Patents by Inventor Klaus Melchers

Klaus Melchers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Screening kit and process for determining action of substances inhibiting the P-type ATPase activity of Helicobacter pylori
    Patent number: 5981184
    Abstract: A screening-model is disclosed for determining the inhibiting effect of substances on the P-type ATP-ase activity of Helicobacter. The screening model in question comprises: (a) a recombinant organism consisting of host cells transformed with at least one P-type ATP-ase gene which can be controlled via a promoter; (b) an inductor for gene activation of the P-type ATP-ase; (c) cations which inhibit the metabolic activity of the recombinant organism only in the presence of Helicobacter P-type ATP-ase; and (d) a measurement device for determining the metabolic activity of the recombinant organism.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: November 9, 1999
    Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventor: Klaus Melchers
  • Process for identification of substances modulating ureI dependent mechanisms of Helicobacter pylori metabolism
    Patent number: 5942409
    Abstract: The present invention provides a screening process for the identification of anti-helicobactericidal substances modulating ureI dependent mechanisms of gastric Helicobacter metabolism. Gastric Helicobacter cells are treated with a substance to be tested for modulating ureI dependent mechanisms of gastric Helicobacter metabolism and gastric Helicobacter acid resistance or sensitivity to urea is determined.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: August 24, 1999
    Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventors: George Sachs, Klaus Melchers
  • Synthetic peptide analogs of lung surface protein SP-C
    Patent number: 5874406
    Abstract: Polypeptide analogs of human the human lung surfactant protein, SP-C, are provided. The polypeptides have the following structure: ##STR1## wherein A is H or Phe, B is Phe or Trp, and C is Ile, Leu, or Ser. They exhibit surfactant activity and are useful in the treatment of respiratory distress syndromes in premature infants and adults.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: February 23, 1999
    Assignee: BYK Gulden Lomberg Chemische Fabrik GmbH
    Inventors: Klaus Peter Schafer, Klaus Melchers