Abstract: The present invention concerns an elastomeric stopper (18, 28, 38) for a drug reservoir, comprising: a stopper body (18.1, 28.1, 38.1) extending along a reference axis between a leading end surface (18.2, 28.2, 38.2) and a trailing end surface (18.3, 28.3, 38.3) and having a generally cylindrical sidewall with an outer body diameter, a circumferential convex rib (18.6, 28.6, 38.6) extending radially outwardly from the sidewall, a non-convex trim edge portion (18.7, 28.7, 38.7) at the trailing end surface (18.3, 28.3, 38.3), the non-convex trim edge portion (18.7, 28.7, 38.7) having an outer trim edge diameter which is greater than the outer body diameter and being axially spaced apart from the circumferential convex rib (18.6, 28.6, 38.6), providing an annular recess (18.9, 28.9, 38.9) therebetween. The elastomeric stopper (18, 28, 38) further comprises a channel structure (18.10, 28.10, 38.10) enabling fluid flow from the trailing end surface (18.3, 28.3, 38.3) to the annular recess (18.9, 28.9, 38.

Abstract: The present invention provides a drug reservoir (1) comprising a reservoir body (2) extending between an outlet end (4) and a proximal end (7), a front piston (8) arranged in a pre-use position within the reservoir body (2) between the outlet end (4) and the proximal end (7), a rear piston (9) arranged within the reservoir body (2) between the front piston (8) and the proximal end (7) a distal chamber (10) defined by the outlet end (4), a first portion of the reservoir body (2), and the front piston (8), the distal chamber (10) holding first contents (18), a proximal chamber (11) defined by the front piston (8), a second portion of the reservoir body (2), and the rear piston (9), the proximal chamber (11) holding second contents (12, 19) comprising a proximal liquid volume (19), and bypass means (3) allowing fluid flow past the front piston (8) in an advanced position of the front piston (8) in the reservoir body (2), wherein the second contents (12, 19) further comprises a proximal gas volume (12) lying with

Abstract: The invention provides a drug delivery device adapted to receive a cartridge, the cartridge being adapted to receive a needle assembly. The drug delivery device comprises a front-loaded cartridge holder adapted to receive and hold a cartridge in a mounted state and being actuatable between an open loading state and a closed operational state. The drug delivery device is further provided with blocking means configured to prevent the cartridge holder from being actuated between the closed and the open state when a cartridge with a mounted needle assembly is held in a mounted position.

Abstract: The present invention relates to injection devices for injecting a medicament from a cartridge (600) through a needle cannula (510). The injection device (100) includes an actuator (330, 360) for driving a piston driver (310) and includes an end of stroke limiter (341, 611). When the piston driver (310) is arrested by the end of stroke limiter (341, 611) a shielding driver (370) is automatically triggered to actively shift the needle cannula (510) into a shielded state. The injection device may include a fluid dispensing interruption mechanism that automatically interrupts fluid flow when the piston driver has moved a predetermined stroke length. The injection device may also include a single pre-stressed spring acting exclusively in a linear compression mode or exclusively in a torsion mode and adapted to sequentially drive the device to enable fully automatic operation. The invention also relates to a method of sterilizing a needle cannula assembly.

Abstract: The present invention relates to injection devices for injecting a medicament from a cartridge (600) through a needle cannula (510). The injection device (100) includes an actuator (330, 360) for driving a piston driver (310) and includes an end of stroke limiter (341, 611). When the piston driver (310) is arrested by the end of stroke limiter (341, 611) a shielding driver (370) is automatically triggered to actively shift the needle cannula (510) into a shielded state. The injection device may include a fluid dispensing interruption mechanism that automatically interrupts fluid flow when the piston driver has moved a predetermined stroke length. The injection device may also include a single pre-stressed spring acting exclusively in a linear compression mode or exclusively in a torsion mode and adapted to sequentially drive the device to enable fully automatic operation. The invention also relates to a method of sterilizing a needle cannula assembly.