Patents by Inventor Kleomenis K. Barlos

Kleomenis K. Barlos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ANCHORED LYSINE
    Publication number: 20210388051
    Abstract: The present application discloses the preparation of peptides, including insulin and insulin derivatives, using efficient methods for solid-phase and solution phase peptide synthesis.
    Type: Application
    Filed: June 16, 2021
    Publication date: December 16, 2021
    Inventors: Kleomenis K. Barlos, Konstantinos Barlos, Dimitrios Gatos, Michail Ziovas, Efstathios Liopyris
  • Solid phase peptide synthesis via side chain attachment
    Patent number: 10183966
    Abstract: The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: January 22, 2019
    Assignee: CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A.
    Inventor: Kleomenis K. Barlos
  • SOLID PHASE PEPTIDE SYNTHESIS VIA SIDE CHAIN ATTACHMENT
    Publication number: 20160362445
    Abstract: The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.
    Type: Application
    Filed: June 14, 2016
    Publication date: December 15, 2016
    Inventor: Kleomenis K. BARLOS
  • Solid phase peptide synthesis via side chain attachment
    Patent number: 9388212
    Abstract: The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: July 12, 2016
    Assignee: CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A.
    Inventor: Kleomenis K. Barlos
  • SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ACHORED LYSINE
    Publication number: 20160031962
    Abstract: The present application discloses the preparation of peptides, including insulin and insulin derivatives, using efficient methods for solid-phase and solution phase peptide synthesis.
    Type: Application
    Filed: April 20, 2012
    Publication date: February 4, 2016
    Inventor: Kleomenis K. BARLOS
  • Peptide synthesis
    Patent number: 8785384
    Abstract: A process for producing an insulin type peptide, for example a relaxin, involving oxidizing a methionine residue on a B-chain having cysteine residues and combining the B chain with an A chain having cysteine residues to form a peptide having intermolecular disulphide links and biological activity. Novel synthetic relaxin 1 and methionine oxidized relaxins and Met(O) B-chains having enhanced solubility are disclosed.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: July 22, 2014
    Assignee: Chemical & Biopharmaceutical Laboratories of Patras
    Inventor: Kleomenis K. Barlos
  • Peptide Synthesis
    Publication number: 20110039778
    Abstract: A process for producing an insulin type peptide, for example a relaxin, involving oxidizing a methionine residue on a B-chain having cysteine residues and combining the B chain with an A chain having cysteine residues to form a peptide having intermolecular disulphide links and biological activity. Novel synthetic relaxin 1 and methionine oxidized relaxins and Met(O) B-chains having enhanced solubility are disclosed.
    Type: Application
    Filed: May 19, 2010
    Publication date: February 17, 2011
    Inventor: Kleomenis K. Barlos