Patents by Inventor Klaus Seuwen

Klaus Seuwen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying a modulator that inhibits the binding between Epstein-Barr virus induced receptor 2 and cholesterol derived ligands
    Patent number: 8497075
    Abstract: The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7,25-dihydroxycholesterol) (“7,25DHC”) and/or cholest-5-ene-3b, 7b-diol (7-hydroxycholesterol) (“7HC”). The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Grant
    Filed: July 12, 2009
    Date of Patent: July 30, 2013
    Assignees: Novartis AG, IRM LLC, Euroscreen SA, The Scripps Research Institute
    Inventors: Birgit Baumgarten, Francois Gessier, Andreas Katopodis, Richard Knochenmuss, Rocco Falchetto, Silvio Roggo, Andreas Sailer, Klaus Seuwen, Carsten Spanka, Juan Zhang, Sebastien Hannedouche, Sophie Noel, Marie-Odile Roy, Yu Chen, Charles Y. Cho, Wei Li, Weijun Shen
  • ORGANIC COMPOUNDS
    Publication number: 20110243923
    Abstract: The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7, 25-dihydroxycholesterol) (“7,25DHC”) and/or cholest-5-ene-3b, 7b-diol (7-hydroxycholesterol) (“7HC”). The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Application
    Filed: July 12, 2009
    Publication date: October 6, 2011
    Inventors: Birgit Baumgarten, Francois Gessier, Andreas Katopodis, Richard Knochenmuss, Rocco Falchetto, Silvio Roggo, Andreas Sailer, Klaus Seuwen, Carsten Spanka, Juan Zhang, Sebastien Hannedouche, Sophie Noel, Marie-Odile Roy, Yu Chen, Charles Y. Cho, Wei Li, Weijun Shen
  • INHIBITION OF GPR4
    Publication number: 20100144835
    Abstract: The present invention relates to the use of a GPR4 inhibitor for the manufacture of a medicament for the inhibition of angiogenesis, for instance for the inhibition of tumour growth in the treatment of cancer. In a preferred embodiment, said inhibitor is a siRNA, preferably double-stranded. In addition, the present invention further encompasses non-human animals wherein the GPR4 has been inactivated, for instance a knock-out mouse lacking GPR4, and the use of said animals as an experimental model for angiogenesis and for screening for compounds modulating angiogenesis.
    Type: Application
    Filed: December 13, 2007
    Publication date: June 10, 2010
    Inventors: Klaus Seuwen, Eric Billy, Thomas Suply, Lorenza Wyder, Janet Dawson King, Marie-Gabrielle Ludwig, Matthias Mueller, Puneeta Nath, Carol Elizabeth Jones
  • NOVEL G-PROTEIN COUPLED RECEPTORS AND DNA SEQUENCES THEREOF
    Publication number: 20070275391
    Abstract: The present invention relates to in particular immune modulatory polypeptides and polynucleotides, recombinant materials and methods for their production. Such polypeptides and polynucleotides are of interest in relation to methods of treatment of diseases whereby immune responses initiated by dendritic cells (DC), monocytes or lymphocytes, play a causal or contributory role.
    Type: Application
    Filed: September 29, 2006
    Publication date: November 29, 2007
    Inventors: Gung-Wei Chirn, Uwe Dengler, Frank Kolbinger, Quicheng Ma, Nanguneri Nirmala, Klaus Seuwen, Gudrun Werner
  • Proton-sensing g-protein coupled receptors and dna sequences thereof
    Publication number: 20070092527
    Abstract: This invention relates to the newly identified utility of certain G protein-coupled receptors (GPCRs), in particular to OGR1, GPR4 and TDAG8 (TDAG8 is also named GPR65) polypeptides, and polynucleotides encoding such GPCR polypeptides, to their use in diagnosis and to methods of identifying compounds that are agonists or antagonists to said GPCRs, and to the production of such polypeptides and polynucleotides.
    Type: Application
    Filed: June 18, 2004
    Publication date: April 26, 2007
    Applicant: NOVARTIS AG
    Inventors: Birgit Baumgarten, Carol Jones, Marie-Gabrielle Ludwig, Georg Martiny-Baron, Klaus Seuwen, Romain Wolf, Lorenza Wyder, Thomas Suply
  • Novel g-protein coupled receptors and dna sequences thereof
    Publication number: 20050107589
    Abstract: The present invention relates to in particular immune modulatory polypeptides and polynucleotides, recombinant materials and methods for their production. Such polypeptides and polynucleotides are of interest in relation to methods of treatment of diseases whereby immune responses initiated by dendritic cells (DC), monocytes or lymphocytes, play a causal or contributory role.
    Type: Application
    Filed: December 16, 2002
    Publication date: May 19, 2005
    Inventors: Gung-Wei Chirn, Uwe Dengler, Frank Kolbinger, Qicheng Ma, Nanguneri Nirmala, Klaus Seuwen, Gudrun Werner
  • G protein coupled receptors and dna sequences thereof
    Publication number: 20040175789
    Abstract: This invention relates to newly identified polypeptides and polynucleotides encoding respiratory chemokine receptor polypeptides and polynucleotides, to their use in diagnosis and in identifying compounds that may be agonists and antagonists that are potentially useful in therapy, and to production of such polypeptides and polynudeotides, belonging to the class of G protein-coupled receptors.
    Type: Application
    Filed: December 22, 2003
    Publication date: September 9, 2004
    Inventors: Umesh Bhatia, Carol Elizabeth Jones, Rochdi Bouhelal, Klaus Seuwen, Laurent Tenaillon