Abstract: A method of processing magnetic resonance data of a sample under investigation includes the steps of provision of the MR data being collected with an MRI scanner apparatus, and machine learning based data analysis of the MR data by supplying the MR data to an artificial neural network being trained with predetermined training data, wherein at least one image parameter of the sample and additionally at least one uncertainty quantification measure representing a prediction error of the at least one image parameter are provided by output elements of the neural network. Furthermore, a magnetic resonance imaging (MRI) scanner apparatus being adapted for employing the method of processing MR data is described.

Abstract: A method of magnetic resonance tomography includes arranging an object in a static magnetic field, subjecting it to radiofrequency (RF) pulses and magnetic field gradients for creating spatial encoding of magnetic resonance signals, acquiring the signals with at least two RF receive coils, each with a self-resonance frequency and a spatially restricted sensitivity profile, and reconstructing an object image. Spatial encoding of the signals by the gradients and the profiles is utilized, wherein the profile of at least one of the coils is subjected to a temporal sensitivity profile modulation while acquiring the signal. The self-resonance frequency of the at least one coil is set within a predetermined receive bandwidth of a constant resonance frequency value during the modulation. The reconstructing further utilizes the modulation for obtaining additional spatial information to the spatial encoding of the signals by the gradients. Furthermore, an MRI device is described.

Abstract: A method of processing magnetic resonance data of a sample under investigation includes the steps of provision of the MR data being collected with an MRI scanner apparatus, and machine learning based data analysis of the MR data by supplying the MR data to an artificial neural network being trained with predetermined training data, wherein at least one image parameter of the sample and additionally at least one uncertainty quantification measure representing a prediction error of the at least one image parameter are provided by output elements of the neural network. Furthermore, a magnetic resonance imaging (MRI) scanner apparatus being adapted for employing the method of processing MR data is described.

Abstract: A method of processing magnetic resonance (MR) data of a sample under investigation, includes the steps of providing the MR data being collected with an MRI scanner apparatus, and subjecting the MR data to a multi-parameter nonlinear regression procedure being based on a non-linear MR model and employing a set of input parameters, wherein the regression procedure results in creating a parameter map of model parameters of the sample, wherein the input parameters (initial values and possibly boundaries) of the regression procedure are estimated by a machine learning based estimation procedure applied to the MR data. The machine learning based estimation procedure preferably includes at least one of at least one neural network and a support vector machine. Furthermore, an MRI scanner apparatus is described.

Abstract: A method of magnetic resonance (MR) tomography imaging an object (1) comprises arranging the object in a static magnetic field, subjecting the object to at least one radiofrequency pulse and magnetic field gradients for creating spatially encoded MR signals, acquiring MR signals, and reconstructing an object image utilizing the spatial encoding of the MR signals, wherein, during the acquiring step, the MR signals are subjected to a locally specific frequency modulation by means of at least one spatially restricted, time-varying magnetic modulation field with a component parallel to the static magnetic field, and the step of reconstructing the object image further utilizes the frequency modulation for obtaining spatial information from the spatially encoded MR signals.

Abstract: A method of magnetic resonance tomography includes arranging an object in a static magnetic field, subjecting it to radiofrequency (RF) pulses and magnetic field gradients for creating spatial encoding of magnetic resonance signals, acquiring the signals with at least two RF receive coils, each with a self-resonance frequency and a spatially restricted sensitivity profile, and reconstructing an object image. Spatial encoding of the signals by the gradients and the profiles is utilized, wherein the profile of at least one of the coils is subjected to a temporal sensitivity profile modulation while acquiring the signal. The self-resonance frequency of the at least one coil is set within a predetermined receive bandwidth of a constant resonance frequency value during the modulation. The reconstructing further utilizes the modulation for obtaining additional spatial information to the spatial encoding of the signals by the gradients. Furthermore, an MRI device is described.

Abstract: A method of processing magnetic resonance (MR) data of a sample under investigation, includes the steps of providing the MR data being collected with an MRI scanner apparatus, and subjecting the MR data to a multi-parameter nonlinear regression procedure being based on a non-linear MR model and employing a set of input parameters, wherein the regression procedure results in creating a parameter map of model parameters of the sample, wherein the input parameters (initial values and possibly boundaries) of the regression procedure are estimated by a machine learning based estimation procedure applied to the MR data. The machine learning based estimation procedure preferably includes at least one of at least one neural network and a support vector machine. Furthermore, an MRI scanner apparatus is described.

Abstract: The invention relates to an MRI apparatus for magnetic resonance imaging of a subject of investigation, comprising: a coil arrangement (1) for transmitting an excitation signal into the subject and for receiving a response signal from the subject; a high-power radio-frequency amplifier (4) for generating the excitation signal; and a low-noise amplifier (LNA) for amplifying the response signal. The invention provides a transmit/receive switch (5) which is alternatively operable in a transmit mode or in a receive mode. In the transmit mode, the transmit/receive switch (5) transmits the excitation signal to the coil arrangement (1) and protects the low-noise amplifier (LNA) from the outgoing excitation signal. In the receive mode, the transmit/receive switch (5) routes the in coming response signal to the low-noise amplifier (LNA).

Abstract: A method for correcting Bo fluctuation-induced ghosting artifacts in long-TE gradient-echo scan images, comprising the steps of: acquiring an image (u); determining phase offsets (?); and applying the phase offsets (?) to the image (u); such that an entropy of the spatial intensity variations in the corrected image (u) decreases.

Abstract: The invention relates to an MRI apparatus for magnetic resonance imaging of a subject of investigation, comprising: a coil arrangement (1) for transmitting an excitation signal into the subject and for receiving a response signal from the subject; a high-power radio-frequency amplifier (4) for generating the excitation signal; and a low-noise amplifier (LNA) for amplifying the response signal. The invention provides a transmit/receive switch (5) which is alternatively operable in a transmit mode or in a receive mode. In the transmit mode, the transmit/receive switch (5) transmits the excitation signal to the coil arrangement (1) and protects the low-noise amplifier (LNA) from the outgoing excitation signal. In the receive mode, the transmit/receive switch (5) routes the in coming response signal to the low-noise amplifier (LNA).

Abstract: A system and method for metabolic MR imaging of a hyperpolarized agent includes exciting a single metabolic species of a hyperpolarized agent injected into a subject of interest. MR signals are acquired from the excited single metabolic species and an image is reconstructed from the acquired MR signals.

Abstract: Disclosed is a magnetic resonance method for the quantification of molecular diffusion. The method uses a diffusion-weighted (dw) double echo steady state sequence (DESS). In particular, the method allows direct quantification of molecular diffusion from two steady state scans with differing diffusion weighting such as one with diffusion-weighting and preferably one without diffusion weighting. Such a quantification of molecular diffusion allows for rapid and/or quantitative measurements of physiological and/or functional parameters of living tissue. Quantitative measurements are often a prerequisite for pre-clinical and clinical research as well as for clinical trials in drug research performed at different sites. Especially for the early diagnosis of subtle or diffuse pathological changes, quantitative MR promises to have a very significant impact.

Abstract: A system and method for metabolic MR imaging of a hyperpolarized agent includes exciting a single metabolic species of a hyperpolarized agent injected into a subject of interest. MR signals are acquired from the excited single metabolic species and an image is reconstructed from the acquired MR signals.

Abstract: Apparatus and methods for quantification of transverse relaxation times (T2) using steady-state free precession sequences (generally known as fast imaging sequences) and their sensitivity to a quadratic increase of the RF pulse phase, also known as RF spoiling. Using at least two image acquisitions with different partial RF spoiling increments, T2 can be assessed with high precision and with short acquisition times in the limit of large excitation angles being independent on the longitudinal relaxation time (T1) and magnetization transfer effects as compared to other SSFP based quantitative T2 methods. This invention is not restricted to any kind of target and may be applied in 3D as well as in 2D.

Abstract: Disclosed is a magnetic resonance method for the quantification of molecular diffusion. The method uses a diffusion-weighted (dw) double echo steady state sequence (DESS). In particular, the method allows direct quantification of molecular diffusion from two steady state scans with differing diffusion weighting such as one with diffusion-weighting and preferably one without diffusion weighting. Such a quantification of molecular diffusion allows for rapid and/or quantitative measurements of physiological and/or functional parameters of living tissue. Quantitative measurements are often a prerequisite for pre-clinical and clinical research as well as for clinical trials in drug research performed at different sites. Especially for the early diagnosis of subtle or diffuse pathological changes, quantitative MR promises to have a very significant impact.

Abstract: Apparatus and methods for modification of the frequency response profile of steady-state free precession (SSFP) type of magnetic resonance imaging (MRI) sequences. Using alternating dephasing moments within succeeding radiofrequency (RF) excitation pulses, the frequency response function of SSFP sequences can be modified to different shapes such as near triangular or bell shaped. The particular response function as produced by alternating dephasing moments can be used, among others, for functional brain MRI, MR spectroscopy or spatial encoding.

Abstract: Apparatus and methods for quantification of transverse relaxation times (T2) using steady-state free precession sequences (generally known as fast imaging sequences) and their sensitivity to a quadratic increase of the RF pulse phase, also known as RF spoiling. Using at least two image acquisitions with different partial RF spoiling increments, T2 can be assessed with high precision and with short acquisition times in the limit of large excitation angles being independent on the longitudinal relaxation time (T1) and magnetization transfer effects as compared to other SSFP based quantitative T2 methods. This invention is not restricted to any kind of target and may be applied in 3D as well as in 2D.

Abstract: Apparatus and methods for modification of the frequency response profile of steady-state free precession (SSFP) type of magnetic resonance imaging (MRI) sequences. Using alternating dephasing moments within succeeding radiofrequency (RF) excitation pulses, the frequency response function of SSFP sequences can be modified to different shapes such as near triangular or bell shaped. The particular response function as produced by alternating dephasing moments can be used, among others, for functional brain MRI, MR spectroscopy or spatial encoding.

Abstract: A magnetic sensor navigation system is disclosed, which includes: (a) a magnetic sensor array, including one or more magnetic non-Faradaic sensors; (b) a sensor interface operatively connected to receive a signal from each sensor of the array, wherein the sensor interface operates to generate a processed signal from one or more signals received from each sensor of the array; and (c) a processing and control unit connected to receive the processed signal, wherein the processing and control unit operates to calculate a spatial position of the sensor array using the processed signal when the sensor array is placed within a magnetic resonance environment of an MR scanner.

Abstract: Disclosed are methods and apparatuses for generating susceptibility-related contrast images, as induced, e.g., by marker material interventional devices used for passive MR-guided interventions, or by particles or cells loaded with marker materials used for molecular imaging, cell-tracking or cell-labeling. Near a local magnetic field perturber a positive contrast signal emanates from local gradient compensation to form, e.g., a balanced SSFP type of echo, whereas everywhere else echoes are shifted outside of the data acquisition window.