Abstract: Systems and methods for improved NMR signal detection are described. The system receives NMR signal data produced by a sample over time in response to an excitation pulse and selects a predefined system function for application to the NMR signal data for systematic variation of signal properties The system function has a different influence on NMR signal components than on noise components of the sampled signal and has a variation parameter to control the systematic variation. A plurality of variation parameter values is provided with differing values to influence broad NMR signals as well as weak NMR signals. The system generates for each variation parameter value a corresponding intermediate data set by applying the system function with the respective variation parameter value to the NMR signal data. Further, from each intermediate data set, a respective base value centered spectrum is generated in the frequency-domain.

Abstract: Systems and methods for improved NMR signal detection are described. The system receives NMR signal data produced by a sample over time in response to an excitation pulse and selects a predefined system function for application to the NMR signal data for systematic variation of signal properties The system function has a different influence on NMR signal components than on noise components of the sampled signal and has a variation parameter to control the systematic variation. A plurality of variation parameter values is provided with differing values to influence broad NMR signals as well as weak NMR signals. The system generates for each variation parameter value a corresponding intermediate data set by applying the system function with the respective variation parameter value to the NMR signal data. Further, from each intermediate data set, a respective base value centered spectrum is generated in the frequency-domain.

Abstract: A NMR method to verify the presence of organic molecular compounds consisting of repetitive occurring individual structures is presented. The method comprises the steps of assigning structure codes to the selected compounds, in accordance with the respective starting compounds used, measuring multi-dimensional NMR spectra from at least some of the compounds, uniquely assigning signal groups of NMR spectra to the individual structures, checking the NMR spectra of the compounds for the presence of all assigned signal groups, and characterizing a particular compound as being TRUE if the check of its particular combination of structures yields the result that the signal groups of structures contained in its total code had been observed. The method permits rapid and accurate verification of the presence of compounds having repetitive structures such as those produced in combinatorial chemistry.

Abstract: A NMR method to verify the presence of organic molecular compounds consisting of repetitive occurring individual structures is presented. The method comprises the steps of assigning structure codes to the selected compounds, in accordance with the respective starting compounds used, measuring multi-dimensional NMR spectra from at least some of the compounds, uniquely assigning signal groups of NMR spectra to the individual structures, checking the NMR spectra of the compounds for the presence of all assigned signal groups, and characterizing a particular compound as being TRUE if the check of its particular combination of structures yields the result that the signal groups of structures contained in its total code had been observed. The method permits rapid and accurate verification of the presence of compounds having repetitive structures such as those produced in combinatorial chemistry.

Abstract: A NMR method to verify the presence of organic molecular compounds consisting of repetitive occurring substructures is presented. The method comprises the steps of assigning sub-structure codes to the selected compounds, in accordance with the respective starting compounds used, measuring multi-dimensional NMR spectra from at least some of the compounds, uniquely assigning signal groups of NMR spectra to the individual sub-structures, checking the NMR spectra of the compounds for the presence of all assigned signal groups, and characterizing a particular compound as being TRUE if the check of its particular combination of substructures yields the result that the signal groups of substructures contained in its total code had been observed. The method permits rapid and accurate verification of the presence of compounds having repetitive substructures.