Patents by Inventor Klaus WENING
Klaus WENING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180221307Abstract: The invention relates to a monolithic pharmaceutical dosage form comprising a hot melt-extruded first segment (S1) and a second segment (S2); wherein the first segment (S1) contains at least a first pharmacologically active ingredient (A1) and/or the second segment (S2) contains at least a second pharmacologically active ingredient (A2); and the segment (S1) and/or the segment (S2) is tamper-resistant and/or exhibits a breaking strength of at least 300 N.Type: ApplicationFiled: January 30, 2018Publication date: August 9, 2018Applicant: GRÜNENTHAL GMBHInventors: ANJA GEIßLER-FICHTNER, Klaus Wening, Lutz Barnscheid, Jana Pätz
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Publication number: 20180078544Abstract: A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.Type: ApplicationFiled: November 28, 2017Publication date: March 22, 2018Applicant: GRÜNENTHAL GMBHInventors: KLAUS WENING, ANJA GEIßLER, JANA DENKER, LUTZ BARNSCHEID
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Publication number: 20180044347Abstract: Crystalline salts of 4,5 ?-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) (hydrocodone bitartrate) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a pharmaceutical composition comprising such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.Type: ApplicationFiled: October 24, 2017Publication date: February 15, 2018Applicant: GRÜNENTHAL GMBHInventors: Klaus WENING, Lutz BARNSCHEID, Anja GEISSLER, Jana DENKER, Dagmar LISCHKE
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Publication number: 20180044348Abstract: Crystalline salts of 7,8-Didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6 alpha-diol sulfate(2:1), i.e. of morphine sulphate, are disclosed and four polymorphic forms of these salts are reported. The invention further relates to a pharmaceutical composition comprising an amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.Type: ApplicationFiled: October 24, 2017Publication date: February 15, 2018Applicant: Grünenthal GmbhInventors: Klaus WENING, Lutz BARNSCHEID, Anja GEISSLER, Jana DENKER, Dagmar LISCHKE
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Publication number: 20180042868Abstract: A pharmaceutical dosage form having a breaking strength of at least 300 N and comprising an ephedrine component selected from the group consisting of ephedrine, pseudoephedrine and the physiologically acceptable salts thereof, wherein the weight content of the ephedrine component is within the range of from 0.1 to 60 wt.-%, relative to the total weight of the pharmaceutical dosage form.Type: ApplicationFiled: August 11, 2017Publication date: February 15, 2018Applicant: GRÜNENTHAL GMBHInventors: Carmen STOMBERG, Klaus WENING, Sebastian SCHWIER
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Publication number: 20180028670Abstract: A pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising: an opioid (A) selected from Oxymorphone, Oxycodone, Tapentadol, Hydromorphone, Hydrocodone, Morphine, and physiologically acceptable salts thereof; wherein the weight content of the opioid (A) is from 5.0 to 35 wt.-%; an anionic polysaccharide (B) selected from croscarmellose, carmellose, crosslinked carboxymethyl starch, carboxymethyl starch, and physiologically acceptable salts thereof; wherein the weight content of the anionic polysaccharide (B) is within from 5.0 to 35 wt.-%; and a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol; wherein the weight content of the polyalkylene oxide (C) is from 20 to 80 wt.-%; wherein all wt.-%'s are based on a total weight of the dosage form, and the opioid (A) is present in a controlled-release matrix comprising the anionic polysaccharide (B) and the polyalkylene oxide (C).Type: ApplicationFiled: August 1, 2017Publication date: February 1, 2018Applicant: Grünenthal GMBHInventors: Klaus WENING, Carmen Stomberg
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Patent number: 9872835Abstract: The invention relates to an oral pharmaceutical dosage form providing resistance against dose dumping in aqueous ethanol and comprising a pharmacologically active ingredient embedded in a matrix material, wherein the matrix material comprises an alkyl cellulose and a heteropolysaccharide; and wherein the relative weight ratio of heteropolysaccharide to alkyl cellulose is within the range of from 1:20 to 20:1; and wherein the total content of alkyl cellulose and heteropolysaccharide is at least 35 wt.-%, relative to the total weight of the dosage form. A process of producing the dosage form and methods of using the dosage form, for example to treat pain, are also disclosed.Type: GrantFiled: May 22, 2015Date of Patent: January 23, 2018Assignee: GRÜNENTHAL GMBHInventors: Lutz Barnscheid, Klaus Wening, Jana Pätz, Anja Geissler
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Patent number: 9855263Abstract: A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.Type: GrantFiled: June 1, 2016Date of Patent: January 2, 2018Assignee: GRÜNENTHAL GMBHInventors: Klaus Wening, Anja Geiβler, Jana Denker, Lutz Barnscheid
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Publication number: 20170296476Abstract: The invention relates to a pharmaceutical dosage form for oral administration comprising a pharmacologically active compound; wherein a portion of said pharmacologically active compound is contained in a multitude of immediate release particles providing immediate release of the pharmacologically active compound; wherein another portion of said pharmacologically active compound is contained in at least one controlled release particle providing controlled release of the pharmacologically active compound; and wherein the breaking strength of each of the immediate release particles and/or of the at least one controlled release particle is at least 300 N.Type: ApplicationFiled: April 17, 2017Publication date: October 19, 2017Applicant: GRÜNENTHAL GMBHInventors: KLAUS WENING, HARALD PAUL, SEBASTIAN SCHWIER, CARMEN STOMBERG
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Publication number: 20170296472Abstract: The invention relates to a pharmaceutical dosage form comprising (i) at least one formed segment (S1), which contains a first pharmacologically active ingredient (A1) and provides prolonged release thereof, and (ii) at least one further segment (S2), which contains a second pharmacologically active ingredient (A2) and provides immediate release thereof, wherein the at least one formed segment (S1) exhibits a higher breaking strength than the at least one further segment (S2) and the at least one formed segment (S1) exhibits a breaking strength of more than 500 N.Type: ApplicationFiled: June 29, 2017Publication date: October 19, 2017Applicant: GRÜNENTHAL GMBHInventors: Lutz BARNSCHEID, Anja Geissler, Klaus Wening, Stefanie Strauch, Jana Pätz, Sebastian Schwier
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Patent number: 9737490Abstract: The invention relates to a pharmaceutical dosage form comprising (i) at least one formed segment (S1), which contains a first pharmacologically active ingredient (A1) and provides prolonged release thereof, and (ii) at least one further segment (S2), which contains a second pharmacologically active ingredient (A2) and provides immediate release thereof, wherein the at least one formed segment (S1) exhibits a higher breaking strength than the at least one further segment (S2) and the at least one formed segment (S1) exhibits a breaking strength of more than 500 N.Type: GrantFiled: May 27, 2014Date of Patent: August 22, 2017Assignee: GRÜNENTHAL GMBHInventors: Lutz Barnscheid, Anja Geiβler, Klaus Wening, Stefanie Strauch, Jana Pätz, Sebastian Schwier
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Publication number: 20170112766Abstract: A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.Type: ApplicationFiled: January 9, 2017Publication date: April 27, 2017Applicant: GRÜNENTHAL GMBHInventors: KLAUS WENING, ANJA GEIßLER, JANA DENKER, LUTZ BARNSCHEID
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Publication number: 20170071862Abstract: The invention relates to a pharmaceutical dosage form which is particularly useful for the prevention of an overdose of the pharmacologically active ingredient contained therein after accidental or intentional simultaneous administration of a plurality of the dosage forms containing an overall supratherapeutic dose of the pharmacologically active ingredient.Type: ApplicationFiled: September 9, 2016Publication date: March 16, 2017Applicant: GRÜNENTHAL GMBHInventors: KLAUS WENING, Sebastian Schwier, Ulrike Bertram
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Publication number: 20160338976Abstract: Summary: The invention relates to a monolithic pharmaceutical dosage form comprising a hot melt-extruded first segment (S1) and a second segment (S2); wherein the first segment (S1) contains at least a first pharmacologically active ingredient (A1) and/or the second segment (S2) contains at least a second pharmacologically active ingredient (A2); and the segment (S1) and/or the segment (S2) is tamper-resistant and/or exhibits a breaking strength of at least 300 N.Type: ApplicationFiled: August 5, 2016Publication date: November 24, 2016Applicant: GRÜNENTHAL GMBHInventors: ANJA GEIßLER, KLAUS WENING, LUTZ BARNSCHEID, JANA PÄTZ
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TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM DIFFERENT PARTICLES
Publication number: 20160310428Abstract: A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.Type: ApplicationFiled: April 22, 2016Publication date: October 27, 2016Applicant: GRUNENTHAL GMBHInventors: KLAUS WENING, LUTZ BARNSCHEID, ANJA GEISSLER, JANA DENKER, JESSICA REDMER -
Publication number: 20160310486Abstract: A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.Type: ApplicationFiled: April 22, 2016Publication date: October 27, 2016Applicant: GRÜNENTHAL GMBHInventors: Klaus WENING, Lutz BARNSCHEID, Anja GEIßLER, Jana DENKER, Jessica REDMER
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Publication number: 20160310437Abstract: A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.Type: ApplicationFiled: April 22, 2016Publication date: October 27, 2016Applicant: GRÜNENTHAL GMBHInventors: KLAUS WENING, LUTZ BARNSCHEID, ANJA GEISSLER, JANA DENKER, JESSICA REDMER
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Publication number: 20160310429Abstract: A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.Type: ApplicationFiled: April 22, 2016Publication date: October 27, 2016Applicant: GRÜNENTHAL GMBHInventors: KLAUS WENING, ANJA GEIßLER, JANA DENKER, LUTZ BARNSCHEID
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Publication number: 20160310487Abstract: A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.Type: ApplicationFiled: June 1, 2016Publication date: October 27, 2016Applicant: GRUNENTHAL GMBHInventors: Klaus WENING, Anja GEIßLER, Jana DENKER, Lutz BARNSCHEID
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Publication number: 20160310427Abstract: A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.Type: ApplicationFiled: April 22, 2016Publication date: October 27, 2016Applicant: GRÜNENTHAL GMBHInventors: KLAUS WENING, LUTZ BARNSCHEID, ANJA GEISSLER, JANA DENKER, JESSICA REDMER