Abstract: A diagnosis system and a diagnosis method are provided. More specifically, embodiments of the present disclosure relate to a diagnosis system for detection of corneal degeneration impacting the biomechanical stability of the human cornea and a diagnosis method for detection of corneal degeneration impacting the biomechanical stability of the human cornea. Still more specifically, embodiments of the present disclosure relate to a diagnosis system for early detection of corneal degeneration impacting the biomechanical stability of the human cornea and a diagnosis method for early detection of corneal degeneration impacting the biomechanical stability of the human cornea.

Abstract: The invention relates to an eye-surgical laser apparatus, a use of said apparatus, and to a method for scanning the corneal tissue of an eye before or during eye surgery. The apparatus comprises optics that are adapted to focus a laser beam at a focus within a corneal tissue of an eye, and a detection element adapted to detect light that is formed, at the focus, as a frequency multiple and backscattered or forward emitted. Image information about the inner corneal tissue is then produced from the detected light.

Abstract: Embodiments of the invention provide a method and apparatus for laser-processing a material. In the embodiments, a diffraction-limited beam of pulsed laser radiation is diffracted by a diffraction device to generate a diffracted beam. The diffracted beam is subsequently focused onto the material and is controlled in time and space to irradiate the material at a target position with radiation from a set of radiation pulses of the diffracted beam so that each radiation pulse from the set of radiation pulses is incident at the target position with a cross-sectional portion of the diffracted beam, the cross-sectional portion including a local intensity maximum of the diffracted beam. The beam cross-sectional portions of at least a subset of the pulses of the set include each a different local intensity maximum. In this way, a multi-pulse application for generating a photo-disruption at a target location of the material can be implemented.

Abstract: A method for energy setting of pulsed, focused laser radiation is provided. In the method, a relationship between a threshold pulse energy required for causing irreversible damage in a material and a pulse duration is established. The relationship allows for obtaining a threshold pulse energy for each of a plurality of pulse durations, including one or more pulse durations in a range between 200 fs and smaller. The relationship defines a decreasing threshold pulse energy for a decreasing pulse duration in the range between 200 fs and smaller. For a given pulse duration in the range between 200 fs and smaller, an associated threshold pulse energy is determined based on the established relationship. The pulse energy of the laser radiation is set based on the determined associated threshold pulse energy.

Abstract: A system for refractive ophthalmological surgery, in particular LASIK, has—in addition to the ablation laser and, where appropriate, further optical guidance means (18, 30)—a device (34) for optical coherence tomography as an integrated component, in order to make available results of measurement acquired with this device either for the purpose of representation on a display device and/or for the purpose of control of the ablation.

Abstract: An apparatus for laser-assisted eye treatment comprises a laser device and first and second accessory modules. The laser device is configured to provide focused laser radiation and has a coupling port. The first accessory module may form a patient interface and has a contact surface for an eye. The second accessory module includes a measuring device that performs measurements of the laser radiation. In certain embodiments, the measurements include the measurement of a pulse duration of the laser radiation using a detector operating on the basis of two-photon absorption. The first and second accessory modules are configured to detachably couple to the laser device at the coupling port. Only one accessory module can be coupled to the coupling port at a time. Therefore, the first accessory module must be removed from the coupling port before the second accessory module can be attached to the coupling port.

Abstract: An embodiment of a scanning optical system comprises: an optical source providing a beam of pulsed light of ultra-short pulse duration; a deflector for deflecting the beam through a scan angle; a lens system including a focusing objective for focusing the deflected beam; a dispersion compensating device for reducing dispersion-related distortion of a pulse of the beam by the lens system, the dispersion compensating device including a deformable, dispersive mirror and an actuator device for the mirror; and a controller for controlling the actuator device to change a shape of the mirror in accordance with the scan angle.

Abstract: In an embodiment, a laser apparatus comprises a semiconductor laser, e.g., of the VECSEL type, for generating pulsed laser radiation having a pulse duration in the femtosecond range or shorter and having a pulse repetition rate of at least 100 MHz; a selector for selecting groups of pulses from the laser radiation, each pulse group comprising a plurality of pulses at the pulse repetition rate, wherein the pulse groups are time-displaced by at least 500 ns; a scanner device for scanning a focal point of the laser radiation; a controller for controlling the scanner device based on a control program including instructions that, when executed by the controller, bring about the creation of a LIOB-based photodisruption for each pulse group in a target material, e.g. human eye tissue.

Abstract: In certain embodiments, reducing opaque bubble layers (OBLs) comprises receiving information describing a tissue region of a tissue where laser pulses are applied to yield laser-induced optical breakdowns (LIOBs) in the tissue region. The LIOBs yield bubbles of gas. A concentration of the gas in the tissue region is estimated from the information. One or more laser parameters are adjusted in response to the concentration of the gas to satisfy a critical concentration rule.

Abstract: There is provided an apparatus for recording a depth profile of a biological tissue, in particular a frontal eye section of a human eye, according to the principle of optical coherence tomography, comprising a light source adapted to generate a bundle of light rays, an interferometer arrangement having a beam splitter device adapted to spatially separate the bundle of light rays into a reference beam and a measurement beam directed toward the tissue, a reference beam deflection device adapted to deflect the reference beam, a beam superpositioning device adapted to spatially superimpose the deflected reference beam onto the measurement beam deflected by the tissue into a superpositioned beam, and a detector arrangement for detecting information in the superpositioned beam associated with the difference of the optical path length of the reference beam and the measurement beam.

Abstract: A process for producing an interface unit and also a group of such interface units are specified. The interface unit exhibits a first reference surface for beaming in radiation, a second reference surface for emitting the radiation, and an axis extending in the direction from the first to the second reference surface. The production process comprises the steps of setting an optical path length of the interface unit between the first and second reference surfaces along the axis and the fixing of the set optical path length of the interface unit. The optical path length of the interface unit is set in such a way that radiation of a defined numerical aperture beamed in at the first reference surface exhibits a focus location that is predetermined with respect to the second reference surface in the direction of the axis. A precise and uniform focus location with respect to the second reference surface is obtained.

Abstract: An instrument is proposed for examining or machining a human eye, with an eye-tracker for acquiring eye movements and for outputting a signal that is representative of the acquired eye movements, the eye-tracker including an interferometric image-acquisition device that has been set up for time-resolved acquisition of sectional images of the eye and that operates on the basis of two-dimensional or three-dimensional optical coherence tomography, and also an evaluating module ascertaining the eye movements solely from the sectional images.

Abstract: An embodiment of a scanning optical system comprises: an optical source providing a beam of pulsed light of ultra-short pulse duration; a deflector for deflecting the beam through a scan angle; a lens system including a focusing objective for focusing the deflected beam; a dispersion compensating device for reducing dispersion-related distortion of a pulse of the beam by the lens system, the dispersion compensating device including a deformable, dispersive mirror and an actuator device for the mirror; and a controller for controlling the actuator device to change a shape of the mirror in accordance with the scan angle.

Abstract: A process for configuring a laser device comprising: selecting a pulse length within a range from 1 ps to 1 ns; selecting a wavelength for the laser radiation within a range from 300 nm to 400 nm or within a range from 800 nm to 1100 nm; ascertaining a set of parameter values of the laser device that when the laser device is operated with these parameter values a two-dimensionally extensive separation of tissue of human corneal or lenticular tissue is achieved by stringing together local sites of damage, the set of parameter values including the selected pulse length, the selected wavelength, and values for at least one of the following parameters: a pulse energy, a pulse repetition rate, a fluence per radiation pulse, a number of pulses per site of damage, a scanning speed of a scanning apparatus of the laser device, and a focus diameter.

Abstract: An optical coherence tomography device comprises a light generator, a dispersive medium, an optical coupler and a detector. The light generator is adapted to generate a series of input pulses of coherent light, each input pulse having an input pulse width. The dispersive medium has an input that is optically coupled to the light generator and an output for output pulses. The dispersive medium is adapted to stretch the input pulse width to an output pulse width of each of the output pulses by chromatic dispersion. The optical coupler is adapted to couple the output pulses into a reference arm and a sample arm. The optical coupler is further adapted to superimpose light returning from the reference arm and the sample arm. The detector is adapted to detect an intensity of interference of the superimposed light with a temporal resolution of a fraction of the output pulse width.

Abstract: An apparatus for ophthalmic laser surgery comprises a source (28) for a pulsed femtosecond laser beam, a telescope (32) expanding the laser beam, a scanner (36) downstream of the telescope, for deflecting the laser beam in a plane perpendicular to the beam path, and also an f-theta objective (44) downstream of the scanner, for focusing the laser beam. In accordance with the invention, an entrance lens (52) of the telescope (32) takes the form of a controllable lens of variable refractive power. The entrance lens (52) is preferentially constituted by an electrically controllable liquid lens or liquid-crystal lens.

Abstract: A laser apparatus is controlled by a control program that operates to use laser radiation to generate an incision figure in the cornea of an eye, the incision figure including a an incision that bounds a corneal tissue volume. The control program operates to move the radiation focus in a radiation propogation direction successively in a plurality of superposed planes such that the radiation focus is moved without motion control in the propogation direction. The control program provides, for each plane, for a meandering scan path of the radiation focus that extends outside the tissue volume. The control program operates to allow through to the eye, in each plane, at least such radiation pulses that generate the first incision and to blank, in at least a fraction of the planes, at least a fraction of radiation pulses assigned to regions of the path that are at a distance from the incision.

Abstract: A spectroscopic instrument includes a first optical component for spatial spectral splitting of a polychromatic beam of light impinging onto the first optical component, an objective, which routes various spectral regions of the split beam of light onto differing spatial regions, and a sensor, situated downstream of the objective in the beam path of the beam of light, with a plurality of light-sensitive sensor elements. The sensor elements are arranged in the beam path of the split beam of light in such a manner that each sensor element registers the intensity of a spectral sector of the beam of light and the medians of the spectral sectors are situated equidistant from one another in the k-space, where k denotes the wavenumber.

Abstract: In certain embodiments, a system (10) comprises a laser source (20), one or more optical elements (24), a monitoring device (28), and a control computer (30). The laser source (20) emits one or more laser pulses. The optical elements (24) change a pulse length of the laser pulses, and the monitoring device (28) measures the pulse length of the laser pulses to detect the change in the pulse length. The control computer (30) receives the measured pulse length from the monitoring device (28), determines one or more laser parameters that compensate for the change in the pulse length, and controls the laser source (20) according to the laser parameters.

Abstract: An interface unit for positioning an object to be irradiated in relation to a radiation source has at least one first positioning surface for positioning the interface unit in relation to the radiation source, and a second positioning surface for bearing on the object to be irradiated. The interface unit provides a path, which passes through the second positioning surface, for the radiation from the radiation source. According to the invention, the interface unit comprises an integrally produced interface body which forms both the at least one first positioning surface and the second positioning surface. The interface body is preferably produced from a plastic material by an injection compression molding method, in order to achieve the desired high manufacturing accuracy.