Abstract: A method, computer program product, and computer system are provided. A machine hypervisor builds and enqueue a zeroize adjunct processor (AP) domain (ZAPD) common command request message to a target AP domain queue. Machine firmware validates the enqueued common command request message on the target AP domain queue. The machine firmware converts the ZAPD command request to the mode-specific form of the domain zeroize request. A command request message is executed at an AP crypto adapter of the target AP domain. Executing includes zeroizing a storage area of the AP crypto adapter. The execution results are returned to the machine firmware. The machine firmware converts the crypto card mode's ZAPD command reply message into the common ZAPD command reply message. The final execution results including the converted common ZAPD command reply message are returned to the machine hypervisor.