Abstract: A device produces and fills containers, in which at least one hose of plasticized plastic material emerging from an extrusion head (2) can be extruded into an opened mold. A filling device (14) can be used to at least introduce the filling material into the relevant container by filling mandrels (12), which, at least during operation, extend through the extrusion head (2) along at least one row of passages (40). The extrusion head (2) has a cuboid shell (20, 22). The overall height (H) of the extrusion head (2), viewed in parallel to the orientation of the relevant filling mandrel (12), is smaller than the length (L) of the extrusion head (2), viewed along the pertinent row of passages (40).

Abstract: Methods and systems are provided for an oil gallery of a piston. In one example, a system for a piston comprising an internal oil gallery. The internal oil gallery comprises one or more of a funnel shaped inlet, a funnel shaped outlet, and a plurality of tongues extending along a circumference of the internal oil gallery.

Abstract: A method for determining in a sample, by mass spectrometry, the presence, absence, or amount of one or more analytes is described herein. The run time is less than six minutes. The method includes subjecting the sample to an ionization source under conditions suitable to produce one or more ions detectable by mass spectrometry from each of the one or more analytes, wherein the one or more analytes are derivatized prior to ionization; measuring, in a single injection, by mass spectrometry, the amount of the one or more ions from each of the one or more analytes; and using the measured amount of the one or more ions to determine the amount of each of the one or more analytes in the sample.

Abstract: A fairing for an aircraft is disclosed in which the fairing comprises a first fairing portion configured to be fixedly attached to a first structural component and having a first edge; a second fairing portion configured to be fixedly attached to a second structural component and having a second edge, wherein the first edge and the second edge define an interface configured to enable relative movement between the first fairing portion and the second fairing portion.

Abstract: A method for producing ultra-thin glass sheets is provided that results in glass sheets with high edge strength. The method includes: hot forming a continuous glass ribbon with a glass thickness from molten glass; annealing the glass ribbon with an annealing rate chosen based on the glass thickness; producing a laser beam focus area that is longer than the glass thickness; introducing filamentary defects into the glass ribbon using the laser beam so that the filamentary defects extend from one face to the opposite face and are spaced apart from one another along the breaking lines to produce transverse breaking lines and longitudinal breaking lines with margins each comprising a thickened bead; separating the beads along the longitudinal breaking lines and separating glass sheets by severing along the transverse breaking lines.

Abstract: The invention provides novel LRP5-binding polypeptides, and more specifically novel LRP5-binding immunoglobulin single variable domain constructs which can inhibit Wnt signaling pathways. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as cancer.

Abstract: A process for preparing an aromatic polyamine mixture including 4,4?-methylenedi(phenylamine) and higher homologues of MDA is provided. The process includes steps of (i) reaction of aniline with formaldehyde by means of an acid catalyst to form a crude product mixture (I), (ii) neutralization of the crude product mixture (I) and removal of the salts formed; (iii) isolation of aniline; (iv) distillation of the resulting crude product mixture so as to separate off (iv-1) a mixture (II) of MDA isomers (II-1) containing from 8 to 20% by weight of 4,4?-methylenedi(phenylamine) and not more than 0.3% by weight of secondary components (II-2) and (iv-2) a low boiler mixture of at least 55% by weight of secondary components (II-2) and MDA isomers (II-1); and (v) recirculation of the mixture (II).

Abstract: A communication system for current-modulated transmission of data via a current loop—into which a master device and at least one slave device are looped. The at least one slave device has a switching means that is actuable by an evaluation and control unit and that is configured to short a current loop in the closed state, wherein the evaluation and control unit is configured to temporarily close and then reopen the switching means during a system configuration detection phase. An evaluation and control unit of the master device—is configured to detect when the at least one slave device is looped into the current loop.

Abstract: A driver cab for an industrial truck comprises a driver canopy supported by four pillars, wherein two of the four pillars are configured as entry way pillars and two of the four pillars are configured as end wall pillars. A side wall extends between each of the entry way pillars and the end wall pillars, an end wall extends between the end wall pillars, and a boarding area extends between the entry way pillars. Each of the end wall pillars comprises a tubular profile and at least one of the entry way pillars comprises a corner profile which comprises two limbs arranged at an angle with respect to one another.

Abstract: A measuring device for determining the filling level of a filling material in a container is simple and inexpensive to produce and allows largely continuous determination of the filling level of an unknown filling material in a container. The measuring device has at least three measuring sensors in mutually spaced relationship in a heightwise direction. A read-out device having at least three measuring inputs for reading out the measuring sensor signals is provided. Each measuring sensor signal depends on material properties of a filling material arranged adjacent to the respective measuring sensor. A calibration device which effects calculation of the filling level detected by a measuring sensor positioned neither right at the top nor right at the bottom in the heightwise direction, on the basis of the measuring sensor signal of the further upwardly arranged measuring sensor and/or the further downwardly arranged measuring sensor.

Abstract: The present disclosure relates to photoactivable protecting groups containing a diarylsulfide chromophore, a method for the synthesis thereof and their use as photoactivable protecting groups using maskless photolithography based array synthesis.

Abstract: An active wheel suspension element has a ball screw drive having a screw drive with a threaded spindle and a spindle nut which is mounted in a housing via an axial bearing. The axial bearing is formed as a rolling bearing, whose rolling element rolls directly on the spindle nut.

Abstract: Disclosed is a cosmetic product comprising a metal can which comprises a metal container (A) which has a rotary thread (A?) and contains a cosmetic preparation as well as a lid (D) having a thread (D?) and being of the same metal as the container. The lid can be screwed onto/unscrewed from the container by means of threads (D?) and (A?) via rotational movement. The cosmetic preparation comprises an emulsion of one or more hydrophilic phases and one or more lipophilic phases. The one or more lipophilic phases comprise at least one lipid having a spreading coefficient at 25° C. of no more than 700 mm2/10 minutes, at least one lipid having a dropping point of >30° C., and at least one monovalent and/or polyvalent alcohol in a total amount of at least 3 wt. %.

Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: A device for producing a 3D-printed active substance-releasing system with active substance depots, such that a radiation source in operation causes a polymerisation of a layer of the base material on the construction platform and that an inkjet printhead incorporates an active substance mixture, which has at least one active substance, into the base material in a locationally selective manner. A trough is provided, in which a base material and a construction platform are arranged, and polymerising selected regions of a layer of the base material on the construction platform and introducing, by means of an inkjet printing method, an active substance mixture, which has at least one active substance, into the base material and/or polymerised base material in a locationally selective manner in order to thereby create active ingredient depots in the active ingredient-releasing system.

Abstract: A method for preparing granules a slurry containing solid API powder particles dispersed in a liquid is prepared. The slurry is fed to a granulator and mixed with a dry base powder within the granulator in order to produce a slurry/base powder mixture. The slurry/base powder mixture produced within the granulator is dried in order to obtain granules containing the solid API particles and the base powder.

Abstract: Drug products in the form of modified release formulations comprising the drug substance (?)-(3aR,4S,7aR)-4-Hydroxy-4m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester (AFQ056), as well as processes for making such drug products are provided. The drug products are useful in treating patients with Parkinson's disease and exhibiting L-dopa induced dyskinesia.

Abstract: A permanently colored object having a silicone surface which is produced by means of the following steps: a) mixing coloring substances with a still cross-linkable silicone in order to form an application mixture, b) swelling the silicone surface by means of a solvent, c) applying the application mixture to the silicone surface, and d) performing the cross-linking of the silicone of the application mixture, which silicone penetrates the silicone surface.

Abstract: A control method for a bore-chiseling portable power tool for machining a substrate by a drill bit includes superimposing a periodic striking on the drill bit at an impact rate and a rotating of the tool holder at a rotational speed in a rotational direction, identifying a material of the substrate being machined by the drill bit by a sensor, adjusting the rotational speed and/or the rotational direction to a first rotational speed and a first rotational direction when the identified material is an iron-based material, and adjusting the rotational speed and/or the rotational direction to a second rotational speed and a second rotational direction when the identified material is a mineral material. The first rotational speed is less than the second rotational speed and the first rotational direction is counter-clockwise and the second rotational direction is clockwise.

Abstract: A method for transmitting electrical energy between a charging station and a motor vehicle which is electrically coupled to the charging station, in which the motor vehicle is coupled to the charging station via an electrical charging connection cable that includes at least two electrical lines, where a communication connection is produced between the charging station and the motor vehicle, the transmission of the electrical energy through the charging station is adjusted based on energy storage data transmitted from the motor vehicle to the charging station (10), and where the communication connection is produced at least partially over the at least two electrical lines of the electrical charging connection cable via at least one charging-station-side and at least one motor-vehicle-side communication adapter.