Patents by Inventor Klaus Schiene

Klaus Schiene has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of Pain Associated with Trigeminal Neuralgia
    Publication number: 20120309840
    Abstract: The use of tapentadol for the treatment of pain associated with disorders of the trigeminal nerve, in particular for use in the treatment of pain associated with trigeminal neuralgia.
    Type: Application
    Filed: April 3, 2012
    Publication date: December 6, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Thomas CHRISTOPH, Jean De Vry, Thomas Tzschentke, Petra Bloms-Funke, Klaus Schiene, Michel Hamon
  • Vanilloid Receptor Ligand Compounds, Pharmaceutical Compositions Containing Them, a Method of Producing Them and the Use Thereof to Treat Pain and Various Other Conditions
    Publication number: 20120302602
    Abstract: Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical composition s containing such compounds, a method for producing the compounds, and the use of such compounds to treat pain and various other conditions.
    Type: Application
    Filed: July 25, 2012
    Publication date: November 29, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Derek Saunders, Jeewoo Lee
  • Compounds involving mGluR5 receptor regulation and methods of making the compounds
    Patent number: 8318774
    Abstract: 3-((Thiazol-2-yl)amino)propylproiolamide compounds of the formula I: wherein the variables are as defined herein, are useful to prevent or treat a disease or disorder involving mGluR5 receptor regulation. Also disclosed are pharmaceutical compositions containing the compounds and methods of making the compounds.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: November 27, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Michael Haurand, Klaus Schiene, Sven Kühnert, Melanie Reich
  • Substituted sulfonamide compounds
    Patent number: 8318769
    Abstract: Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment and/or inhibition of pain and other conditions at least partly mediated by the bradykinin 1 receptor.
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: November 27, 2012
    Assignee: Gruenethal GmbH
    Inventors: Stefan Oberboersch, Melanie Reich, Stefan Schunk, Michael Franz-Martin Engels, Ruth Jostock, Tieno Germann, Jean De Vry, Klaus Schiene, Sabine Hees
  • Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands
    Publication number: 20120258946
    Abstract: Substituted phenylureas and phenylamides, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds for preparing pharmaceutical compositions.
    Type: Application
    Filed: November 9, 2011
    Publication date: October 11, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Nils Damann, Sven Frormann, Bernhard Lesch, Derek John Saunders, Jeewoo Lee, Yong-Soo Kim, Myeong-Seop Kim, Hannelore Stockhausen
  • Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety
    Patent number: 8278338
    Abstract: Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines=compounds corresponding to formula (I), wherein the various substituents have the meaning provided in the description, and pharmaceutical formulations containing these compounds and methods for producing these compounds and related pharmaceutical formulation, and to methods for treating or inhibiting pain, depression and/or anxiety states.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: October 2, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Bernd Sundermann, Hagen-Heinrich Hennies, Klaus Schiene, Petra Bloms-Funke, Werner Englberger, Sven Frormann, Derek Saunders
  • Vanilloid receptor ligand compounds, pharmaceutical compositions containing them, a method of producing them and the use thereof to treat pain and various other conditions
    Patent number: 8252816
    Abstract: Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical composition s containing such compounds, a method for producing the compounds, and the use of such compounds to treat pain and various other conditions.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: August 28, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Derek Saunders, Jeewoo Lee
  • Substituted Cyclic Carboxamide and Urea Derivatives as Ligands of the Vanilloid Receptor
    Publication number: 20120046301
    Abstract: Substituted cyclic carboxamide and urea compounds, a process for their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds for the treatment and/or inhibition of pain and other conditions mediated by the vanilloid receptor 1.
    Type: Application
    Filed: August 19, 2011
    Publication date: February 23, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry
  • Axomadol or a Metabolite Thereof for Use in the Treatment of Irritable Bowel Syndrome
    Publication number: 20120022294
    Abstract: The invention relates to axomadol or a metabolite thereof for use in the treatment of irritable bowel syndrome.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 26, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Klaus Schiene, Petra Bloms-Funke, Thomas Christoph, Wolfgang Schroeder
  • Tapentadol for use in the treatment of irritable bowel syndrome
    Publication number: 20120004317
    Abstract: The invention relates to tapentadol for use in the treatment of Irritable Bowel Syndrome
    Type: Application
    Filed: June 29, 2011
    Publication date: January 5, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Klaus SCHIENE, Petra Bloms-Funke, Thomas Christoph, Wolfgang Schroeder
  • Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions
    Patent number: 8084484
    Abstract: Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting pain and various other disorders or conditions.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: December 27, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Derek Saunders, Bernd Sundermann, Jeewoo Lee
  • Substituted nicotinamide compounds and uses thereof
    Patent number: 8084470
    Abstract: Substituted nicotinamide compounds corresponding to formula I a process for their preparation, pharmaceutical compositions containing these compounds, and the use thereof for the treatment or inhibition conditions such as pain, epilepsy, migraine, anxiety states, or urinary incontinence.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: December 27, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Sven Kuehnert, Robert Frank, Dagmar Kaulartz, Wolfgang Schroeder, Gregor Bahrenberg, Klaus Schiene
  • Pharmaceutical Combination
    Publication number: 20110306674
    Abstract: A pharmaceutical combination comprising as components (a) at least one 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol compound, and (b) at least one NMDA-antagonist, a pharmaceutical formulation and a dosage form comprising such a combination, and a method of treating pain, e.g. inflammatory pain or neuropathic pain, in which components (a) and (b) are administered simultaneously or sequentially to a mammal, with component (a) being administered either before or after component (b), and with components (a) or (b) being administered to the mammal either via the same pathway of administration or via different pathways of administration.
    Type: Application
    Filed: June 14, 2011
    Publication date: December 15, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Klaus SCHIENE, Petra Bloms-Funke
  • Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof to Treat Pain and Other Conditions
    Publication number: 20110301156
    Abstract: Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting pain and various other disorders or conditions.
    Type: Application
    Filed: August 16, 2011
    Publication date: December 8, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Derek Saunders, Bernd Sundermann, Jeewoo Lee
  • Substituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain
    Patent number: 8017772
    Abstract: Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: September 13, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Thomas Christoph, Stefan Oberboersch, Klaus Schiene, Gregor Bahrenberg, Robert Frank, Sven Kuehnert, Wolfgang Schroeder
  • Substituted propiolic acid amides and their use for producing drugs
    Patent number: 8008304
    Abstract: The present invention relates to substituted propiolic acid amides, methods for the production thereof, medicaments containing these compounds and the use thereof for producing medicaments.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: August 30, 2011
    Assignee: Grüenthal GmbH
    Inventors: Michael Haurand, Klaus Schiene, Sven Kühnert, Melanie Reich, Saskia Zemolka
  • Method of inhibiting inflammatory pain
    Patent number: 8003701
    Abstract: A method of treating or inhibiting, in particular, pain caused by inflammation in a mammal by administering to the mammal an effective inflammatory pain alleviating amount of a (1RS,3RS,6RS)-6-dimethyl-aminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol compound, preferably in the form of a physiologically acceptable salt, such as the hydrochloride.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: August 23, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Klaus Schiene, Guenther Haase, Babette-Yvonne Koegel, Elmar Friderichs, Ulrich Jahnel
  • Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions
    Publication number: 20110184020
    Abstract: Vanilloid receptor ligand compounds corresponding to formula I: a process for producing such compounds, pharmaceutical compositions containing them, and the use of such compounds to treat pain and various other vanilloid receptor mediated conditions.
    Type: Application
    Filed: March 31, 2011
    Publication date: July 28, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Derek Saunders, Michael Przewosny, Bernd Sundermann, Jeewoo Lee
  • Pharmaceutical Combination Comprising 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-Dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an Antiepileptic
    Publication number: 20110053914
    Abstract: A pharmaceutical combination comprising: (a) at least one 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol component and/or at least one 6-dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol component, and (b) at least one antiepileptic; a pharmaceutical composition comprising said combination, a medicament comprising such a combination, a kit containing the ingredients of such a combination, and a method of treating pain in which components (a) and (b) are administered simultaneously or sequentially, whereby component (a) may be administered before or after component (b), and in which components (a) and (b) are administered either via the same or a different pathway of administration.
    Type: Application
    Filed: August 27, 2010
    Publication date: March 3, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Klaus SCHIENE, Petra Bloms-Funke
  • Substituted imidazo[2,1-b]thiazole compounds and uses thereof
    Patent number: 7893069
    Abstract: Substituted imidazo[2,1-b]thiazole compounds corresponding to formula I, a method for producing them, pharmaceutical compositions containing them, and the use thereof for regularing mGluR5 receptors, or for treating or inhibiting disorders or disease states at least partially mediated by mGluR5 receptor such as pain, anxiety attacks, drug or alcohol dependency, and others.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: February 22, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Sven Kuehnert, Saskia Zemolka, Michael Haurand, Klaus Schiene