Abstract: The present invention relates to the field of blood coagulation, more specifically it relates to a method of treating a thromboembolic disorder by administering once daily a direct factor Xa inhibitor in oral dosage form to a patient in need thereof, wherein the factor Xa inhibitor has a plasma concentration half life indicative of a bid or tid administration interval, e.g. of 10 hours or less.

Abstract: The present invention relates to the field of blood coagulation, more specifically it relates to a method of treating a thromboembolic disorder by administering once daily a direct factor Xa inhibitor in oral dosage form to a patient in need thereof, wherein the factor Xa inhibitor has a plasma concentration half life indicative of a bid or tid administration interval, e.g. of 10 hours or less.

Abstract: 2-Thiazolyl tetrazolium salt compounds characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

Abstract: Phenyl substituted 2-thiazolyl tetrazolium salt compounds characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

Abstract: The present invention is directed to the use of polymer blend films consisting of polycarbonate and polyalkylene terephthalate supports for diagnostic test strips.

Abstract: Naphthotriazolium salts which are chromogenic indicators for reducing substrate, such as NADH or NADPH.

Abstract: General classes of 2-thiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

Abstract: The present invention relates to a process for the production of porous, and particularly macroporous, membranes. The membranes produced by the process are highly absorbent and can therefore be employed, as supporting matrices for test strips. These test strips can be used for the detection of substances to be analyzed in a liquid.

Abstract: The present invention is related to compounds of the general formula (I) ##STR1## wherein R.sup.1 denotes hydrogen, halogen or C.sub.1 -C.sub.4 alkyl andR.sup.2 denotes C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl, or a substituted C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl and their preparation. The compounds can be used in an iron assay system.

Abstract: The present invention is related to compounds of the general formula (I) ##STR1## wherein R.sup.1 denotes hydrogen, halogen or C.sub.1 -C.sub.4 alkyl andR.sup.2 denotes C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl, or a substituted C.sub.1 -C.sub.4 alkyl, aryl or heteroaryl and their preparation. The compounds can be used in an iron assay system.

Abstract: Indicators for the detection of thio groups are disclosed together with processes for the preparation of such indicators.

Abstract: A method for detecting hydrogen peroxide wherein a sample is contacted with a peroxidase or a peroxidatively-active substance and a redox indicator of the following ##STR1## in which A and D independently of one another represent phenyl, pyridyl or imidazolyl,G represents O, CH.sub.2 or S,m represents the number zero or one, andX represents O, ##STR2## or --NR.sup.1 --NR.sup.2 -- R.sup.1 and R.sup.2, independently of one another, denote hydrogen, alkyl, cycloalkyl, aryl or aralkyl, or --NR.sup.1 R.sup.2 together represent a pyrrolidine, pyrazoline, piperidine, piperazine or morpholine radical andT denotes hydrogen, hydroxyl, alkyl, aryl, alkoxy, phenoxy, SO.sub.3 H, --COOH or ##STR3## whereby a color change is brought out if hydrogen peroxide is present.

Abstract: 2-Hydrazono-4,6-dinitrobenzthiazolones of the formula ##STR1## in which X.sub.1 represents hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -hydroxyalkyl, C.sub.1 -C.sub.4 -sulphoalkyl or C.sub.1 -C.sub.4 -sulphatoalkyl, andX.sub.2 represents hydrogen or --SO.sub.2 X.sub.3, whereX.sub.3 may represent hydrogen, C.sub.1 -C.sub.8 -alkyl or optionally substituted aryl andX.sub.1 also represents a double bond between the cyclic nitrogen atom and the carbon atom 2 according to the formula II below: ##STR2## where X.sub.2 has the meaning specified under the above formula. These hydrazones may be employed in the preparation of azo dyestuffs and as color formers for detecting of biological substances, and in the determination of H.sub.2 O.sub.2.

Abstract: Indicators for the detection of thio groups are disclosed together with processes for the preparation of such indicators.

Abstract: Indicators for the detection of thio groups are disclosed together with processes for the preparation of such indicators.

Abstract: The invention relates to new dicyanoethylaryl derivatives and to processes for their preparation. The compounds according to the invention can be used as redox indicators, such as, for example, for the detection of hydrogen peroxide with the aid of peroxidases or peroxidatively active substances.These redox indicators are futhermore suitable for the detection of peroxidases or peroxidatively active compounds, it also being possible to use other peroxides as oxidizing agents.

Abstract: A transparent reagent carrier layers in analytical agents for dry chemical detection of constituents of aqueous sample solutions, the reagent carrier layer consisting of a water-soluble or water-swellable component and a film-forming component.

Abstract: A reagent for the determination of haemoglobin comprising an aqueous solution of potassium cyanide, potassium hexacyanoferrate-III, a buffer substance and a detergent, wherein the pH value is in the range of 7.1 to 7.3 and the potassium cyanide concentration is in the 90 to 120 mg/liter range. The reagent can be used with plastic throw-away cells, particularly polystyrene cells.