Patents by Inventor Klim King

Klim King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions, kits and methods for treating type II diabetes mellitus
    Patent number: 11020447
    Abstract: Disclosed herein are methods for treating type II diabetes mellitus. In particular, the present invention relates to methods of using an extract of Hedychium coronarium Koenig and a blood glucose reduction agent, to synergistically reduce the blood glucose level of the subject having type II diabetes mellitus.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: June 1, 2021
    Assignee: VITNOVO, INC.
    Inventors: Pei-Ran Wang, Rey-Yuh Wu, Yu-Yuan Wu, Lung-Yu Kuan, Klim King
  • Use of overground part of Koenig in reducing blood glucose; extracts and compositions of overground part of Koenig and their uses
    Patent number: 10561700
    Abstract: The present invention is related to the use of an overground part of Hedychium coronarium Koenig in lowering blood glucose, increasing insulin levels and treating and/or preventing diabetes without overly reducing blood glucose in a subject; i.e., not reducing blood glucose in a fasting subject. The present invention also relates to an extract and composition of the overground part of Hedychium coronarium Koenig and its use in lowering blood glucose, increasing insulin levels and treating and/or preventing diabetes.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: February 18, 2020
    Assignee: Development Center for Biotechnology
    Inventors: Rey Yuh Wu, Yu-Yuan Wu, Lung-Yu Kuan, Klim King
  • Biosensor for detecting intracellular cyclic adenosine monophosphate (cAMP) and uses thereof
    Patent number: 10408813
    Abstract: Cyclic adenosine monophosphate (cAMP) biosensors comprising a Renilla luciferase (RLuc), a green fluorescent protein (GFP), and an exchange protein activated by cAMP, and uses thereof in determining cAMP levels both in vivo and in vitro. Another aspect of the invention relates to methods for controlling blood glucose levels.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: September 10, 2019
    Assignee: Academia Sinica
    Inventors: Klim King, Yu-Heng Cheng
  • Glucagon-like peptide 1 modulator and uses thereof
    Patent number: 10392357
    Abstract: Disclosed herein are novel glucagon-like peptide-1 (GLP-1) modulators and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders associated with hyperglycemia.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 27, 2019
    Assignee: Acaemia Sinica
    Inventors: Rong-Jie Chein, Klim King, Nai-Pin Lin, Yu-Hong Cheng
  • COMPOSITIONS, KITS AND METHODS FOR TREATING TYPE II DIABETES MELLITUS
    Publication number: 20190183959
    Abstract: Disclosed herein are methods for treating type II diabetes mellitus. In particular, the present invention relates to methods of using an extract of Hedychium coronarium Koenig and a blood glucose reduction agent, to synergistically reduce the blood glucose level of the subject having type II diabetes mellitus.
    Type: Application
    Filed: December 17, 2018
    Publication date: June 20, 2019
    Applicant: VITNOVO, INC.
    Inventors: Pei-Ran WANG, Rey-Yuh WU, Yu-Yuan WU, Lung-Yu KUAN, Klim KING
  • NOVEL GLUCAGON-LIKE PEPTIDE 1 MODULATOR AND USES THEREOF
    Publication number: 20180179172
    Abstract: Disclosed herein are novel glucagon-like peptide-1 (GLP-1) modulators and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders associated with hyperglycemia.
    Type: Application
    Filed: June 30, 2016
    Publication date: June 28, 2018
    Applicant: Academia Sinica
    Inventors: Rong-Jie CHIEN, Klim KING, Nai-Pin LIN, Yu-Hong CHENG
  • COMPOSITIONS, KITS AND METHODS FOR TREATING TYPE II DIABETES MELLITUS
    Publication number: 20180140653
    Abstract: Disclosed herein are methods for treating type II diabetes mellitus. In particular, the present invention relates to methods of using an extract of Hedychium coronarium Koenig and a blood glucose reduction agent, to synergistically reduce the blood glucose level of the subject having type II diabetes mellitus.
    Type: Application
    Filed: December 18, 2017
    Publication date: May 24, 2018
    Applicant: VITNOVO, INC.
    Inventors: Pei-Ran WANG, Rey-Yuh WU, Yu-Yuan WU, Lung-Yu KUAN, Klim KING
  • USE OF OVERGROUND PART OF HEDYCHIUM CORONARIUM KOENIG IN REDUCING BLOOD GLUCOSE; EXTRACTS AND COMPOSITIONS OF OVERGROUND PART OF HEDYCHIUM CORONARIUM KOENIG AND THEIR USES
    Publication number: 20170087201
    Abstract: The present invention is related to the use of an overground part of Hedychium coronarium Koenig in lowering blood glucose, increasing insulin levels and treating and/or preventing diabetes without overly reducing blood glucose in a subject; i.e., not reducing blood glucose in a fasting subject. The present invention also relates to an extract and composition of the overground part of Hedychium coronarium Koenig and its use in lowering blood glucose, increasing insulin levels and treating and/or preventing diabetes.
    Type: Application
    Filed: November 22, 2016
    Publication date: March 30, 2017
    Inventors: Rey Yuh Wu, Yu-Yuan Wu, Lung-Yu Kuan, Klim King
  • BIOSENSOR FOR DETECTING INTRACELLULAR CYCLIC ADENOSINE MONOPHOSPHATE (cAMP) AND USES THEREOF
    Publication number: 20160313251
    Abstract: Cyclic adenosine monophosphate (cAMP) biosensors comprising a Renilla luciferase (RLuc), a green fluorescent protein (GFP), and an exchange protein activated by cAMP, and uses thereof in determining cAMP levels both in vivo and in vitro. Another aspect of the invention relates to methods for controlling blood glucose levels.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Inventors: Klim KING, Yu-Heng CHENG
  • DELTA OPIOID RECEPTOR AGONIST COMPOUNDS
    Publication number: 20160200689
    Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
    Type: Application
    Filed: March 23, 2016
    Publication date: July 14, 2016
    Inventors: KWEN-JEN CHANG, KLIM KING, KESTUTIS P. BICIUNAS, ROBERT W. MCNUTT, WILLIAM PENDERGAST, SHYI-TAI JAN
  • Delta opioid receptor agonist compounds
    Patent number: 9296707
    Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: March 29, 2016
    Assignee: VERSI GROUP, LLC
    Inventors: Kwen-Jen Chang, Klim King, Kestutis P. Biciunas, Robert W. McNutt, William Pendergast, Shyi-Tai Jan
  • GLUCAGON-LIKE PEPTIDE 1 (GLP-1) RECEPTOR MODULATORS AND USES THEREOF IN REGULATING BLOOD GLUCOSE LEVELS
    Publication number: 20150197480
    Abstract: The present disclosure provides novel glucagon-like peptide-1 (GLP-1) receptor modulators such as compounds of Formula (I) or (II), and pharmaceutically acceptable salts thereof. The present disclosure also provides pharmaceutical compositions, kits, and uses that involve the GLP-1 receptor modulators for regulating blood glucose levels and/or treating diabetes via, e.g., modulating the endogenous signaling pathways mediated by the GLP-1 receptor.
    Type: Application
    Filed: May 27, 2014
    Publication date: July 16, 2015
    Applicants: Academia Sinica
    Inventors: Klim King, Rong-Jie Chein
  • DELTA OPIOID RECEPTOR AGONIST COMPOUNDS
    Publication number: 20150018372
    Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
    Type: Application
    Filed: October 1, 2014
    Publication date: January 15, 2015
    Inventors: KWEN-JEN CHANG, KLIM KING, KESTUTIS P. BICIUNAS, ROBERT W. MCNUTT, WILLIAM PENDERGAST, SHYI-TAI JAN
  • SYNTHESIS OF GALANAL COMPOUNDS AND ANALOGUES THEREOF
    Publication number: 20140350288
    Abstract: The present disclosure provides methods of preparing glucagon-like peptide-1 (GLP-1) receptor modulators, such as compounds of Formula (II) or (VI), or intermediates thereof. The compounds that may be prepared by the described methods are useful for regulating blood glucose levels and/or treating a disease mediated by a GLP-1 receptor (e.g., diabetes).
    Type: Application
    Filed: May 27, 2014
    Publication date: November 27, 2014
    Applicants: Academia Sinica, Chi-Ming Liang
    Inventors: Klim King, Rong-Jie Chein
  • GLUCAGON-LIKE PEPTIDE 1 (GLP-1) RECEPTOR MODULATORS AND USES THEREOF IN REGULATING BLOOD GLUCOSE LEVELS
    Publication number: 20140350100
    Abstract: The present disclosure provides novel glucagon-like peptide-1 (GLP-1) receptor modulators such as compounds of Formula (I) or (II), and pharmaceutically acceptable salts thereof. The present disclosure also provides pharmaceutical compositions, kits, and uses that involve the GLP-1 receptor modulators for regulating blood glucose levels and/or treating diabetes via, e.g., modulating the endogenous signaling pathways mediated by the GLP-1 receptor.
    Type: Application
    Filed: May 27, 2014
    Publication date: November 27, 2014
    Applicants: Academia Sinica
    Inventors: Klim King, Rong-Jie Chein
  • Delta opioid receptor agonist compounds
    Patent number: 8865721
    Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: October 21, 2014
    Assignee: Versi Group, LLC
    Inventors: Kwen-Jen Chang, Klim King, Kestutis P. Biciunas, Robert W. McNutt, William Pendergast, Shyi-Tan Jan
  • DELTA OPIOID RECEPTOR AGONIST COMPOUNDS
    Publication number: 20140031367
    Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
    Type: Application
    Filed: October 1, 2013
    Publication date: January 30, 2014
    Applicant: VERSI GROUP, LLC
    Inventors: KWEN-JEN CHANG, KLIM KING, KESTUTIS P. BICIUNAS, ROBERT W. MCNUTT, WILLIAM PENDERGAST, SHY-TAI JAN
  • Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
    Patent number: 8575169
    Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
    Type: Grant
    Filed: January 2, 2003
    Date of Patent: November 5, 2013
    Assignee: Versi Group, LLC
    Inventors: Kwen-Jen Chang, Klim King, Kestutis P. Biciunas, Robert W. McNutt, Jr., William Pendergast, Shyi-Tai Jan
  • Delta opioid receptor agonist compounds
    Patent number: 8551998
    Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: October 8, 2013
    Assignee: Versi Group, LLC
    Inventors: Kwen-Jen Chang, Klim King, Kestutis P. Biciunas, Robert W. McNutt, Jr., William Pendergast, Shy-Tai Jan
  • Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
    Publication number: 20130053326
    Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
    Type: Application
    Filed: January 2, 2003
    Publication date: February 28, 2013
    Inventors: Kwen-Jen Chang, Klim King, Kestutis P. Biciunas, Robert W. McNutt, JR., William Pendergast, Shyi-Tai Jan