BING Zhang, Klaus Hochleitner, Rong Hou, Yanju Wang
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Patent number: 9441220Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.Type: GrantFiled: December 20, 2012Date of Patent: September 13, 2016Assignee: General Electric CompanyInventors: Lin Chen, Bing Shang, Klaus Hochleitner, Rong Hou, Yanju Wang
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Publication number: 20150377872Abstract: The invention discloses a reduced thickness membrane matrix for carrying liquids consisting of a cellulosic material with a thickness of between 10 and 50 ?m and a pore size between 0.1 ?m and 20 ?m for use with diagnostic tests such as lateral flow tests, thereby reducing the amount of test reagents required.Type: ApplicationFiled: February 3, 2014Publication date: December 31, 2015Inventors: Klaus HOCHLEITNER, Suzana KIEL, Alexander SCHENK, Wei SUN
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Publication number: 20150299693Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.Type: ApplicationFiled: December 20, 2012Publication date: October 22, 2015Applicant: GENERAL ELECTRIC COMPANYInventors: LIN CHEN, BING SHANG, KLAUS HOCHLEITNER, RONG HOU, YANJU WANG
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Publication number: 20150027945Abstract: A membrane filter 26 is disclosed comprising cellulous material 23 allowing the transition of fluid therethrough, and, in a substantially dry state, said membrane comprising also a salt of deoxycholic acid. Optionally, the air side of the membrane (the side facing away from the screen or belt used to manufacture the membrane) faces the sample fluid during use of the membrane. A method of manufacture of the membrane material is disclosed also, employing deoxycholic acid as a surfactant, to improve the recovery rate of the membrane filter in use.Type: ApplicationFiled: February 22, 2013Publication date: January 29, 2015Applicant: WHATMAN GMBHInventors: Klaus Hochleitner, Suzana Kiel