Patents by Inventor Klavs F. Jensen
Klavs F. Jensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10988504Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: GrantFiled: September 5, 2017Date of Patent: April 27, 2021Assignee: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Patent number: 10889613Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: GrantFiled: May 22, 2017Date of Patent: January 12, 2021Assignee: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Patent number: 10870112Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.Type: GrantFiled: September 28, 2018Date of Patent: December 22, 2020Assignee: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Viktor A. Adalsteinsson, Nahyun Cho, Robert S. Langer, J. Christopher Love, Klavs F. Jensen
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Publication number: 20200368710Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.Type: ApplicationFiled: August 10, 2020Publication date: November 26, 2020Applicant: Massachusetts Institute of TechnologyInventors: Klavs F. Jensen, Timothy F. Jamison, Allan S. Myerson, Jean-Christophe M. Monbaliu, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Eve Marie Revalor, Torsten Stelzer, Jie Chen, Andrea Adamo, David R. Snead, Ping Zhang
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Patent number: 10792639Abstract: Aspects of the present disclosure relate to reconfigurable chemical synthesis systems and related components and methods. In one aspect, a fluidic system comprises a plurality of fluid outlets, a plurality of fluid inlets, a plurality of tensioners, and a plurality of flexible conduits associated with the plurality of tensioners, wherein at least one flexible conduit of the plurality of flexible conduits is configured to fluidically connect a fluid outlet of the plurality of fluid outlets and a fluid inlet of the plurality of fluid inlets. Another aspect relates to a method in which ends of a plurality of flexible conduits are physically moved along paths, one after the other, prior to flowing material through the flexible conduits, after which the ends of the flexible conduits are again physically moved.Type: GrantFiled: April 16, 2018Date of Patent: October 6, 2020Assignee: Massachusetts Institute of TechnologyInventors: Klavs F. Jensen, Dale Arlington Thomas, III
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Patent number: 10780410Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.Type: GrantFiled: August 14, 2015Date of Patent: September 22, 2020Assignee: Massachusetts Institute of TechnologyInventors: Klavs F. Jensen, Timothy F. Jamison, Allan S. Myerson, Jean-Christophe M. Monbaliu, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Eve Marie Revalor, Torsten Stelzer, Jie Chen, Andrea Adamo, David R. Snead, Ping Zhang
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Publication number: 20200277566Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.Type: ApplicationFiled: March 13, 2020Publication date: September 3, 2020Applicant: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Andrea Adamo, Robert S. Langer, Klavs F. Jensen
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Patent number: 10696944Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.Type: GrantFiled: October 17, 2012Date of Patent: June 30, 2020Assignee: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Andrea Adamo, Robert S. Langer, Klavs F. Jensen
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Patent number: 10622098Abstract: Techniques for predicting a chemical reaction that includes a set of input molecules. The techniques may include obtaining input molecule information identifying the set of input molecules and predicting at least one chemical reaction that include a transformation between the set of input molecules and a set of output molecules by modifying at least one reaction center of the set of input molecules. The predicting of the at least one chemical reaction may be performed at least in part by using the input molecule information and at least one statistical model relating properties of atoms outside a region of a molecule to reactivity of the molecule at the region to identify the at least one reaction center. The techniques further include outputting information indicating the set of output molecules.Type: GrantFiled: August 29, 2018Date of Patent: April 14, 2020Assignee: Massachusetts Institute of TechnologyInventors: Connor Wilson Coley, Klavs F. Jensen, Regina Barzilay, Tommi S. Jaakkola, Wengong Jin
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Publication number: 20200027528Abstract: Techniques for predicting a chemical reaction that includes a set of input molecules. The techniques may include obtaining input molecule information identifying the set of input molecules and predicting at least one chemical reaction that include a transformation between the set of input molecules and a set of output molecules by modifying at least one reaction center of the set of input molecules. The predicting of the at least one chemical reaction may be performed at least in part by using the input molecule information and at least one statistical model relating properties of atoms outside a region of a molecule to reactivity of the molecule at the region to identify the at least one reaction center. The techniques further include outputting information indicating the set of output molecules.Type: ApplicationFiled: August 29, 2018Publication date: January 23, 2020Applicant: Massachusetts Institute of TechnologyInventors: Connor Wilson Coley, Klavs F. Jensen, Regina Barzilay, Tommi S. Jaakkola, Wengong Jin
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Patent number: 10526573Abstract: A microfluidic system for causing perturbations in a cell membrane includes (a) a microfluidic channel defining a lumen and configured such that a cell suspended in a buffer can pass there through, and (b) source or emitter of an energy field. The microfluidic channel may include a cell-deforming constriction. A diameter of the constriction may be a function of the diameter of the cell. Related apparatus, systems, techniques, and articles are also described.Type: GrantFiled: November 13, 2015Date of Patent: January 7, 2020Assignee: Massachusetts Institute of TechnologyInventors: Xiaoyun Ding, Armon R. Sharei, Robert S. Langer, Klavs F. Jensen
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Publication number: 20190275520Abstract: Methods and apparatus that facilitate membrane-perturbing surface interactions for delivering a payload to a variety of cell types without resulting in a substantial loss in cell viability or alteration of endogenous cellular functions. In one example, an intracellular delivery tool comprises a microfluidic device (10) which includes a microfluidic flow channel (12) containing fluid therein and a membrane perturbing surface (22), in fluid communication with the microfluidic flow channel (12), with a plurality of perturbing features disposed thereon. An exemplary intracellular delivery method includes flowing a fluid containing cells therein along a membrane perturbing surface having a plurality of perturbing features disposed thereon, and delivering nanomaterial across a membrane of the cells in the fluid during and after contact between the cells and the membrane perturbing surface.Type: ApplicationFiled: March 31, 2017Publication date: September 12, 2019Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Martin P. STEWART, Robert S. LANGER, Klavs F. JENSEN, Xiaoyun DING
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Publication number: 20190126229Abstract: The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.Type: ApplicationFiled: May 2, 2017Publication date: May 2, 2019Applicant: Massachusetts Institute of TechnologyInventors: Andrea Adamo, Dale Arlington Thomas, III, Klavs F. Jensen, Timothy F. Jamison, Aaron A. Bedermann, Kosisochukwu C. Aroh
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Patent number: 10252239Abstract: According to some aspects, described herein is an automated droplet-based reactor that utilizes oscillatory motion of a droplet in a tubular reactor under inert atmosphere. In some cases, such a reactor may address current shortcomings of continuous multi-phase flow platforms.Type: GrantFiled: August 12, 2016Date of Patent: April 9, 2019Assignee: Massachusetts Institute of TechnologyInventors: Milad Abolhasani, Connor Wilson Coley, Klavs F. Jensen
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Publication number: 20190093073Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.Type: ApplicationFiled: September 25, 2018Publication date: March 28, 2019Applicant: Massachusetts Institute of TechnologyInventors: Armon R Sharei, Andrea Adamo, Robert S. Langer, Klavs F. Jensen
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Publication number: 20190030536Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.Type: ApplicationFiled: September 28, 2018Publication date: January 31, 2019Applicant: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Viktor A. Adalsteinsson, Nahyun Cho, Robert S. Langer, J. Christopher Love, Klavs F. Jensen
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Patent number: 10124336Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.Type: GrantFiled: August 15, 2014Date of Patent: November 13, 2018Assignee: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Viktor A. Adalsteinsson, Nahyun Cho, Robert S. Langer, J. Christopher Love, Klavs F. Jensen
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Publication number: 20180311638Abstract: Aspects of the present disclosure relate to reconfigurable chemical synthesis systems and related components and methods. In some embodiments, the described systems comprise one or more fluidic connector units, wherein each fluidic connector unit comprises a plurality of flexible conduits. In certain cases, a system comprising one or more fluidic connector units is configured to synthesize a first chemical compound by providing a plurality of fluidic connections between a plurality of fluid outlets (e.g., outlets of chemical reagent sources, outlets of pumps) and a plurality of fluid inlets (e.g., inlets of reaction modules, inlets of pumps) through the plurality of flexible conduits. In certain cases, the system is subsequently reconfigured by resetting the system (e.g., disconnecting each fluidic connection) and/or configuring the system to synthesize a second, different chemical compound (e.g., disconnecting one or more fluidic connections and providing one or more additional fluidic connections).Type: ApplicationFiled: April 16, 2018Publication date: November 1, 2018Applicant: Massachusetts Institute of TechnologyInventors: Klavs F. Jensen, Dale Arlington Thomas, III
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Publication number: 20180207604Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.Type: ApplicationFiled: August 14, 2015Publication date: July 26, 2018Applicant: Massachusettts Institute of TechnologyInventors: Klavs F. Jensen, Timothy F Jamision, Allan S Myerson, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Marie REvalor Rognes
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Publication number: 20180201889Abstract: The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system, loading of red blood cells with macromolecules of different sizes has been shown. Although delivery to some mammalian cells, such as cancer cell lines and fibroblasts had been previously demonstrated using this technique, those designs were incompatible with RBCs that have dramatically different physical properties. Through the use of smaller constriction sizes, high speeds and different buffers successful delivery to red blood cells can be achieved. By enabling robust delivery to red blood cells in a simple, scalable manner, the current subject matter can be implemented in a diversity of applications that deliver material to study red blood cell diseases and/or use red blood cells as a therapeutic platform. Related apparatus, systems, techniques, and articles are also described.Type: ApplicationFiled: January 9, 2018Publication date: July 19, 2018Inventors: Armon R. Sharei, Klavs F. Jensen, James Robbins Abshire, Jacquin Clarence Niles