Abstract: A method and an apparatus (100) for electrostatically discharging a primary packaging container (102) made of plastics are disclosed. The method comprises moving a primary packaging container (102) to be electrostatically discharged so as to pass at least one electrode (104, 106, 108), applying an alternating voltage to the electrode (104, 106, 108) so as to generate ionized air in a vicinity of the electrode (104, 106, 108), and rotating the primary packaging container (102) in the vicinity of the electrode (104, 106, 108) so as to be contacted by the ionized air.

Abstract: In a working cylinder, with a cylinder casing, in the cylinder interior of which is mounted a driving piston capable of linear movement under fluidic pressurization, wherein the cylinder casing is mounted between two cylinder covers closing the cylinder interior, wherein the cylinder covers each have a central section and an outer frame section, with at least four mounting areas and encompassing the central section, wherein there is formed between the frame section and the central section an annular space, in which are provided reinforcing struts aligned radially and each extending towards an assigned mounting area, outer surfaces of each reinforcing strut diverge away from the assigned mounting area towards the central section.

Abstract: A method and an apparatus (100) for electrostatically discharging a primary packaging container (102) made of plastics are disclosed. The method comprises moving a primary packaging container (102) to be electrostatically discharged so as to pass at least one electrode (104, 106, 108), applying an alternating voltage to the electrode (104, 106, 108) so as to generate ionized air in a vicinity of the electrode (104, 106, 108), and rotating the primary packaging container (102) in the vicinity of the electrode (104, 106, 108) so as to be contacted by the ionized air.

Abstract: In a working cylinder, with a cylinder casing, in the cylinder interior of which is mounted a driving piston capable of linear movement under fluidic pressurisation, wherein the cylinder casing is mounted between two cylinder covers closing the cylinder interior, wherein the cylinder covers each have a central section and an outer frame section, with at least four mounting areas and encompassing the central section, wherein there is formed between the frame section and the central section an annular space, in which are provided reinforcing struts aligned radially and each extending towards an assigned mounting area, outer surfaces of each reinforcing strut diverge away from the assigned mounting area towards the central section.

Abstract: The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.

Abstract: The current invention comprises a method for the regeneration of a cation exchange chromatography column.

Abstract: A magnetic core, such as for an interphase transformer, made of a nanocrystalline alloy, which consists of Fe100-a-b-c-d-x-y-zCuaNbbMcTdSixByZz and up to 1 at. % of impurities, whereby M is one or more of the elements Mo, Ta or Zr; T is one or more of the elements V, Cr, Co or Ni; and Z is one or more of the elements C, P or Ge, and 0 at. %?a<1.5 at. %, 0 at. %?b<4 at. %, 0 at. %?c<4 at. %, 0 at. %?d<5 at. %, 12 at. %<x<18 at. %, 5 at. %<y<12 at. %, and 0 at. %?z<2 at. %, the core having a saturation magnetostriction of <2 ppm and a permeability between 100 and 1,500, wherein the alloy has been exposed to a heat treatment at a temperature between 450 and 750° C. under a tensile stress between 30 and 500 MPa.

Abstract: The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.

Abstract: The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.

Abstract: The current invention comprises a method for the regeneration of a cation exchange chromatography column.

Abstract: The current invention comprises a method for the regeneration of a cation exchange chromatography column.

Abstract: The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.

Abstract: The current invention comprises a method for the regeneration of a cation exchange chromatography column.

Abstract: A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of about 10 to 50 amino acids and a second peptide of a length of about 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said inclusion bodies; and (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of about 10 to 50 amino acids and which is a fragment cleaved from said fusion peptide. Inclusion bodies of the peptides are disclosed.

Abstract: A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of about 10 to 50 amino acids and a second peptide of a length of about 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said inclusion bodies; and (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of about 10 to 50 amino acids and which is a fragment cleaved from said fusion peptide. Inclusion bodies of the peptides are disclosed.

Abstract: A process is provided for producing an antifusogenic peptide by producing a fusion peptide of from about 14 amino acids up to 70 amino acids in a prokaryotic host cell under conditions in which inclusion bodies are formed. The antifusogenic peptide recovered from the inclusion bodies is a fragment cleaved from the fusion peptide which comprises an antifusogenic peptide.

Abstract: A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of about 10 to 50 amino acids and a second peptide of a length of about 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said inclusion bodies; and (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of about 10 to 50 amino acids and which is a fragment cleaved from said fusion peptide. Inclusion bodies of the peptides are disclosed.

Abstract: In a screw drive, in particular a ball screw drive, a double nut, formed of a pair of individual nuts, is tightened on a threaded spindle and the individual nuts are secured together against relative rotation by a locking member. The locking member is secured within a radially extending recess formed in and bridging the individual nuts. The locking member can be inserted with a certain amount of play into the recess or borehole and then secured within the recess by a cement or similar material so that it cannot be displaced. Various types of locking members can be used, such as locking bolts or threaded bolts. When the locking member is connected into the recess or ball it prevents any rotation of the individual nuts relative to one another.

Abstract: A bearing assembly operatively interposed between a shaft and a housing having said shaft axially movably mounted therein for torque transmission therebetween includes a ball bushing inserted into a bushing receiving bore in the housing and guided through ball rings in ball races, with at least one of said ball rings being a load-transmitting ring including a load-transmitting ball ring section which rests radially inwardly against the shaft and radially outwardly against an external support surface defined by the ball bushing. The load bearing ball ring section of the at least one ball ring engages a race groove in the shaft on the shaft side of the ball ring and it engages a race groove of a bearing plate mounted in the ball bushing on the ball bushing side of the ball ring in a manner to transmit torque therebetween.