Patents by Inventor Klaus Huthmacher

Klaus Huthmacher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleotide sequences which code for the metY gene
    Publication number: 20050064551
    Abstract: The present invention relates to isolated polynucleotides which encode proteins with O-acetylhomoserine sulfhydrylase, vectors and cells containing the polynucleotides as well as methods of preparing L-amino acids.
    Type: Application
    Filed: May 5, 2004
    Publication date: March 24, 2005
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Method for synthesis of 2,2,6-trimethylcyclohexan-1-one
    Publication number: 20050027142
    Abstract: The present invention relates to a method for synthesis of 2,2,6-trimethylcyclohexan-1-one (TMCH) by partial reduction of 2,6,6-trimethyl-2-cyclohexen-1,4-dione (ketoisophorone, KIP), the reaction being carried out in the gas phase in the presence of oxide catalysts.
    Type: Application
    Filed: July 30, 2004
    Publication date: February 3, 2005
    Applicant: DEGUSSA AG
    Inventors: Susanne Kleinfeld, Achim Fischer, Frank Wilz, Christoph Weckbecker, Klaus Huthmacher
  • Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes
    Patent number: 6822085
    Abstract: Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: November 23, 2004
    Assignee: Degussa AG
    Inventors: Mike Farwick, Klaus Huthmacher, Natalie Schischka, Brigitte Bathe, Walter Pfefferle, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Nucleotide sequences encoding o-succinylhomoserine sulfhydrylase
    Patent number: 6815196
    Abstract: The present invention relates to isolated polynucleotides from Corynebacterium glutamicum encoding proteins of the transcription activator (MetR) and O-succinylhomoserine sulfhydrylase (MetZ). The invention also relates to producing L-amino acids, particularly methionine, in coryneform cells having attenuated metR and metZ genes.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: November 9, 2004
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Nucleotide sequences which code for the metY gene
    Patent number: 6812016
    Abstract: The present invention relates to isolated polynucleotides which encode proteins with O-acetylhomoserine sulfhydrylase, vectors and cells containing the polynucleotides as well as methods of preparing L-amino acids.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: November 2, 2004
    Assignee: Degussa AG
    Inventors: Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Process for the preparation of alpha-amino acids by hydrolysis of hydantoins at elevated pressure and elevated temperature
    Patent number: 6797827
    Abstract: A process for the preparation of &agr;-amino acids by hydrolysis of hydantoins in the presence of water and at least one metallic oxide under conditions such that all the starting materials are completely dissolved in the water as a result of high pressure and high temperature and only one further phase is present in the reactor in addition to the metallic oxide phase.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: September 28, 2004
    Assignee: Degussa AG
    Inventors: Martin Körfer, Dieter Buss, Horst Weigel, Christoph Weckbecker, Hans Joachim Hasselbach, Klaus Huthmacher
  • Nucleotide sequences which code for the RodA protein
    Patent number: 6777206
    Abstract: The invention provides nucleotide sequences from Coryneform bacteria which code for the RodA protein and a process for the fermentative preparation of amino acids using bacteria in which the rodA gene is enhanced.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: August 17, 2004
    Assignee: Degussa AG
    Inventors: Mike Farwick, Klaus Huthmacher, Walter Pfefferle, Brigitte Bathe
  • Nucleotide sequences which code for the sahH gene
    Patent number: 6759224
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria, in which at least the sahH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: July 6, 2004
    Assignee: Degussa AG
    Inventors: Mike Farwick, Klaus Huthmacher, Jennifer Brehme, Walter Pfefferle, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Process for the preparation of alpha-amino acids by hydrolysis of hydantoins at elevated pressure and elevated temperature
    Publication number: 20040039228
    Abstract: A process for the preparation of &agr;-amino acids by hydrolysis of hydantoins in the presence of water and at least one metallic oxide under conditions such that all the starting materials are completely dissolved in the water as a result of high pressure and high temperature and only one further phase is present in the reactor in addition to the metallic oxide phase.
    Type: Application
    Filed: July 30, 2003
    Publication date: February 26, 2004
    Inventors: Martin Korfer, Dieter Buss, Horst Weigel, Christoph Weckbecker, Hans Joachim Hasselbach, Klaus Huthmacher
  • Cloning and expression of D-amino acid oxidase from arthrobacter protophormiae
    Publication number: 20040009561
    Abstract: The present invention is directed to a nucleotide sequence encoding D-amino oxidase (D-AAO, EC 1.4.3.3) from Arthrobacter protophormiae. This may be inserted into an expression and used to transform a microbial host. The transformed microbial hosts ecomically produce D-AAO which may be used to oxidize D-amino acids.
    Type: Application
    Filed: June 18, 2003
    Publication date: January 15, 2004
    Applicant: Degussa AG
    Inventors: Werner Hummel, Birgit Geueke, Andrea Weckbecker, Klaus Huthmacher, Christoph Weckbecker
  • Process for the production of canthaxanthin
    Publication number: 20040010164
    Abstract: The present invention relates to a process for the production of canthaxanthin by oxidation of beta-carotene or carotinoids derived therefrom which have conjugated double bonds.
    Type: Application
    Filed: June 6, 2003
    Publication date: January 15, 2004
    Applicant: Degussa AG
    Inventors: Frank Dubner, Jurgen Bilz, Christoph Weckbecker, Klaus Huthmacher
  • Novel nucleotide sequences coding for the citE gene
    Publication number: 20030157666
    Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group
    Type: Application
    Filed: February 28, 2003
    Publication date: August 21, 2003
    Applicant: Degussa AG
    Inventors: Mike Farwick, Klaus Huthmacher, Achim Marx, Brigitte Bathe, Walter Pfefferle
  • Process for the preparation of unsaturated ketones
    Patent number: 6586635
    Abstract: A process for the preparation of &bgr;,&ggr;,&dgr;-unsaturated ketones and/or &agr;,&bgr;,&ggr;,&dgr;-unsaturated ketones by the reaction of an unsaturated alcohol with an enol ether or mixture of enol ethers, with formation of ketals as a by-product, at temperatures of from 50° C. to 200° C., in the presence of an acid catalyst, whereby one or all of the reagents is/are heated to the reaction temperature of from 50° C. to 200° C. before the acid catalyst is added.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: July 1, 2003
    Assignee: Degussa AG
    Inventors: Nongyuan Shi, Bernd Drapal, Steffen Krill, Markus Julino, Klaus Huthmacher
  • Novel nucleotide sequences coding the citE gene
    Publication number: 20030113879
    Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group
    Type: Application
    Filed: June 6, 2001
    Publication date: June 19, 2003
    Inventors: Mike Farwick, Klaus Huthmacher, Achim Marx, Brigitte Bathe, Walter Pfefferle
  • Nucleotide sequences which code for the sahH gene
    Publication number: 20030100080
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of
    Type: Application
    Filed: August 2, 2001
    Publication date: May 29, 2003
    Applicant: DEGUSSA AG
    Inventors: Mike Farwick, Klaus Huthmacher, Jennifer Brehme, Walter Pfefferle, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Nucleotide sequences which code for the metD gene
    Publication number: 20030092026
    Abstract: The invention relates to polynucleotides comprising polynucleotide sequences corresponding to the metD gene and parts thereof that encode polypeptide sequences and parts thereof possessing varying degrees of MetD transcription regulator activity, methods for preparation of L-amino acids, and methods of screening and amplifying polynucleotides encoding polypeptide sequences which comprise varying degrees of MetD transcription regulator activity. Further, the invention relates to animal food additives based on fermentation liquor and containing L-methionine, and to the preparation of such additive.
    Type: Application
    Filed: May 30, 2002
    Publication date: May 15, 2003
    Applicant: DEGUSSA AG
    Inventors: Daniel Rey, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Brigitte Bathe, Klaus Huthmacher, Walter Pfefferle
  • Process for the preparation of L-amino acids by using coryneform bacteria
    Publication number: 20030092137
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process includes fermenting the coryneform bacteria producing the desired L-amino acid, in which at least the gene coding for 6-phosphofructokinase and/or the gene coding for 1-phosphofructokinase are/is attenuated, enriching the desired L-amino acid in the medium or in the cells of the bacteria, and isolating the L-amino acid. Optionally bacteria are employed in which, in addition, further genes of the biosynthetic pathway of the desired L-amino acid are enhanced, or bacteria are employed in which the metabolic pathways that diminish the formation of the desired L-amino acid are at least partly switched off.
    Type: Application
    Filed: March 18, 2002
    Publication date: May 15, 2003
    Inventors: Mike Farwick, Brigitte Bathe, Jennifer Brehme, Klaus Huthmacher
  • Hydrolysis of acylamino acids
    Patent number: 6552222
    Abstract: A process for the preparation of racemic amino acids, characterized in that an acylamino acid of the formula R1—CH(NH—CO—R2)COOH wherein R1 is hydrogen, a linear, branched or cyclic alkyl that has from 1 to 7 carbon atoms and that may contain substituents such as a hydroxyl, alkyloxy or alkylthio group; and R2 is a hydrogen atom or an alkyl having from 1 to 3 carbon atoms; is heated in the presence of water, in a pressure-resistant vessel, to a temperature in the range from 110° C. to 220° C. and is hydrolyzed.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: April 22, 2003
    Assignee: Degussa AG
    Inventors: Klaus Huthmacher, Christoph Weckbecker, Horst Weigel
  • Process for the preparation of &bgr;-isophorone epoxide
    Patent number: 6482964
    Abstract: Process for the selective preparation of &bgr;-isophorone epoxide by epoxidation of &bgr;-isophorone with organic percarboxylic acids at a water content of less than 5 wt. %.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: November 19, 2002
    Assignee: Degussa AG
    Inventors: Steffen Krill, Klaus Huthmacher, Alexander Möller
  • Process for the preparation of unsaturated ketones
    Publication number: 20020169342
    Abstract: A process for the preparation of &bgr;,&ggr;,&dgr;-unsaturated ketones and/or &agr;,&bgr;,&ggr;,&dgr;-unsaturated ketones by the reaction of an unsaturated alcohol with an enol ether or mixture of enol ethers, with formation of ketals as a by-product, at temperatures of from 50° C. to 200° C., in the presence of an acid catalyst, whereby one or all of the reagents is/are heated to the reaction temperature of from 50° C. to 200° C. before the acid catalyst is added.
    Type: Application
    Filed: April 26, 2002
    Publication date: November 14, 2002
    Applicant: DEGUSSA AG
    Inventors: Nongyuan Shi, Bernd Drapal, Steffen Krill, Markus Julino, Klaus Huthmacher