Patents by Inventor Klaus van Leyen

Klaus van Leyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Device and method for imaging shortwave infrared fluorescence
    Patent number: 11579088
    Abstract: Systems and methods for measuring short wave infrared fluorescence and autofluorescent signals are disclosed. In some embodiments, for example, a method may include exposing a portion of tissue that does not include a fluorescent probe to an excitation source of the tissue, wherein at least a portion of the tissue has an autofluorescence spectrum which includes wavelengths greater than 900 nm, and imaging the tissue with a detector that is sensitive to electromagnetic radiation with wavelengths greater than or equal to 900 nm. In certain other embodiments, a system comprises a fluorescent probe including a fluorescent component attached to a carrier, an excitation source, and a detector that detects a tail portion of the fluorescence of the fluorescent component. Methods associated with such a system are also disclosed.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: February 14, 2023
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Moungi G. Bawendi, Oliver Thomas Bruns, Jessica Ann Carr, Klaus van Leyen, Yi Zheng, Marianne Aellen
  • DEVICE AND METHOD FOR DETECTING DISEASE STATES ASSOCIATED WITH LIPOPIGMENTS
    Publication number: 20190307390
    Abstract: Systems and methods for measuring autofluorescent signals from lipopigments associated with various disease states are disclosed.
    Type: Application
    Filed: April 9, 2019
    Publication date: October 10, 2019
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Moungi G. Bawendi, Rakesh Jain, Oliver Thomas Bruns, Jessica Ann Carr, Klaus van Leyen, Wilhelmus Kwanten, Ivy Xiaoyu Chen
  • DEVICE AND METHOD FOR IMAGING SHORTWAVE INFRARED FLUORESCENCE
    Publication number: 20190079010
    Abstract: Systems and methods for measuring short wave infrared fluorescence and autofluorescent signals are disclosed.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 14, 2019
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation d/b/a Massachusets General Hospital
    Inventors: Moungi G. Bawendi, Oliver Thomas Bruns, Jessica Ann Carr, Klaus van Leyen, Yi Zheng, Marianne Aellen
  • INHIBITORS OF HUMAN 12/15-LIPOXYGENASE
    Publication number: 20160168137
    Abstract: A systematic screening has revealed a family of compounds that exhibit inhibitory effects on 12/15-lipoxygenase. Accordingly, the present invention relates to the use of these compounds for the inhibition of 12/15-lipoxygenase and for the treatment of a condition involving 12/15-lipoxygenase. Exemplary conditions include, but are not limited to, stroke, periventricular leukomalacia, cardiac arrest with resuscitation, atherosclerosis, Parkinson's disease, Alzheimer's disease, and breast cancer.
    Type: Application
    Filed: February 19, 2016
    Publication date: June 16, 2016
    Applicants: THE GENERAL HOSPITAL CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SANTA CRUZ, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV
    Inventors: Klaus VAN LEYEN, Theodore R. HOLMAN, David J. MALONEY, Ajit JADHAV, Anton SIMEONOV, Ganesha RAI
  • NOVEL LIPOXYGENASE INHIBITORS AS NEUROPROTECTIVE AGENTS
    Publication number: 20120053220
    Abstract: The present invention relates to the identification of inhibitors of lipoxygenase enzymes. Methods are presented for using novel lipoxygenase inhibitors: LOXBlock-1 and LOXBlock-3, and other candidate lipoxygenase inhibitors identified by similar screening strategies, in therapy and diagnostics for neurodegenerative disorders.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 1, 2012
    Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, Florey Neuroscience Institutes, The Regents of the University of California
    Inventors: Klaus Van Leyen, Theodore R. Holman, Eng H. Lo, Matthew P. Jacobson, David W. Howells
  • Methods and compositions for evaluation and modulation of fertility
    Patent number: 7368249
    Abstract: The present invention concerns compositions and methods for regulating or determining fertility in humans and animals. In various embodiments of the invention, LOX and other related enzymes can be used as fertility markers, contraceptive agents, or means of treating infertility. LOX may be detected in accordance with the invention in vitro or in vivo.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: May 6, 2008
    Assignees: The Curators of the University of Missouri, Slaon-Kettering Institute for Cancer Research
    Inventors: Peter Sutovsky, Klaus van Leyen