Abstract: A central locking system with a two-door control for motor vehicles, in which certain locking operations are precluded in dependance on the position of the key of a starter switch of the driving engine. In order to prevent an unitentional locking of the vehicle doors under certain operating conditions, means are provided according to the present invention which enable a locking actuation of the central locking system exclusively by the interior actuating element of the driver door on the steering column side when the key is in the starter whereas only a mechanical locking of the individual front door on the passenger side is possible by way of the interior actuating element of this passenger door.