Abstract: The present invention relates to targeting peptides and more specifically peptides that target heart and various tumors as well as to their use for targeting. The present invention also provides a composition comprising at least one therapeutic agent and at least one peptide of the invention or, alternatively, a nucleic acid molecule encoding such a peptide as well as its use for the preparation of a drug intended for gene transfer. The present invention also provides an adenoviral vector comprising at least one peptide of the invention exposed at the surface of the viral particle and its use for targeting tumor cells as well as a method for treating or preventing a cancer or a tumor comprising administering said adenoviral vector.

Abstract: The present invention relates to a composition which is intended for transferring at least one therapeutically active substance into the interior of a target cell, characterized in that it comprises a mixture of at least one therapeutically active substance and at least one polar compound which is selected from a specific group of aprotic polar compounds. The therapeutically active substance is preferably a polynucleotide, and the polar compound is DPSO, which improves the ability of the polynucleotide to be transfected into the interior of the cells. The compositions according to the invention can be used as a diagnostic therapeutic, prophylactic or vaccinal medicament for treating the human or animal body by means of gene therapy.

Abstract: The present invention relates to targeting peptides and more specifically peptides that target heart and various tumors as well as to their use for targeting. The present invention also provides a composition comprising at least one therapeutic agent and at least one peptide of the invention or, alternatively, a nucleic acid molecule encoding such a peptide as well as its use for the preparation of a drug intended for gene transfer.