Abstract: An extrusion-based additive manufacturing process including the step of selectively depositing a molten thermoplastic material (P) on a film or sheet made from or containing a polymer blend obtained by melt blending a mixture made from or containing: (A) 60% to 98.8% by weight of a polyolefin; (B) 0.1% to 30% by weight of a compatibilizer; (C) 0.05% to 20% by weight of an amino resin; and (D) 0% to 5% by weight of an additive, wherein the amounts of (A), (B), (C) and (D) are based on the total weight of (A)+(B)+(C)+(D).

Abstract: A suction gripping device for picking up a plurality of substrates which are flat and flexible includes: a base body, which defines a plane; at least one gas suction vacuum module which is arranged on the base body and has at least one gas suction opening configured for withdrawing gas by suction and for generating a first vacuum so as to suction a respective one of the plurality of substrates against the suction gripping device; and at least one gas ejection vacuum module which is arranged on the base body and has a gas ejection opening configured for ejecting gas and for generating a second vacuum so as to suction the respective one of the plurality of substrates against the suction gripping device.

Abstract: The invention provides novel biparatopic LRP5/LRP6 cross-reactive binding polypeptides, and more specifically novel biparatopic LRP5/LRP6 cross-reactive immunoglobulin single variable domain constructs which can inhibit Wnt signaling pathways. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as cancer.

Abstract: A system, template, and method of managing virtual control units in an industrial automation facility are provided. The industrial automation facility includes machines. The method includes generating templates including deployment criteria for the virtual control units. Each of the virtual control units is capable of controlling at least one of the machines. The virtual control units are mapped to one or more compute nodes based on the deployment criteria. The virtual control units are instantiated on the mapped compute nodes when the controlled machines are in operation. The method includes validating that the instantiation of the virtual control units is in accordance with the templates using an attestation that confirms determined deployment parameters after deployment of the virtual control units. The machines perform the industrial process, according to control commands received from at least one of the virtual control units, when the virtual control units are validly instantiated.

Abstract: Systems are provided for isolation of a protein, such as immunoglobulin G (IgG), from plasma, where the protein is initially fractioned by salt precipitation, followed by successive ion exchange steps in which the protein appears in unbound, flow-through fractions of the ion exchange steps. Some embodiments employ successive anion exchange steps. Other embodiments employ an anion exchange step followed by application of flow-through of the anion exchange step to a cation exchange step, with the protein collected in flow-through fractions from the cation exchange step. IgG is collected at high yield (typically about 75% or greater) and high purity. Avoidance of binding and elution from chromatography media simplifies processing and scale up without sacrificing IgG quality or yield.

Abstract: The present invention relates to novel binding molecules. The invention specifically relates to binding molecules that bind to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-3 (CDH3). The invention also relates to nucleic acids encoding such binding molecules; to methods for preparing such binding molecules; to host cells expressing or capable of expressing such binding molecules; to compositions comprising such binding molecules; and to uses of such binding molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: A device for determining a condition of a composite component, including: an input interface for receiving measurement data with information on a condition of the composite component; an analysis unit for determining a condition of the composite component based on the measurement data; and an output interface for transmitting the determined condition; wherein the measurement data includes an electrical charge transfer and/or electrical voltage, which can be generated by the composite component through mechanical excitation of the composite component; and the analysis unit is designed and configured to determine the condition of the composite component on the basis of the electrical charge separation and/or electrical voltage. The present invention further relates to a corresponding system and method.

Abstract: The disclosure relates to a method for operating a cooling chamber in a strand guide device and the strand guide device 10 as such. The strand guide device serves to deflect a freshly cast strand, typically made of metal, into the horizontal. During the deflection, the cast strand passes through a cooling chamber 1 inside the strand guide device 2, in which it is sprayed with a coolant 33, with the formation of steam 5. The steam forms at least a steam-air mixture 5? with sucked-in secondary air, which is sucked out of the cooling chamber by a suction device 20. In particular, in order to reduce the pollutant content of the sucked-in and sucked-off steam-air mixture 5? and its emission into the environment, the present invention provides for pollutants, primarily dust, located in the steam-air mixture 5? by a separator 6, 6? to deplete.

Abstract: Methods are provided for isolation of immunoglobulin G (IgG) from plasma, where IgG is initially fractioned by salt precipitation, followed by successive ion exchange steps in which IgG appears in unbound, flow-through fractions of the ion exchange steps. Some embodiments employ successive anion exchange steps. Other embodiments employ an anion exchange step followed by application of flow-through of the anion exchange step to a cation exchange step, with IgG collected in flow-through fractions from the cation exchange step. IgG is collected at high yield (typically about 75% or greater) and high purity. Avoidance of binding and elution from chromatography media simplifies processing and scale up without sacrificing IgG quality or yield.

Abstract: A method for operating a blast furnace for producing of pig iron, comprising the steps of including heating a stream of hydrocarbon gas and a stream of steam in a first heater to provide a heated stream of hydrocarbon gas and steam, feeding and partially reforming the heated stream of hydrocarbon gas and steam in a pre-reformer to provide a stream of partially reformed syngas, heating a first stream of blast furnace gas from the blast furnace and the stream of partially reformed syngas in a second heater, before or after their mixing together, to provide a heated carbon feed stream, reforming the heated carbon feed stream in a secondary reformer to provide a second stream of syngas, and feeding said second stream of syngas to the shaft of the blast furnace.

Abstract: Various embodiments of the teachings herein include an attestation component configured to attest a cloud-based execution environment. The cloud-based execution environment comprises at least one application instance and a project plan assigned to the at least one application instance. The attestation component may include: a determination component configured to determine at least one piece of trustworthiness information indicating a trustworthiness of the cloud-based execution environment and of the at least one application instance; and a linking component configured to establish a link between the trustworthiness information and the project plan.

Abstract: A coating module to coat a substrate with a coating composition includes a coating device to apply a layer of coating composition on the outer surface of the substrate, and a flexible film including a distal portion designed to be in contact with the coated substrate.

Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: A drill bit for chiselling rock includes an impact face at an insertion end of the drill bit, a hollow shank, where a delivery passage is defined within the hollow shank, and a drill head, where the drill head has a cutting edge, an intake opening, and an intake passage and where the intake passage connects the intake opening to the delivery passage. A first portion of the intake passage which adjoins the intake opening has a first inclination with respect to a drill bit axis, a second portion of the intake passage which adjoins the hollow shank has a second inclination with respect to the drill bit axis, and the second inclination is greater than the first inclination.

Abstract: A method for preparing granules. A slurry containing solid API powder particles dispersed in a liquid is prepared. The slurry is fed to a granulator and mixed with a dry base powder within the granulator in order to produce a slurry/base powder mixture. The slurry/base powder mixture produced within the granulator is dried in order to obtain granules containing the solid API particles and the base powder.

Abstract: A coating module for variable speed ribbon coating, the coating module including a ribbon including an inner face and an outer face; a conveyor system including a support element holding and transporting the ribbon on its inner face; a squeeze ink roller arranged in contact with the outer face of the ribbon; the squeeze ink roller including an outer layer made of elastic material; a reservoir assembly designed to hold ink thereon and to feed the squeeze ink roller with the ink, and a pressure controller including an active element for pressing the ribbon between the squeeze ink roller and the support roller along a coating zone.

Abstract: A shaft furnace, in particular a blast furnace, comprises includes an outer metal shell; a plurality of tuyeres arranged to inject hot blast into the shaft furnace; and means for injecting process gas in the shaft stack area, where the injector has a nozzle body with a peripheral wall extending along a longitudinal axis from a front portion, with at least one injection hole, to an opposite rear portion connected to a base member, where the nozzle body includes an inner gas channel for guiding process gas from an inlet port in the base member to the injection holes(s), nozzle body being mounted through an aperture in the metal shell in such a way that the front region with injection hole(s) is located on the inner side of the metal shell, whereas the rear portion is outside of the metal shell, and the base member includes a peripheral mounting portion configured for connecting the injector in a gas tight manner to a mounting unit surrounding the aperture in the metal shell.

Abstract: A device for identifying anomalies in an industrial system for implementing a production process for a product in which the industrial system includes a plurality of sensors for measuring process variables of the production process includes an anomaly detector having at least one trained artificial intelligence, wherein the artificial intelligence is configured and trained to detect and/or predict anomalies in the production process based on a plurality of measured data from the sensors, where the anomaly detector outputs anomaly information upon detecting and/or predicting an anomaly, where in this case anomalies may be detected and predicted at the same time in multiple different performance indicators of the production process, and where the performance indicators each relate to the entire production process for the production of the product.

Abstract: A venous valve prosthesis for transporting a flow of body fluid in a vessel in a predetermined direction includes includes a hollow-cylindrical support structure. A skirt is connected to the support structure and forms a closed, circumferential jacket of the support structure. The prosthesis also includes a valve leaflet arrangement with a first valve leaflet and a second valve leaflet, each being connected to the skirt. A downstream edge of the first valve leaflet and a downstream edge of the second valve leaflet are opposite to each other and configured in such a manner that in a first state of the valve leaflet arrangement they form an opening for blood to flow through in the predetermined direction and in a second state of the valve leaflet arrangement the opening is closed and to prevent a backflow of blood in a direction opposite to the predetermined direction. A ratio of the inner diameter of the support structure to its length in the predetermined direction is at most 1.

Abstract: A weapon system having a breechblock, wherein the breechblock can be mechanically connected to a drive of the weapon system. The weapon system comprises means which are designed in such a way that a mechanical separation occurs between the breechblock and the breechblock drive with the recoil of the recoiling masses of the weapon system. With the forward motion of the recoiling masses, the mechanical connection between the breechblock drive and the breechblock is re-formed.